ZNF76_HUMAN
ID ZNF76_HUMAN Reviewed; 570 AA.
AC P36508; Q9BQB2;
DT 01-JUN-1994, integrated into UniProtKB/Swiss-Prot.
DT 02-MAY-2002, sequence version 2.
DT 03-AUG-2022, entry version 197.
DE RecName: Full=Zinc finger protein 76;
DE AltName: Full=Zinc finger protein 523;
GN Name=ZNF76; Synonyms=D6S229E, ZNF523;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
RX PubMed=1427894; DOI=10.1016/s0888-7543(05)80167-3;
RA Ragoussis J., Senger G., Mockridge I., Sanseau P., Ruddy S., Dudley K.,
RA Sheer D., Trowsdale J.;
RT "A testis-expressed Zn finger gene (ZNF76) in human 6p21.3 centromeric to
RT the MHC is closely linked to the human homolog of the T-complex gene tcp-
RT 11.";
RL Genomics 14:673-679(1992).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RA Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S.,
RA Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y.,
RA Phelan M., Farmer A.;
RT "Cloning of human full-length CDSs in BD Creator(TM) system donor vector.";
RL Submitted (OCT-2004) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC TISSUE=Placenta;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP SUMOYLATION [LARGE SCALE ANALYSIS] AT LYS-24, AND IDENTIFICATION BY MASS
RP SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=28112733; DOI=10.1038/nsmb.3366;
RA Hendriks I.A., Lyon D., Young C., Jensen L.J., Vertegaal A.C.,
RA Nielsen M.L.;
RT "Site-specific mapping of the human SUMO proteome reveals co-modification
RT with phosphorylation.";
RL Nat. Struct. Mol. Biol. 24:325-336(2017).
CC -!- FUNCTION: May be involved in transcriptional regulation.
CC -!- INTERACTION:
CC P36508; Q9BWD1: ACAT2; NbExp=3; IntAct=EBI-7254550, EBI-1047273;
CC P36508; Q9BYJ1: ALOXE3; NbExp=3; IntAct=EBI-7254550, EBI-6925949;
CC P36508; Q7Z713: ANKRD37; NbExp=3; IntAct=EBI-7254550, EBI-12373689;
CC P36508; Q9BQD7: ANTKMT; NbExp=3; IntAct=EBI-7254550, EBI-713602;
CC P36508; P48047: ATP5PO; NbExp=3; IntAct=EBI-7254550, EBI-355815;
CC P36508; Q9H2G9: BLZF1; NbExp=3; IntAct=EBI-7254550, EBI-2548012;
CC P36508; A0A087WZT3: BOLA2B; NbExp=3; IntAct=EBI-7254550, EBI-12006120;
CC P36508; Q5SWW7: C10orf55; NbExp=3; IntAct=EBI-7254550, EBI-12809220;
CC P36508; Q8WYQ4-2: C22orf15; NbExp=3; IntAct=EBI-7254550, EBI-12030460;
CC P36508; Q3SXR2: C3orf36; NbExp=3; IntAct=EBI-7254550, EBI-18036948;
CC P36508; P40199: CEACAM6; NbExp=3; IntAct=EBI-7254550, EBI-4314501;
CC P36508; Q8TAP6: CEP76; NbExp=3; IntAct=EBI-7254550, EBI-742887;
CC P36508; P07498: CSN3; NbExp=3; IntAct=EBI-7254550, EBI-2602175;
CC P36508; Q96D03: DDIT4L; NbExp=3; IntAct=EBI-7254550, EBI-742054;
CC P36508; Q9NRI5-2: DISC1; NbExp=3; IntAct=EBI-7254550, EBI-11988027;
CC P36508; Q9H0I2: ENKD1; NbExp=3; IntAct=EBI-7254550, EBI-744099;
CC P36508; Q9Y3B2: EXOSC1; NbExp=3; IntAct=EBI-7254550, EBI-371892;
CC P36508; Q86W67: FAM228A; NbExp=3; IntAct=EBI-7254550, EBI-12958227;
CC P36508; Q86YD7: FAM90A1; NbExp=3; IntAct=EBI-7254550, EBI-6658203;
CC P36508; Q96PJ5: FCRL4; NbExp=3; IntAct=EBI-7254550, EBI-4314687;
CC P36508; Q14192: FHL2; NbExp=3; IntAct=EBI-7254550, EBI-701903;
CC P36508; Q8TC99: FNDC8; NbExp=3; IntAct=EBI-7254550, EBI-12903902;
CC P36508; A1L4K1: FSD2; NbExp=3; IntAct=EBI-7254550, EBI-5661036;
CC P36508; Q8TC17: GRAPL; NbExp=3; IntAct=EBI-7254550, EBI-18300553;
CC P36508; Q9UKT9: IKZF3; NbExp=3; IntAct=EBI-7254550, EBI-747204;
CC P36508; Q7L273: KCTD9; NbExp=3; IntAct=EBI-7254550, EBI-4397613;
CC P36508; Q9UIH9: KLF15; NbExp=3; IntAct=EBI-7254550, EBI-2796400;
CC P36508; O00505: KPNA3; NbExp=3; IntAct=EBI-7254550, EBI-358297;
CC P36508; Q6A162: KRT40; NbExp=3; IntAct=EBI-7254550, EBI-10171697;
CC P36508; O95678: KRT75; NbExp=3; IntAct=EBI-7254550, EBI-2949715;
CC P36508; Q96JM7-2: L3MBTL3; NbExp=3; IntAct=EBI-7254550, EBI-11985629;
CC P36508; P28838: LAP3; NbExp=3; IntAct=EBI-7254550, EBI-2339312;
CC P36508; O95202: LETM1; NbExp=3; IntAct=EBI-7254550, EBI-1052895;
CC P36508; Q9UBR4-2: LHX3; NbExp=5; IntAct=EBI-7254550, EBI-12039345;
CC P36508; Q969G2: LHX4; NbExp=3; IntAct=EBI-7254550, EBI-2865388;
CC P36508; Q9UPM6: LHX6; NbExp=3; IntAct=EBI-7254550, EBI-10258746;
CC P36508; Q96GY3: LIN37; NbExp=3; IntAct=EBI-7254550, EBI-748884;
CC P36508; Q6MZP7: LIN54; NbExp=3; IntAct=EBI-7254550, EBI-1389411;
CC P36508; P25800: LMO1; NbExp=3; IntAct=EBI-7254550, EBI-8639312;
CC P36508; P43360: MAGEA6; NbExp=3; IntAct=EBI-7254550, EBI-1045155;
CC P36508; Q8WWY6: MBD3L1; NbExp=3; IntAct=EBI-7254550, EBI-12516603;
CC P36508; Q9P267-2: MBD5; NbExp=3; IntAct=EBI-7254550, EBI-17671489;
CC P36508; A0JLT2-2: MED19; NbExp=3; IntAct=EBI-7254550, EBI-13288755;
CC P36508; P55081: MFAP1; NbExp=3; IntAct=EBI-7254550, EBI-1048159;
CC P36508; Q6PF18: MORN3; NbExp=3; IntAct=EBI-7254550, EBI-9675802;
CC P36508; P52815: MRPL12; NbExp=3; IntAct=EBI-7254550, EBI-358272;
CC P36508; Q9H019: MTFR1L; NbExp=3; IntAct=EBI-7254550, EBI-2824497;
CC P36508; Q5JR59-3: MTUS2; NbExp=3; IntAct=EBI-7254550, EBI-11522433;
CC P36508; Q9BUA6: MYL10; NbExp=3; IntAct=EBI-7254550, EBI-17561739;
CC P36508; Q14511-2: NEDD9; NbExp=3; IntAct=EBI-7254550, EBI-11746523;
CC P36508; Q9BQI9: NRIP2; NbExp=3; IntAct=EBI-7254550, EBI-3913975;
CC P36508; Q10713: PMPCA; NbExp=3; IntAct=EBI-7254550, EBI-2514696;
CC P36508; Q7Z3K3: POGZ; NbExp=3; IntAct=EBI-7254550, EBI-1389308;
CC P36508; P31321: PRKAR1B; NbExp=3; IntAct=EBI-7254550, EBI-2805516;
CC P36508; Q96QF0-7: RAB3IP; NbExp=3; IntAct=EBI-7254550, EBI-11984839;
CC P36508; Q53GL6: RALY; NbExp=3; IntAct=EBI-7254550, EBI-9512693;
CC P36508; Q04864-2: REL; NbExp=3; IntAct=EBI-7254550, EBI-10829018;
CC P36508; Q96P16-3: RPRD1A; NbExp=3; IntAct=EBI-7254550, EBI-12840198;
CC P36508; P63220: RPS21; NbExp=3; IntAct=EBI-7254550, EBI-714051;
CC P36508; Q9BWG6: SCNM1; NbExp=3; IntAct=EBI-7254550, EBI-748391;
CC P36508; Q8ND83: SLAIN1; NbExp=3; IntAct=EBI-7254550, EBI-10269374;
CC P36508; O43623: SNAI2; NbExp=3; IntAct=EBI-7254550, EBI-9876238;
CC P36508; Q5MJ09: SPANXN3; NbExp=3; IntAct=EBI-7254550, EBI-12037215;
CC P36508; Q6RVD6: SPATA8; NbExp=3; IntAct=EBI-7254550, EBI-8635958;
CC P36508; Q9NZ72: STMN3; NbExp=3; IntAct=EBI-7254550, EBI-725557;
CC P36508; Q5VWN6: TASOR2; NbExp=3; IntAct=EBI-7254550, EBI-745958;
CC P36508; Q9NU19: TBC1D22B; NbExp=3; IntAct=EBI-7254550, EBI-8787464;
CC P36508; Q96M29: TEKT5; NbExp=3; IntAct=EBI-7254550, EBI-10239812;
CC P36508; Q6ZNM6: TEX43; NbExp=3; IntAct=EBI-7254550, EBI-18115728;
CC P36508; Q96RS0: TGS1; NbExp=3; IntAct=EBI-7254550, EBI-949244;
CC P36508; P19237: TNNI1; NbExp=3; IntAct=EBI-7254550, EBI-746692;
CC P36508; Q70EL1-9: USP54; NbExp=3; IntAct=EBI-7254550, EBI-11975223;
CC P36508; Q93009: USP7; NbExp=3; IntAct=EBI-7254550, EBI-302474;
CC P36508; Q8TAG6: VXN; NbExp=3; IntAct=EBI-7254550, EBI-12071548;
CC P36508; Q9BRX9: WDR83; NbExp=3; IntAct=EBI-7254550, EBI-7705033;
CC P36508; Q53FD0-2: ZC2HC1C; NbExp=3; IntAct=EBI-7254550, EBI-14104088;
CC P36508; Q9NQZ6: ZC4H2; NbExp=5; IntAct=EBI-7254550, EBI-747993;
CC P36508; O95789-4: ZMYM6; NbExp=3; IntAct=EBI-7254550, EBI-12949277;
CC P36508; Q8TAQ5: ZNF420; NbExp=3; IntAct=EBI-7254550, EBI-3923307;
CC P36508; Q8TF50: ZNF526; NbExp=3; IntAct=EBI-7254550, EBI-11035148;
CC P36508; O75123: ZNF623; NbExp=3; IntAct=EBI-7254550, EBI-18560922;
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=2;
CC IsoId=P36508-1; Sequence=Displayed;
CC Name=1;
CC IsoId=P36508-2; Sequence=VSP_006894;
CC -!- TISSUE SPECIFICITY: Testis.
CC -!- SIMILARITY: Belongs to the krueppel C2H2-type zinc-finger protein
CC family. {ECO:0000305}.
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DR EMBL; M91592; AAA98739.1; -; mRNA.
DR EMBL; BT007316; AAP35980.1; -; mRNA.
DR EMBL; BC000133; AAH00133.1; -; mRNA.
DR EMBL; BC002549; AAH02549.1; -; mRNA.
DR CCDS; CCDS4801.1; -. [P36508-1]
DR CCDS; CCDS75435.1; -. [P36508-2]
DR PIR; A44256; A44256.
DR RefSeq; NP_001278961.1; NM_001292032.1. [P36508-2]
DR RefSeq; NP_003418.2; NM_003427.4. [P36508-1]
DR RefSeq; XP_016866738.1; XM_017011249.1. [P36508-1]
DR AlphaFoldDB; P36508; -.
DR SMR; P36508; -.
DR BioGRID; 113448; 103.
DR IntAct; P36508; 85.
DR MINT; P36508; -.
DR STRING; 9606.ENSP00000363064; -.
DR iPTMnet; P36508; -.
DR PhosphoSitePlus; P36508; -.
DR BioMuta; ZNF76; -.
DR DMDM; 20455531; -.
DR EPD; P36508; -.
DR jPOST; P36508; -.
DR MassIVE; P36508; -.
DR MaxQB; P36508; -.
DR PaxDb; P36508; -.
DR PeptideAtlas; P36508; -.
DR PRIDE; P36508; -.
DR ProteomicsDB; 55204; -. [P36508-1]
DR ProteomicsDB; 55205; -. [P36508-2]
DR Antibodypedia; 15181; 133 antibodies from 26 providers.
DR DNASU; 7629; -.
DR Ensembl; ENST00000339411.5; ENSP00000344097.5; ENSG00000065029.15. [P36508-2]
DR Ensembl; ENST00000373953.8; ENSP00000363064.3; ENSG00000065029.15. [P36508-1]
DR GeneID; 7629; -.
DR KEGG; hsa:7629; -.
DR MANE-Select; ENST00000373953.8; ENSP00000363064.3; NM_003427.5; NP_003418.2.
DR UCSC; uc003oki.2; human. [P36508-1]
DR CTD; 7629; -.
DR DisGeNET; 7629; -.
DR GeneCards; ZNF76; -.
DR HGNC; HGNC:13149; ZNF76.
DR HPA; ENSG00000065029; Low tissue specificity.
DR MIM; 194549; gene.
DR neXtProt; NX_P36508; -.
DR OpenTargets; ENSG00000065029; -.
DR PharmGKB; PA37723; -.
DR VEuPathDB; HostDB:ENSG00000065029; -.
DR eggNOG; KOG1721; Eukaryota.
DR GeneTree; ENSGT00940000160911; -.
DR HOGENOM; CLU_027168_0_0_1; -.
DR InParanoid; P36508; -.
DR OMA; AAIQHEP; -.
DR OrthoDB; 1318335at2759; -.
DR PhylomeDB; P36508; -.
DR TreeFam; TF333498; -.
DR PathwayCommons; P36508; -.
DR SignaLink; P36508; -.
DR SIGNOR; P36508; -.
DR BioGRID-ORCS; 7629; 14 hits in 1100 CRISPR screens.
DR ChiTaRS; ZNF76; human.
DR GeneWiki; ZNF76; -.
DR GenomeRNAi; 7629; -.
DR Pharos; P36508; Tbio.
DR PRO; PR:P36508; -.
DR Proteomes; UP000005640; Chromosome 6.
DR RNAct; P36508; protein.
DR Bgee; ENSG00000065029; Expressed in right lobe of thyroid gland and 173 other tissues.
DR ExpressionAtlas; P36508; baseline and differential.
DR Genevisible; P36508; HS.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0001228; F:DNA-binding transcription activator activity, RNA polymerase II-specific; IDA:NTNU_SB.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0043565; F:sequence-specific DNA binding; IDA:NTNU_SB.
DR GO; GO:1990837; F:sequence-specific double-stranded DNA binding; IDA:ARUK-UCL.
DR GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IDA:NTNU_SB.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR GO; GO:0006359; P:regulation of transcription by RNA polymerase III; TAS:ProtInc.
DR InterPro; IPR036236; Znf_C2H2_sf.
DR InterPro; IPR013087; Znf_C2H2_type.
DR Pfam; PF00096; zf-C2H2; 4.
DR SMART; SM00355; ZnF_C2H2; 7.
DR SUPFAM; SSF57667; SSF57667; 4.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 7.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 7.
PE 1: Evidence at protein level;
KW Alternative splicing; DNA-binding; Isopeptide bond; Metal-binding; Nucleus;
KW Reference proteome; Repeat; Transcription; Transcription regulation;
KW Ubl conjugation; Zinc; Zinc-finger.
FT CHAIN 1..570
FT /note="Zinc finger protein 76"
FT /id="PRO_0000047386"
FT REPEAT 34..45
FT /note="1"
FT REPEAT 62..73
FT /note="2"
FT REPEAT 88..99
FT /note="3"
FT ZN_FING 165..189
FT /note="C2H2-type 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 195..219
FT /note="C2H2-type 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 225..249
FT /note="C2H2-type 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 255..279
FT /note="C2H2-type 4"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 285..309
FT /note="C2H2-type 5"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 315..339
FT /note="C2H2-type 6"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 345..368
FT /note="C2H2-type 7"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT REGION 34..99
FT /note="3 X 12 AA approximate repeats"
FT REGION 365..401
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CROSSLNK 24
FT /note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
FT G-Cter in SUMO2)"
FT /evidence="ECO:0007744|PubMed:28112733"
FT VAR_SEQ 444..498
FT /note="Missing (in isoform 1)"
FT /evidence="ECO:0000303|PubMed:1427894"
FT /id="VSP_006894"
FT VARIANT 48
FT /note="T -> M (in dbSNP:rs2228265)"
FT /id="VAR_033546"
FT VARIANT 272
FT /note="R -> C (in dbSNP:rs33959228)"
FT /id="VAR_033547"
FT VARIANT 403
FT /note="R -> Q (in dbSNP:rs35582935)"
FT /id="VAR_033548"
FT CONFLICT 334..335
FT /note="KH -> ND (in Ref. 1; AAA98739)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 570 AA; 61831 MW; 333C99E0E79D86C2 CRC64;
MESLGLHTVT LSDGTTAYVQ QAVKGEKLLE GQVIQLEDGT TAYIHQVTVQ KEALSFEDGQ
PVQLEDGSMA YIHRTPREGY DPSTLEAVQL EDGSTAYIHH PVAVPSESTI LAVQTEVGLE
DLAAEDDEGF SADAVVALEQ YASKVLHDSQ IPRNGKGQQV GDRAFRCGYK GCGRLYTTAH
HLKVHERAHT GDRPYRCDFP SCGKAFATGY GLKSHVRTHT GEKPYKCPEE LCSKAFKTSG
DLQKHVRTHT GERPFQCPFE GCGRSFTTSN IRKVHVRTHT GERPYTCPEP HCGRGFTSAT
NYKNHVRIHT GEKPYVCTVP GCGKRFTEYS SLYKHHVVHT HCKPYTCSTC GKTYRQTSTL
AMHKRSAHGE LEATEESEQA LYEQQQLEAA SAAEESPPPK RPRIAYLSEV KEERDDIPAQ
VAMVTEEDGA PQVALITQDG AQQVSLSPED LQALGSAISM VTQHGSTTLT IPSPDADLAT
SGTHTVTMVS ADGTQTQPVT IITSGAVVAE DSSVASLRHQ QVALLATANG THIAVQLEEQ
QTLEEAINVA TAAMQQGAVT LETTVSESGC
