ZNF90_HUMAN
ID ZNF90_HUMAN Reviewed; 601 AA.
AC Q03938; B9EH87;
DT 01-JUN-1994, integrated into UniProtKB/Swiss-Prot.
DT 13-JUL-2010, sequence version 3.
DT 03-AUG-2022, entry version 174.
DE RecName: Full=Zinc finger protein 90;
DE AltName: Full=Zinc finger protein HTF9;
GN Name=ZNF90;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15057824; DOI=10.1038/nature02399;
RA Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E.,
RA Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A.,
RA Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S.,
RA Carrano A.V., Caoile C., Chan Y.M., Christensen M., Cleland C.A.,
RA Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J.,
RA Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M.,
RA Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W.,
RA Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V.,
RA Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D.,
RA McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I.,
RA Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L.,
RA Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A.,
RA She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M.,
RA Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J.,
RA Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E.,
RA Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M.,
RA Rubin E.M., Lucas S.M.;
RT "The DNA sequence and biology of human chromosome 19.";
RL Nature 428:529-535(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 1-217.
RX PubMed=15146197; DOI=10.1038/nbt971;
RA Brandenberger R., Wei H., Zhang S., Lei S., Murage J., Fisk G.J., Li Y.,
RA Xu C., Fang R., Guegler K., Rao M.S., Mandalam R., Lebkowski J.,
RA Stanton L.W.;
RT "Transcriptome characterization elucidates signaling networks that control
RT human ES cell growth and differentiation.";
RL Nat. Biotechnol. 22:707-716(2004).
RN [4]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 1-195.
RX PubMed=2023909; DOI=10.1073/pnas.88.9.3608;
RA Bellefroid E.J., Poncelet D.A., Lecocq P.J., Revelant O., Martial J.A.;
RT "The evolutionarily conserved Kruppel-associated box domain defines a
RT subfamily of eukaryotic multifingered proteins.";
RL Proc. Natl. Acad. Sci. U.S.A. 88:3608-3612(1991).
CC -!- FUNCTION: May be involved in transcriptional regulation.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC -!- DEVELOPMENTAL STAGE: Expressed early during embryonic development.
CC -!- SIMILARITY: Belongs to the krueppel C2H2-type zinc-finger protein
CC family. {ECO:0000305}.
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DR EMBL; AC011447; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC137211; AAI37212.1; -; mRNA.
DR EMBL; CN386341; -; NOT_ANNOTATED_CDS; mRNA.
DR EMBL; M61870; AAA36028.1; -; mRNA.
DR CCDS; CCDS46028.1; -.
DR PIR; E39384; E39384.
DR RefSeq; NP_009069.1; NM_007138.1.
DR AlphaFoldDB; Q03938; -.
DR SMR; Q03938; -.
DR BioGRID; 113459; 1.
DR STRING; 9606.ENSP00000410466; -.
DR iPTMnet; Q03938; -.
DR PhosphoSitePlus; Q03938; -.
DR BioMuta; ZNF90; -.
DR DMDM; 300669708; -.
DR EPD; Q03938; -.
DR jPOST; Q03938; -.
DR MassIVE; Q03938; -.
DR MaxQB; Q03938; -.
DR PaxDb; Q03938; -.
DR PeptideAtlas; Q03938; -.
DR PRIDE; Q03938; -.
DR ProteomicsDB; 58233; -.
DR Antibodypedia; 28581; 100 antibodies from 17 providers.
DR DNASU; 7643; -.
DR Ensembl; ENST00000418063.3; ENSP00000410466.2; ENSG00000213988.11.
DR GeneID; 7643; -.
DR KEGG; hsa:7643; -.
DR MANE-Select; ENST00000418063.3; ENSP00000410466.2; NM_007138.2; NP_009069.1.
DR UCSC; uc002nor.3; human.
DR CTD; 7643; -.
DR DisGeNET; 7643; -.
DR GeneCards; ZNF90; -.
DR HGNC; HGNC:13165; ZNF90.
DR HPA; ENSG00000213988; Low tissue specificity.
DR MIM; 603973; gene.
DR neXtProt; NX_Q03938; -.
DR OpenTargets; ENSG00000213988; -.
DR PharmGKB; PA37738; -.
DR VEuPathDB; HostDB:ENSG00000213988; -.
DR eggNOG; KOG1721; Eukaryota.
DR GeneTree; ENSGT00940000153236; -.
DR HOGENOM; CLU_002678_44_0_1; -.
DR InParanoid; Q03938; -.
DR OMA; HIGQKAY; -.
DR OrthoDB; 1318335at2759; -.
DR PhylomeDB; Q03938; -.
DR TreeFam; TF342117; -.
DR PathwayCommons; Q03938; -.
DR BioGRID-ORCS; 7643; 11 hits in 1022 CRISPR screens.
DR ChiTaRS; ZNF90; human.
DR GenomeRNAi; 7643; -.
DR Pharos; Q03938; Tbio.
DR PRO; PR:Q03938; -.
DR Proteomes; UP000005640; Chromosome 19.
DR RNAct; Q03938; protein.
DR Bgee; ENSG00000213988; Expressed in buccal mucosa cell and 95 other tissues.
DR ExpressionAtlas; Q03938; baseline and differential.
DR Genevisible; Q03938; HS.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; NAS:UniProtKB.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0008270; F:zinc ion binding; NAS:UniProtKB.
DR GO; GO:0006355; P:regulation of transcription, DNA-templated; IBA:GO_Central.
DR CDD; cd07765; KRAB_A-box; 1.
DR InterPro; IPR001909; KRAB.
DR InterPro; IPR036051; KRAB_dom_sf.
DR InterPro; IPR036236; Znf_C2H2_sf.
DR InterPro; IPR013087; Znf_C2H2_type.
DR Pfam; PF01352; KRAB; 1.
DR Pfam; PF00096; zf-C2H2; 14.
DR SMART; SM00349; KRAB; 1.
DR SMART; SM00355; ZnF_C2H2; 15.
DR SUPFAM; SSF109640; SSF109640; 1.
DR SUPFAM; SSF57667; SSF57667; 8.
DR PROSITE; PS50805; KRAB; 1.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 15.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 15.
PE 2: Evidence at transcript level;
KW DNA-binding; Metal-binding; Nucleus; Reference proteome; Repeat;
KW Transcription; Transcription regulation; Zinc; Zinc-finger.
FT CHAIN 1..601
FT /note="Zinc finger protein 90"
FT /id="PRO_0000047399"
FT DOMAIN 4..75
FT /note="KRAB"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00119"
FT ZN_FING 173..195
FT /note="C2H2-type 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 201..223
FT /note="C2H2-type 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 229..251
FT /note="C2H2-type 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 257..279
FT /note="C2H2-type 4"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 285..307
FT /note="C2H2-type 5"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 313..335
FT /note="C2H2-type 6"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 341..363
FT /note="C2H2-type 7"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 369..391
FT /note="C2H2-type 8"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 397..419
FT /note="C2H2-type 9"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 425..447
FT /note="C2H2-type 10"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 453..475
FT /note="C2H2-type 11"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 481..503
FT /note="C2H2-type 12"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 509..531
FT /note="C2H2-type 13"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 537..559
FT /note="C2H2-type 14"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 565..587
FT /note="C2H2-type 15"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
SQ SEQUENCE 601 AA; 69058 MW; DEF44E0762A0C74D CRC64;
MGPLEFRDVA IEFSLEEWHC LDTAQQNLYR DVMLENYRHL VFLGIVVTKP DLITCLEQGK
KPFTVKRHEM IAKSPVMCFH FAQDLCPEQS LKDSFQKVIV TRYEKREYGN LELKKGCESV
DEGKVHKRGY NGLNQCLTAT QSKVFQCDTY VKVSHIFSNS NRHKIRDTGK KPFKCIECGK
AFNQSSTLAT HKKIHTGEIT CKCEECGKAF NRSSHLTSHK RIHTGEKRYK CEDCGKELKY
SSTLTAHKRI HTGEKRYKCE DCGKELKYSS TLTAHKRIHT GEKPYKCDKC GRAFISSSIL
YVHKISHTEE KPYKCEECGK AFKLSSILST HKRIHTGEKP YKCEECGKAF RRSLVLRTHK
RIHTGEKPYK CDKCGKAFIS SSLLYKHKIS HSEKKPYKCE ECGKAFKRSS TLTIHKISHT
EEKPYKCQEC DKVFKRSSAL STHKIIHSGE KPYKCEECGK AFKRSSNLTT HKISHTEEKL
YKCQECDKAF KYSSALSTHK IIHSGENPYK CEECGKAFKR SSVLSKHKII HTGAKPYKCE
ECGKAFKRSS QLTSHKISHT GEKPYKCEEC GKAFNLSSDL NTHKRIHIGQ KAYIVKNMAN
L
