ZNF79_HUMAN
ID ZNF79_HUMAN Reviewed; 498 AA.
AC Q15937; Q5VVW1; Q96NV1;
DT 18-OCT-2001, integrated into UniProtKB/Swiss-Prot.
DT 10-JAN-2006, sequence version 2.
DT 03-AUG-2022, entry version 196.
DE RecName: Full=Zinc finger protein 79;
DE AltName: Full=ZNFpT7;
GN Name=ZNF79;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANTS ILE-31 AND GLY-51.
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15164053; DOI=10.1038/nature02465;
RA Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L.,
RA Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R.,
RA Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S.,
RA Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K.,
RA Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y.,
RA Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C.,
RA Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E.,
RA Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M.,
RA Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J.,
RA Frankish A., Frankland J.A., French L., Fricker D.G., Garner P.,
RA Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S.,
RA Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E.,
RA Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D.,
RA Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E.,
RA Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K.,
RA Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S.,
RA Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J.,
RA Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E.,
RA McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V.,
RA Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S.,
RA Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K.,
RA Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J.,
RA Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M.,
RA West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L.,
RA Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M.,
RA Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J.,
RA Dunham I.;
RT "DNA sequence and analysis of human chromosome 9.";
RL Nature 429:369-374(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANTS ILE-31 AND GLY-51.
RC TISSUE=Lung;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 345-454.
RX PubMed=8478004; DOI=10.1007/bf00218259;
RA Huebner K., Druck T., LaForgia S., Lasota J., Croce C.M., Lanfrancone L.,
RA Donti E., Pengue G., la Mantia G., Pelicci P.-G., Lania L.;
RT "Chromosomal localization of four human zinc finger cDNAs.";
RL Hum. Genet. 91:217-222(1993).
CC -!- FUNCTION: May be involved in transcriptional regulation.
CC -!- INTERACTION:
CC Q15937; P61328-2: FGF12; NbExp=3; IntAct=EBI-10237274, EBI-10699759;
CC Q15937; O76011: KRT34; NbExp=3; IntAct=EBI-10237274, EBI-1047093;
CC Q15937; P60410: KRTAP10-8; NbExp=3; IntAct=EBI-10237274, EBI-10171774;
CC Q15937; Q99750: MDFI; NbExp=3; IntAct=EBI-10237274, EBI-724076;
CC Q15937; P14373: TRIM27; NbExp=3; IntAct=EBI-10237274, EBI-719493;
CC Q15937; P13994: YJU2B; NbExp=3; IntAct=EBI-10237274, EBI-716093;
CC Q15937; O43167: ZBTB24; NbExp=3; IntAct=EBI-10237274, EBI-744471;
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the krueppel C2H2-type zinc-finger protein
CC family. {ECO:0000305}.
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DR EMBL; AK054606; BAB70771.1; -; mRNA.
DR EMBL; AL445222; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC062309; AAH62309.1; -; mRNA.
DR EMBL; X65232; CAA46339.1; -; mRNA.
DR CCDS; CCDS6871.1; -.
DR PIR; I39315; I39315.
DR RefSeq; NP_009066.2; NM_007135.2.
DR AlphaFoldDB; Q15937; -.
DR SMR; Q15937; -.
DR BioGRID; 113451; 13.
DR IntAct; Q15937; 7.
DR STRING; 9606.ENSP00000362446; -.
DR iPTMnet; Q15937; -.
DR PhosphoSitePlus; Q15937; -.
DR BioMuta; ZNF79; -.
DR DMDM; 85681870; -.
DR jPOST; Q15937; -.
DR MassIVE; Q15937; -.
DR MaxQB; Q15937; -.
DR PaxDb; Q15937; -.
DR PeptideAtlas; Q15937; -.
DR PRIDE; Q15937; -.
DR ProteomicsDB; 60821; -.
DR Antibodypedia; 16668; 154 antibodies from 19 providers.
DR DNASU; 7633; -.
DR Ensembl; ENST00000342483.5; ENSP00000362446.4; ENSG00000196152.10.
DR GeneID; 7633; -.
DR KEGG; hsa:7633; -.
DR MANE-Select; ENST00000342483.5; ENSP00000362446.4; NM_007135.3; NP_009066.2.
DR UCSC; uc004bqw.5; human.
DR CTD; 7633; -.
DR GeneCards; ZNF79; -.
DR HGNC; HGNC:13153; ZNF79.
DR HPA; ENSG00000196152; Low tissue specificity.
DR MIM; 194552; gene.
DR neXtProt; NX_Q15937; -.
DR OpenTargets; ENSG00000196152; -.
DR PharmGKB; PA37727; -.
DR VEuPathDB; HostDB:ENSG00000196152; -.
DR eggNOG; KOG1721; Eukaryota.
DR GeneTree; ENSGT00940000163270; -.
DR HOGENOM; CLU_002678_44_17_1; -.
DR InParanoid; Q15937; -.
DR OMA; CETHTKS; -.
DR OrthoDB; 1318335at2759; -.
DR PhylomeDB; Q15937; -.
DR TreeFam; TF337055; -.
DR PathwayCommons; Q15937; -.
DR Reactome; R-HSA-212436; Generic Transcription Pathway.
DR SignaLink; Q15937; -.
DR BioGRID-ORCS; 7633; 9 hits in 1100 CRISPR screens.
DR ChiTaRS; ZNF79; human.
DR GeneWiki; ZNF79; -.
DR GenomeRNAi; 7633; -.
DR Pharos; Q15937; Tbio.
DR PRO; PR:Q15937; -.
DR Proteomes; UP000005640; Chromosome 9.
DR RNAct; Q15937; protein.
DR Bgee; ENSG00000196152; Expressed in tendon of biceps brachii and 145 other tissues.
DR ExpressionAtlas; Q15937; baseline and differential.
DR Genevisible; Q15937; HS.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0001227; F:DNA-binding transcription repressor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0000977; F:RNA polymerase II transcription regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR CDD; cd07765; KRAB_A-box; 1.
DR InterPro; IPR001909; KRAB.
DR InterPro; IPR036051; KRAB_dom_sf.
DR InterPro; IPR036236; Znf_C2H2_sf.
DR InterPro; IPR013087; Znf_C2H2_type.
DR Pfam; PF00096; zf-C2H2; 11.
DR SMART; SM00349; KRAB; 1.
DR SMART; SM00355; ZnF_C2H2; 11.
DR SUPFAM; SSF109640; SSF109640; 1.
DR SUPFAM; SSF57667; SSF57667; 7.
DR PROSITE; PS50805; KRAB; 1.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 11.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 11.
PE 1: Evidence at protein level;
KW DNA-binding; Metal-binding; Nucleus; Reference proteome; Repeat;
KW Transcription; Transcription regulation; Zinc; Zinc-finger.
FT CHAIN 1..498
FT /note="Zinc finger protein 79"
FT /id="PRO_0000047388"
FT DOMAIN 38..109
FT /note="KRAB"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00119"
FT ZN_FING 193..215
FT /note="C2H2-type 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 221..243
FT /note="C2H2-type 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 249..271
FT /note="C2H2-type 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 277..299
FT /note="C2H2-type 4"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 305..327
FT /note="C2H2-type 5"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 333..355
FT /note="C2H2-type 6"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 361..383
FT /note="C2H2-type 7"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 389..411
FT /note="C2H2-type 8"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 417..439
FT /note="C2H2-type 9"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 445..467
FT /note="C2H2-type 10"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 473..495
FT /note="C2H2-type 11"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT REGION 1..23
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VARIANT 31
FT /note="T -> I (in dbSNP:rs13292096)"
FT /evidence="ECO:0000269|PubMed:14702039,
FT ECO:0000269|PubMed:15489334"
FT /id="VAR_024841"
FT VARIANT 51
FT /note="R -> G (in dbSNP:rs4504745)"
FT /evidence="ECO:0000269|PubMed:14702039,
FT ECO:0000269|PubMed:15489334"
FT /id="VAR_024842"
FT VARIANT 401
FT /note="S -> N (in dbSNP:rs3210752)"
FT /id="VAR_059896"
FT CONFLICT 345
FT /note="C -> G (in Ref. 4; CAA46339)"
FT /evidence="ECO:0000305"
FT CONFLICT 375..377
FT /note="Missing (in Ref. 4; CAA46339)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 498 AA; 55350 MW; 6E4A9F5AE680BF0C CRC64;
MLEEGVLPSP GPALPQEENT GEEGMAAGLL TAGPRGSTFF SSVTVAFAQE RWRCLVSTPR
DRFKEGIPGK SRSLVLLGLP VSQPGMNSQL EQREGAWMLE GEDLRSPSPG WKIISGSPPE
QALSEASFQD PCVEMPPGDS DHGTSDLEKS FNLRPVLSPQ QRVPVEARPR KCETHTESFK
NSEILKPHRA KPYACNECGK AFSYCSSLSQ HQKSHTGEKP YECSECGKAF SQSSSLIQHQ
RIHTGEKPYK CSECGRAFSQ NANLTKHQRT HTGEKPYRCS ECEKAFSDCS ALVQHQRIHT
GEKPYECSDC GKAFRHSANL TNHQRTHTGE KPYKCSECGK AFSYCAAFIQ HQRIHTGEKP
YRCAACGKAF SQSANLTNHQ RTHTGEKPYK CSECGKAFSQ STNLIIHQKT HTGEKPYKCN
ECGKFFSESS ALIRHHIIHT GEKPYECNEC GKAFNQSSSL SQHQRIHTGV KPYECSECGK
AFRCSSAFVR HQRLHAGE
