ZNF80_HUMAN
ID ZNF80_HUMAN Reviewed; 273 AA.
AC P51504; Q6NSW4; Q6NT14;
DT 01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
DT 23-SEP-2008, sequence version 2.
DT 03-AUG-2022, entry version 179.
DE RecName: Full=Zinc finger protein 80;
DE AltName: Full=ZNFpT17;
GN Name=ZNF80;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=8478004; DOI=10.1007/bf00218259;
RA Huebner K., Druck T., LaForgia S., Lasota J., Croce C.M., Lanfrancone L.,
RA Donti E., Pengue G., la Mantia G., Pelicci P.-G., Lania L.;
RT "Chromosomal localization of four human zinc finger cDNAs.";
RL Hum. Genet. 91:217-222(1993).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=7659503; DOI=10.1093/nar/23.15.2823;
RA di Cristofano A., Strazzullo M., Longo L., la Mantia G.;
RT "Characterization and genomic mapping of the ZNF80 locus: expression of
RT this zinc-finger gene is driven by a solitary LTR of ERV9 endogenous
RT retroviral family.";
RL Nucleic Acids Res. 23:2823-2830(1995).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: May be involved in transcriptional regulation.
CC -!- INTERACTION:
CC P51504; Q13137: CALCOCO2; NbExp=3; IntAct=EBI-12013828, EBI-739580;
CC P51504; Q9BWT7: CARD10; NbExp=3; IntAct=EBI-12013828, EBI-3866279;
CC P51504; Q86X02: CDR2L; NbExp=3; IntAct=EBI-12013828, EBI-11063830;
CC P51504; A6NEM1: GOLGA6L9; NbExp=3; IntAct=EBI-12013828, EBI-5916454;
CC P51504; Q9UJC3: HOOK1; NbExp=3; IntAct=EBI-12013828, EBI-746704;
CC P51504; Q7Z3Y8: KRT27; NbExp=3; IntAct=EBI-12013828, EBI-3044087;
CC P51504; P60411: KRTAP10-9; NbExp=3; IntAct=EBI-12013828, EBI-10172052;
CC P51504; P60328: KRTAP12-3; NbExp=3; IntAct=EBI-12013828, EBI-11953334;
CC P51504; Q2NL98: VMAC; NbExp=3; IntAct=EBI-12013828, EBI-2803134;
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the krueppel C2H2-type zinc-finger protein
CC family. {ECO:0000305}.
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DR EMBL; X65233; CAA46340.1; -; mRNA.
DR EMBL; CH471052; EAW79603.1; -; Genomic_DNA.
DR EMBL; BC069606; AAH69606.2; -; mRNA.
DR EMBL; BC069826; AAH69826.2; -; mRNA.
DR EMBL; BC129925; AAI29926.1; -; mRNA.
DR CCDS; CCDS2979.1; -.
DR RefSeq; NP_009067.2; NM_007136.3.
DR RefSeq; XP_016862621.1; XM_017007132.1.
DR RefSeq; XP_016862622.1; XM_017007133.1.
DR RefSeq; XP_016862623.1; XM_017007134.1.
DR RefSeq; XP_016862624.1; XM_017007135.1.
DR RefSeq; XP_016862625.1; XM_017007136.1.
DR AlphaFoldDB; P51504; -.
DR SMR; P51504; -.
DR BioGRID; 113452; 10.
DR IntAct; P51504; 9.
DR STRING; 9606.ENSP00000417192; -.
DR iPTMnet; P51504; -.
DR PhosphoSitePlus; P51504; -.
DR BioMuta; ZNF80; -.
DR DMDM; 206729946; -.
DR MassIVE; P51504; -.
DR MaxQB; P51504; -.
DR PaxDb; P51504; -.
DR PeptideAtlas; P51504; -.
DR PRIDE; P51504; -.
DR ProteomicsDB; 56310; -.
DR Antibodypedia; 32644; 22 antibodies from 11 providers.
DR DNASU; 7634; -.
DR Ensembl; ENST00000308095.4; ENSP00000309812.4; ENSG00000174255.8.
DR Ensembl; ENST00000482457.4; ENSP00000417192.3; ENSG00000174255.8.
DR GeneID; 7634; -.
DR KEGG; hsa:7634; -.
DR MANE-Select; ENST00000482457.4; ENSP00000417192.3; NM_007136.4; NP_009067.2.
DR UCSC; uc010hqo.5; human.
DR CTD; 7634; -.
DR DisGeNET; 7634; -.
DR GeneCards; ZNF80; -.
DR HGNC; HGNC:13155; ZNF80.
DR HPA; ENSG00000174255; Tissue enriched (lymphoid).
DR MIM; 194553; gene.
DR neXtProt; NX_P51504; -.
DR OpenTargets; ENSG00000174255; -.
DR PharmGKB; PA37729; -.
DR VEuPathDB; HostDB:ENSG00000174255; -.
DR eggNOG; KOG1721; Eukaryota.
DR GeneTree; ENSGT00940000164925; -.
DR HOGENOM; CLU_002678_2_1_1; -.
DR InParanoid; P51504; -.
DR OMA; YHSVFFR; -.
DR OrthoDB; 1133009at2759; -.
DR PhylomeDB; P51504; -.
DR TreeFam; TF337055; -.
DR PathwayCommons; P51504; -.
DR SignaLink; P51504; -.
DR BioGRID-ORCS; 7634; 14 hits in 1097 CRISPR screens.
DR GenomeRNAi; 7634; -.
DR Pharos; P51504; Tdark.
DR PRO; PR:P51504; -.
DR Proteomes; UP000005640; Chromosome 3.
DR RNAct; P51504; protein.
DR Bgee; ENSG00000174255; Expressed in granulocyte and 52 other tissues.
DR Genevisible; P51504; HS.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0000977; F:RNA polymerase II transcription regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR InterPro; IPR036236; Znf_C2H2_sf.
DR InterPro; IPR013087; Znf_C2H2_type.
DR Pfam; PF00096; zf-C2H2; 4.
DR SMART; SM00355; ZnF_C2H2; 7.
DR SUPFAM; SSF57667; SSF57667; 4.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 5.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 7.
PE 1: Evidence at protein level;
KW DNA-binding; Metal-binding; Nucleus; Reference proteome; Repeat;
KW Transcription; Transcription regulation; Zinc; Zinc-finger.
FT CHAIN 1..273
FT /note="Zinc finger protein 80"
FT /id="PRO_0000047391"
FT ZN_FING 49..71
FT /note="C2H2-type 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 77..99
FT /note="C2H2-type 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 105..127
FT /note="C2H2-type 3; atypical"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 133..155
FT /note="C2H2-type 4"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 161..183
FT /note="C2H2-type 5"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 189..211
FT /note="C2H2-type 6"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 217..239
FT /note="C2H2-type 7"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT VARIANT 201
FT /note="R -> H (in dbSNP:rs6438191)"
FT /id="VAR_046561"
FT VARIANT 253
FT /note="D -> A (in dbSNP:rs3732782)"
FT /id="VAR_019972"
FT CONFLICT 95
FT /note="P -> H (in Ref. 1; CAA46340)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 273 AA; 31224 MW; 16A1CA82DCE2F579 CRC64;
MSPKRDGLGT GDGLHSQVLQ EQVSTGDNLH ECDSQGPSKD TLVREGKTYK CKECGSVFNK
NSLLVRHQQI HTGVKPYECQ ECGKAFPEKV DFVRPMRIHT GEKPCKCVEC GKVFNRRSHL
LCYRQIHTGE KPYECSECGK TFSYHSVFIQ HRVTHTGEKL FGCKECGKTF YYNSSLTRHM
KIHTGEKPCK CSECGKTFTY RSVFFRHSMT HTAGKPYECK ECGKGFYYSY SLTRHTRSHT
GEKPYECLEH RKDFGYHSAF AQQSKIHSGG KNL
