ZNF83_HUMAN
ID ZNF83_HUMAN Reviewed; 516 AA.
AC P51522; A8MT75; Q3ZCX0; Q6PI08;
DT 01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
DT 13-JUL-2010, sequence version 3.
DT 03-AUG-2022, entry version 183.
DE RecName: Full=Zinc finger protein 83;
DE AltName: Full=Zinc finger protein 816B;
DE AltName: Full=Zinc finger protein HPF1;
GN Name=ZNF83; Synonyms=ZNF816B;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), AND VARIANT ASN-96.
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15057824; DOI=10.1038/nature02399;
RA Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E.,
RA Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A.,
RA Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S.,
RA Carrano A.V., Caoile C., Chan Y.M., Christensen M., Cleland C.A.,
RA Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J.,
RA Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M.,
RA Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W.,
RA Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V.,
RA Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D.,
RA McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I.,
RA Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L.,
RA Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A.,
RA She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M.,
RA Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J.,
RA Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E.,
RA Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M.,
RA Rubin E.M., Lucas S.M.;
RT "The DNA sequence and biology of human chromosome 19.";
RL Nature 428:529-535(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2), AND VARIANTS
RP ASN-96 AND ARG-392.
RC TISSUE=PNS;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 89-428 (ISOFORM 1), AND VARIANT ASN-96.
RC TISSUE=Placenta;
RX PubMed=2505992; DOI=10.1089/dna.1.1989.8.377;
RA Bellefroid E.J., Lecocq P.J., Benhida A., Poncelet D.A., Belayew A.,
RA Martial J.A.;
RT "The human genome contains hundreds of genes coding for finger proteins of
RT the Kruppel type.";
RL DNA 8:377-387(1989).
CC -!- FUNCTION: May be involved in transcriptional regulation.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=P51522-1; Sequence=Displayed;
CC Name=2;
CC IsoId=P51522-2; Sequence=VSP_037663;
CC -!- SIMILARITY: Belongs to the krueppel C2H2-type zinc-finger protein
CC family. {ECO:0000305}.
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DR EMBL; AK289399; BAF82088.1; -; mRNA.
DR EMBL; AC022150; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC050407; AAH50407.1; -; mRNA.
DR EMBL; BC032867; AAH32867.1; -; mRNA.
DR EMBL; M27877; AAG41760.1; -; mRNA.
DR CCDS; CCDS12854.1; -. [P51522-1]
DR PIR; A32891; A32891.
DR RefSeq; NP_001099019.1; NM_001105549.1. [P51522-1]
DR RefSeq; NP_001099020.1; NM_001105550.1. [P51522-1]
DR RefSeq; NP_001099021.1; NM_001105551.1. [P51522-1]
DR RefSeq; NP_001099022.1; NM_001105552.1. [P51522-1]
DR RefSeq; NP_001264874.1; NM_001277945.1. [P51522-1]
DR RefSeq; NP_001264875.1; NM_001277946.1. [P51522-1]
DR RefSeq; NP_001264876.1; NM_001277947.1. [P51522-1]
DR RefSeq; NP_001264877.1; NM_001277948.1. [P51522-1]
DR RefSeq; NP_001264878.1; NM_001277949.1. [P51522-1]
DR RefSeq; NP_001264880.1; NM_001277951.1. [P51522-1]
DR RefSeq; NP_001264881.1; NM_001277952.1. [P51522-1]
DR RefSeq; NP_001334944.1; NM_001348015.1. [P51522-1]
DR RefSeq; NP_001334945.1; NM_001348016.1. [P51522-1]
DR RefSeq; NP_001334946.1; NM_001348017.1. [P51522-1]
DR RefSeq; NP_001334947.1; NM_001348018.1. [P51522-1]
DR RefSeq; NP_001334948.1; NM_001348019.1. [P51522-1]
DR RefSeq; NP_060770.3; NM_018300.3. [P51522-1]
DR AlphaFoldDB; P51522; -.
DR SMR; P51522; -.
DR BioGRID; 120886; 6.
DR IntAct; P51522; 5.
DR MINT; P51522; -.
DR STRING; 9606.ENSP00000472619; -.
DR iPTMnet; P51522; -.
DR PhosphoSitePlus; P51522; -.
DR BioMuta; ZNF83; -.
DR DMDM; 300669707; -.
DR jPOST; P51522; -.
DR MassIVE; P51522; -.
DR PaxDb; P51522; -.
DR PeptideAtlas; P51522; -.
DR PRIDE; P51522; -.
DR ProteomicsDB; 56319; -. [P51522-1]
DR ProteomicsDB; 56320; -. [P51522-2]
DR Antibodypedia; 19113; 121 antibodies from 17 providers.
DR DNASU; 55769; -.
DR Ensembl; ENST00000301096.8; ENSP00000301096.3; ENSG00000167766.20. [P51522-1]
DR Ensembl; ENST00000545872.1; ENSP00000440713.1; ENSG00000167766.20. [P51522-1]
DR Ensembl; ENST00000597597.1; ENSP00000472619.1; ENSG00000167766.20. [P51522-1]
DR GeneID; 55769; -.
DR KEGG; hsa:55769; -.
DR UCSC; uc002pzu.5; human. [P51522-1]
DR CTD; 55769; -.
DR GeneCards; ZNF83; -.
DR HGNC; HGNC:13158; ZNF83.
DR HPA; ENSG00000167766; Low tissue specificity.
DR MIM; 194558; gene.
DR neXtProt; NX_P51522; -.
DR OpenTargets; ENSG00000167766; -.
DR PharmGKB; PA37731; -.
DR VEuPathDB; HostDB:ENSG00000167766; -.
DR eggNOG; KOG1721; Eukaryota.
DR GeneTree; ENSGT00940000163013; -.
DR HOGENOM; CLU_002678_44_4_1; -.
DR InParanoid; P51522; -.
DR OMA; THVSHTH; -.
DR PhylomeDB; P51522; -.
DR TreeFam; TF341892; -.
DR PathwayCommons; P51522; -.
DR SignaLink; P51522; -.
DR BioGRID-ORCS; 55769; 27 hits in 1095 CRISPR screens.
DR ChiTaRS; ZNF83; human.
DR GeneWiki; ZNF83; -.
DR GenomeRNAi; 55769; -.
DR Pharos; P51522; Tdark.
DR PRO; PR:P51522; -.
DR Proteomes; UP000005640; Chromosome 19.
DR RNAct; P51522; protein.
DR Bgee; ENSG00000167766; Expressed in right uterine tube and 194 other tissues.
DR ExpressionAtlas; P51522; baseline and differential.
DR Genevisible; P51522; HS.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR InterPro; IPR036236; Znf_C2H2_sf.
DR InterPro; IPR013087; Znf_C2H2_type.
DR Pfam; PF00096; zf-C2H2; 14.
DR SMART; SM00355; ZnF_C2H2; 15.
DR SUPFAM; SSF57667; SSF57667; 8.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 14.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 15.
PE 2: Evidence at transcript level;
KW Alternative splicing; DNA-binding; Metal-binding; Nucleus;
KW Reference proteome; Repeat; Transcription; Transcription regulation; Zinc;
KW Zinc-finger.
FT CHAIN 1..516
FT /note="Zinc finger protein 83"
FT /id="PRO_0000047396"
FT ZN_FING 93..115
FT /note="C2H2-type 1; degenerate"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 121..143
FT /note="C2H2-type 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 149..171
FT /note="C2H2-type 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 177..199
FT /note="C2H2-type 4"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 205..227
FT /note="C2H2-type 5"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 233..255
FT /note="C2H2-type 6"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 261..283
FT /note="C2H2-type 7"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 289..311
FT /note="C2H2-type 8"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 317..339
FT /note="C2H2-type 9"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 345..367
FT /note="C2H2-type 10"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 373..395
FT /note="C2H2-type 11"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 401..423
FT /note="C2H2-type 12"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 429..451
FT /note="C2H2-type 13"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 457..479
FT /note="C2H2-type 14"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 485..507
FT /note="C2H2-type 15"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT REGION 1..20
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 271..298
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:14702039,
FT ECO:0000303|PubMed:15489334"
FT /id="VSP_037663"
FT VARIANT 70
FT /note="T -> I (in dbSNP:rs3786490)"
FT /id="VAR_058206"
FT VARIANT 96
FT /note="S -> N (in dbSNP:rs1056185)"
FT /evidence="ECO:0000269|PubMed:14702039,
FT ECO:0000269|PubMed:15489334, ECO:0000269|PubMed:2505992"
FT /id="VAR_058207"
FT VARIANT 119
FT /note="T -> M (in dbSNP:rs329940)"
FT /id="VAR_058208"
FT VARIANT 392
FT /note="H -> R (in dbSNP:rs11545619)"
FT /evidence="ECO:0000269|PubMed:15489334"
FT /id="VAR_058209"
FT CONFLICT 89..91
FT /note="GTE -> MDR (in Ref. 4; AAG41760)"
FT /evidence="ECO:0000305"
FT CONFLICT 108..109
FT /note="FT -> LP (in Ref. 4; AAG41760)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 516 AA; 59710 MW; A6CA428CFAEA5D69 CRC64;
MHGRKDDAQK QPVKNQLGLN PQSHLPELQL FQAEGKIYKY DHMEKSVNSS SLVSPPQRIS
STVKTHISHT YECNFVDSLF TQKEKANIGT EHYKCSERGK AFHQGLHFTI HQIIHTKETQ
FKCDICGKIF NKKSNLASHQ RIHTGEKPYK CNECGKVFHN MSHLAQHRRI HTGEKPYKCN
ECGKVFNQIS HLAQHQRIHT GEKPYKCNEC GKVFHQISHL AQHRTIHTGE KPYECNKCGK
VFSRNSYLVQ HLIIHTGEKP YRCNVCGKVF HHISHLAQHQ RIHTGEKPYK CNECGKVFSH
KSSLVNHWRI HTGEKPYKCN ECGKVFSHKS SLVNHWRIHT GEKPYKCNEC GKVFSRNSYL
AQHLIIHAGE KPYKCDECDK AFSQNSHLVQ HHRIHTGEKP YKCDECGKVF SQNSYLAYHW
RIHTGEKAYK CNECGKVFGL NSSLAHHRKI HTGEKPFKCN ECGKAFSMRS SLTNHHAIHT
GEKHFKCNEC GKLFRDNSYL VRHQRFHAGK KSNTCN
