ZNF77_HUMAN
ID ZNF77_HUMAN Reviewed; 545 AA.
AC Q15935; Q86XJ3; Q9NPP0;
DT 08-NOV-2002, integrated into UniProtKB/Swiss-Prot.
DT 10-JAN-2006, sequence version 2.
DT 03-AUG-2022, entry version 179.
DE RecName: Full=Zinc finger protein 77;
DE AltName: Full=ZNFpT1;
GN Name=ZNF77;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Ovary, and Testis;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 93-321.
RX PubMed=8478004; DOI=10.1007/bf00218259;
RA Huebner K., Druck T., LaForgia S., Lasota J., Croce C.M., Lanfrancone L.,
RA Donti E., Pengue G., la Mantia G., Pelicci P.-G., Lania L.;
RT "Chromosomal localization of four human zinc finger cDNAs.";
RL Hum. Genet. 91:217-222(1993).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 270-545.
RG The European IMAGE consortium;
RL Submitted (JUL-2000) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: May be involved in transcriptional regulation.
CC -!- INTERACTION:
CC Q15935; Q9C0B1-2: FTO; NbExp=3; IntAct=EBI-12840750, EBI-18138793;
CC Q15935; Q8WWY6: MBD3L1; NbExp=3; IntAct=EBI-12840750, EBI-12516603;
CC Q15935; Q8N6F8: METTL27; NbExp=3; IntAct=EBI-12840750, EBI-8487781;
CC Q15935; Q9BSH3: NICN1; NbExp=3; IntAct=EBI-12840750, EBI-13324229;
CC Q15935; P30048: PRDX3; NbExp=3; IntAct=EBI-12840750, EBI-748336;
CC Q15935; Q2I0M5: RSPO4; NbExp=3; IntAct=EBI-12840750, EBI-12821217;
CC Q15935; Q9BVN2: RUSC1; NbExp=3; IntAct=EBI-12840750, EBI-6257312;
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the krueppel C2H2-type zinc-finger protein
CC family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=CAA46337.1; Type=Frameshift; Evidence={ECO:0000305};
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DR EMBL; BC043354; AAH43354.2; -; mRNA.
DR EMBL; BC062561; AAH62561.1; -; mRNA.
DR EMBL; X65230; CAA46337.1; ALT_FRAME; mRNA.
DR EMBL; AL365370; CAB96946.1; -; mRNA.
DR CCDS; CCDS12099.1; -.
DR PIR; I39313; I39313.
DR RefSeq; NP_067040.1; NM_021217.2.
DR AlphaFoldDB; Q15935; -.
DR SMR; Q15935; -.
DR BioGRID; 121822; 19.
DR IntAct; Q15935; 9.
DR STRING; 9606.ENSP00000319053; -.
DR iPTMnet; Q15935; -.
DR PhosphoSitePlus; Q15935; -.
DR BioMuta; ZNF77; -.
DR DMDM; 85681869; -.
DR jPOST; Q15935; -.
DR MassIVE; Q15935; -.
DR MaxQB; Q15935; -.
DR PaxDb; Q15935; -.
DR PeptideAtlas; Q15935; -.
DR PRIDE; Q15935; -.
DR ProteomicsDB; 60820; -.
DR Antibodypedia; 10862; 65 antibodies from 16 providers.
DR DNASU; 58492; -.
DR Ensembl; ENST00000314531.5; ENSP00000319053.3; ENSG00000175691.9.
DR GeneID; 58492; -.
DR KEGG; hsa:58492; -.
DR MANE-Select; ENST00000314531.5; ENSP00000319053.3; NM_021217.3; NP_067040.1.
DR UCSC; uc002lws.5; human.
DR CTD; 58492; -.
DR DisGeNET; 58492; -.
DR GeneCards; ZNF77; -.
DR HGNC; HGNC:13150; ZNF77.
DR HPA; ENSG00000175691; Low tissue specificity.
DR MIM; 194551; gene.
DR neXtProt; NX_Q15935; -.
DR OpenTargets; ENSG00000175691; -.
DR PharmGKB; PA37724; -.
DR VEuPathDB; HostDB:ENSG00000175691; -.
DR eggNOG; KOG1721; Eukaryota.
DR GeneTree; ENSGT00940000162830; -.
DR HOGENOM; CLU_002678_0_10_1; -.
DR InParanoid; Q15935; -.
DR OMA; QQCEKAY; -.
DR OrthoDB; 1318335at2759; -.
DR PhylomeDB; Q15935; -.
DR TreeFam; TF338854; -.
DR PathwayCommons; Q15935; -.
DR Reactome; R-HSA-212436; Generic Transcription Pathway.
DR SignaLink; Q15935; -.
DR BioGRID-ORCS; 58492; 9 hits in 1099 CRISPR screens.
DR ChiTaRS; ZNF77; human.
DR GenomeRNAi; 58492; -.
DR Pharos; Q15935; Tbio.
DR PRO; PR:Q15935; -.
DR Proteomes; UP000005640; Chromosome 19.
DR RNAct; Q15935; protein.
DR Bgee; ENSG00000175691; Expressed in oocyte and 121 other tissues.
DR Genevisible; Q15935; HS.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0001227; F:DNA-binding transcription repressor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0000977; F:RNA polymerase II transcription regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR CDD; cd07765; KRAB_A-box; 1.
DR InterPro; IPR001909; KRAB.
DR InterPro; IPR036051; KRAB_dom_sf.
DR InterPro; IPR036236; Znf_C2H2_sf.
DR InterPro; IPR013087; Znf_C2H2_type.
DR Pfam; PF01352; KRAB; 1.
DR Pfam; PF00096; zf-C2H2; 6.
DR SMART; SM00349; KRAB; 1.
DR SMART; SM00355; ZnF_C2H2; 12.
DR SUPFAM; SSF109640; SSF109640; 1.
DR SUPFAM; SSF57667; SSF57667; 8.
DR PROSITE; PS50805; KRAB; 1.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 12.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 12.
PE 1: Evidence at protein level;
KW DNA-binding; Metal-binding; Nucleus; Reference proteome; Repeat;
KW Transcription; Transcription regulation; Zinc; Zinc-finger.
FT CHAIN 1..545
FT /note="Zinc finger protein 77"
FT /id="PRO_0000047387"
FT DOMAIN 4..99
FT /note="KRAB"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00119"
FT ZN_FING 212..234
FT /note="C2H2-type 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 240..262
FT /note="C2H2-type 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 268..290
FT /note="C2H2-type 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 296..318
FT /note="C2H2-type 4"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 324..346
FT /note="C2H2-type 5"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 352..374
FT /note="C2H2-type 6"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 380..402
FT /note="C2H2-type 7"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 408..430
FT /note="C2H2-type 8"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 436..458
FT /note="C2H2-type 9"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 464..486
FT /note="C2H2-type 10"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 492..514
FT /note="C2H2-type 11"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 520..542
FT /note="C2H2-type 12"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT VARIANT 3
FT /note="C -> S (in dbSNP:rs12610412)"
FT /id="VAR_052764"
FT VARIANT 5
FT /note="I -> V (in dbSNP:rs12609268)"
FT /id="VAR_059895"
FT VARIANT 20
FT /note="L -> W (in dbSNP:rs34603238)"
FT /id="VAR_033549"
FT VARIANT 179
FT /note="P -> S (in dbSNP:rs34705382)"
FT /id="VAR_033550"
FT VARIANT 460
FT /note="G -> R (in dbSNP:rs35411355)"
FT /id="VAR_033551"
FT CONFLICT 201
FT /note="T -> R (in Ref. 2; CAA46337)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 545 AA; 61964 MW; 06AF93C62DA8A821 CRC64;
MDCVIFEEVA VNFTPEEWAL LDHAQRSLYR DVMLETCRNL ASLDCYIYVR TSGSSSQRDV
FGNGISNDEE IVKFTGSDSW SIFGENWRFD NTGDQHQIPQ RHLRSQLGRL CESNEGHQCG
ETLSQTANLL VHKSYPTEAK PSECTKCGKA FENRQRSHTG QRPCKECGQA CSCLSCQSPP
MKTQTVEKPC NCQDSRTASV TYVKSLSSKK SYECQKCGKA FICPSSFRGH VNSHHGQKTH
ACKVCGKTFM YYSYLTRHVR THTGEKPYEC KECGKAFSCP SYFREHVRTH TGEKPYECKH
CGKSFSCYSS FRDHVRTHTG EKPCQCKHCG KAFTCYSSLR EHGRTHSGEK PYECKECGKA
FRYPSSLRAH MRMHTGEKPY VCKQCGKAFG CPTYFRRHVK THSGVKPYQC KECGKAYSFS
SSLRIHVRTH TGEKPFECKH CGKAFSCHSS LREHVRTHSG EKPYECNQCG KAFSHAQYFQ
KHVRSHSGVK PYECTECGKA YSCSSSLRVH VRTHTGERPY ECKQCGKTFR YLASLQAHVR
THAGA
