ZNF76_MOUSE
ID ZNF76_MOUSE Reviewed; 568 AA.
AC Q8BMU0; Q6P9T2;
DT 04-NOV-2008, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2003, sequence version 1.
DT 03-AUG-2022, entry version 162.
DE RecName: Full=Zinc finger protein 76;
DE AltName: Full=Zinc finger protein 523;
GN Name=Znf76; Synonyms=Zfp523;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC STRAIN=C57BL/6J;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
RC STRAIN=C57BL/6J; TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: May be involved in transcriptional regulation.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q8BMU0-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q8BMU0-2; Sequence=VSP_035628, VSP_035629;
CC -!- SIMILARITY: Belongs to the krueppel C2H2-type zinc-finger protein
CC family. {ECO:0000305}.
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DR EMBL; AK028222; BAC25822.1; -; mRNA.
DR EMBL; CT009658; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC058346; AAH58346.1; -; mRNA.
DR EMBL; BC060611; AAH60611.1; -; mRNA.
DR CCDS; CCDS28573.1; -. [Q8BMU0-1]
DR RefSeq; NP_766205.1; NM_172617.3. [Q8BMU0-1]
DR RefSeq; XP_006524155.1; XM_006524092.3.
DR RefSeq; XP_017172898.1; XM_017317409.1. [Q8BMU0-1]
DR AlphaFoldDB; Q8BMU0; -.
DR SMR; Q8BMU0; -.
DR BioGRID; 230298; 1.
DR STRING; 10090.ENSMUSP00000002318; -.
DR iPTMnet; Q8BMU0; -.
DR PhosphoSitePlus; Q8BMU0; -.
DR MaxQB; Q8BMU0; -.
DR PaxDb; Q8BMU0; -.
DR PeptideAtlas; Q8BMU0; -.
DR PRIDE; Q8BMU0; -.
DR ProteomicsDB; 275098; -. [Q8BMU0-1]
DR ProteomicsDB; 275099; -. [Q8BMU0-2]
DR Antibodypedia; 15181; 133 antibodies from 26 providers.
DR DNASU; 224656; -.
DR Ensembl; ENSMUST00000002318; ENSMUSP00000002318; ENSMUSG00000024220. [Q8BMU0-1]
DR Ensembl; ENSMUST00000073534; ENSMUSP00000073226; ENSMUSG00000024220. [Q8BMU0-1]
DR Ensembl; ENSMUST00000233613; ENSMUSP00000156638; ENSMUSG00000024220. [Q8BMU0-1]
DR GeneID; 224656; -.
DR KEGG; mmu:224656; -.
DR UCSC; uc008bqg.2; mouse. [Q8BMU0-1]
DR CTD; 224656; -.
DR MGI; MGI:2687278; Zfp523.
DR VEuPathDB; HostDB:ENSMUSG00000024220; -.
DR eggNOG; KOG1721; Eukaryota.
DR GeneTree; ENSGT00940000160911; -.
DR HOGENOM; CLU_027168_0_0_1; -.
DR InParanoid; Q8BMU0; -.
DR OMA; AAIQHEP; -.
DR OrthoDB; 1318335at2759; -.
DR PhylomeDB; Q8BMU0; -.
DR TreeFam; TF333498; -.
DR BioGRID-ORCS; 224656; 3 hits in 73 CRISPR screens.
DR ChiTaRS; Zfp523; mouse.
DR PRO; PR:Q8BMU0; -.
DR Proteomes; UP000000589; Chromosome 17.
DR RNAct; Q8BMU0; protein.
DR Bgee; ENSMUSG00000024220; Expressed in interventricular septum and 225 other tissues.
DR ExpressionAtlas; Q8BMU0; baseline and differential.
DR Genevisible; Q8BMU0; MM.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0001228; F:DNA-binding transcription activator activity, RNA polymerase II-specific; ISO:MGI.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0043565; F:sequence-specific DNA binding; ISO:MGI.
DR GO; GO:1990837; F:sequence-specific double-stranded DNA binding; ISO:MGI.
DR GO; GO:0007417; P:central nervous system development; IBA:GO_Central.
DR GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; ISO:MGI.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR InterPro; IPR036236; Znf_C2H2_sf.
DR InterPro; IPR013087; Znf_C2H2_type.
DR Pfam; PF00096; zf-C2H2; 4.
DR SMART; SM00355; ZnF_C2H2; 7.
DR SUPFAM; SSF57667; SSF57667; 4.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 7.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 7.
PE 2: Evidence at transcript level;
KW Alternative splicing; DNA-binding; Isopeptide bond; Metal-binding; Nucleus;
KW Reference proteome; Repeat; Transcription; Transcription regulation;
KW Ubl conjugation; Zinc; Zinc-finger.
FT CHAIN 1..568
FT /note="Zinc finger protein 76"
FT /id="PRO_0000353096"
FT REPEAT 34..45
FT /note="1"
FT REPEAT 62..73
FT /note="2"
FT REPEAT 88..99
FT /note="3"
FT ZN_FING 165..189
FT /note="C2H2-type 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 195..219
FT /note="C2H2-type 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 225..249
FT /note="C2H2-type 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 255..279
FT /note="C2H2-type 4"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 285..309
FT /note="C2H2-type 5"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 315..339
FT /note="C2H2-type 6"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 345..368
FT /note="C2H2-type 7"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT REGION 34..99
FT /note="3 X 12 AA approximate repeats"
FT REGION 365..402
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CROSSLNK 24
FT /note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
FT G-Cter in SUMO2)"
FT /evidence="ECO:0000250|UniProtKB:P36508"
FT VAR_SEQ 312..316
FT /note="EKPYV -> GPAGV (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_035628"
FT VAR_SEQ 317..568
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_035629"
SQ SEQUENCE 568 AA; 61454 MW; 1A3A1684C766CA7F CRC64;
MESLGLQTVR LSDGTTAYVQ QAVKGEKLLE GQVIQLEDGT TAYIHQVTIQ KESFSFEDGQ
PVQLEDGSMA YIHHTPKEGC DPSALEAVQL EDGSTAYIHH PVPVPSDSAI LAVQTEAGLE
DLAAEDEEGF GTDTVVALEQ YASKVLHDSP ASHNGKGQQV GDRAFRCGYK GCGRLYTTAH
HLKVHERAHT GDRPYRCDFP SCGKAFATGY GLKSHVRTHT GEKPYKCPEE LCSKAFKTSG
DLQKHVRTHT GERPFRCPFE GCGRSFTTSN IRKVHVRTHT GERPYTCPEP HCGRGFTSAT
NYKNHVRIHT GEKPYVCTVP GCGKRFTEYS SLYKHHVVHT HCKPYTCSSC GKTYRQTSTL
AMHKRSAHGE LEATEESEQA LYEQQQLEAA SAAEESPPPK PTHIAYLSEV KEESSAIPTQ
VAMVTEEDGP PQVALITQDG TQQVSLSPED LQALGSAISV VTQHGSTTLT IPGHHEELAT
SGTHTVTMVS ADGTQTQPVT IITSGALVTE DSSVASLHHQ QVALLATANG THIAVQLEDQ
QTLEEAISVA TAAMQQGAVT LETTESGC
