ZNF92_HUMAN
ID ZNF92_HUMAN Reviewed; 586 AA.
AC Q03936; A6NNF9; Q8N492; Q8NB35;
DT 01-JUN-1994, integrated into UniProtKB/Swiss-Prot.
DT 10-JAN-2006, sequence version 2.
DT 03-AUG-2022, entry version 194.
DE RecName: Full=Zinc finger protein 92;
DE AltName: Full=Zinc finger protein HTF12;
GN Name=ZNF92;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC TISSUE=Brain;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=12853948; DOI=10.1038/nature01782;
RA Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H.,
RA Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K.,
RA Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A.,
RA Delehaunty K.D., Miner T.L., Nash W.E., Cordes M., Du H., Sun H.,
RA Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A.,
RA Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P.,
RA Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M.,
RA Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S.,
RA Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R.,
RA Strowmatt C., Latreille P., Miller N., Johnson D., Murray J.,
RA Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W.,
RA Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E.,
RA Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A.,
RA Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E.,
RA Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E.,
RA Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A.,
RA Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A.,
RA Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R.,
RA McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H.,
RA Wilson R.K.;
RT "The DNA sequence of human chromosome 7.";
RL Nature 424:157-164(2003).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2), AND VARIANT
RP ARG-492.
RC TISSUE=Brain, and Testis;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 1-195 (ISOFORM 3).
RX PubMed=2023909; DOI=10.1073/pnas.88.9.3608;
RA Bellefroid E.J., Poncelet D.A., Lecocq P.J., Revelant O., Martial J.A.;
RT "The evolutionarily conserved Kruppel-associated box domain defines a
RT subfamily of eukaryotic multifingered proteins.";
RL Proc. Natl. Acad. Sci. U.S.A. 88:3608-3612(1991).
CC -!- FUNCTION: May be involved in transcriptional regulation.
CC -!- INTERACTION:
CC Q03936; Q6FHY5: MEOX2; NbExp=3; IntAct=EBI-12176441, EBI-16439278;
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=3;
CC Name=1;
CC IsoId=Q03936-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q03936-2; Sequence=VSP_016964;
CC Name=3;
CC IsoId=Q03936-3; Sequence=VSP_016965;
CC -!- DEVELOPMENTAL STAGE: Expressed early during embryonic development.
CC -!- SIMILARITY: Belongs to the krueppel C2H2-type zinc-finger protein
CC family. {ECO:0000305}.
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DR EMBL; AK091618; BAC03708.1; -; mRNA.
DR EMBL; AC092685; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC036439; AAH36439.1; -; mRNA.
DR EMBL; BC040594; AAH40594.1; -; mRNA.
DR EMBL; M61872; AAA58673.1; -; mRNA.
DR CCDS; CCDS34646.1; -. [Q03936-1]
DR CCDS; CCDS47596.1; -. [Q03936-2]
DR CCDS; CCDS75608.1; -. [Q03936-3]
DR PIR; G39384; G39384.
DR RefSeq; NP_001274461.1; NM_001287532.1. [Q03936-3]
DR RefSeq; NP_001274462.1; NM_001287533.1.
DR RefSeq; NP_001274463.1; NM_001287534.1.
DR RefSeq; NP_009070.2; NM_007139.3. [Q03936-2]
DR RefSeq; NP_689839.1; NM_152626.3. [Q03936-1]
DR AlphaFoldDB; Q03936; -.
DR SMR; Q03936; -.
DR BioGRID; 127958; 57.
DR IntAct; Q03936; 19.
DR STRING; 9606.ENSP00000332595; -.
DR iPTMnet; Q03936; -.
DR PhosphoSitePlus; Q03936; -.
DR BioMuta; ZNF92; -.
DR DMDM; 85681871; -.
DR EPD; Q03936; -.
DR jPOST; Q03936; -.
DR MassIVE; Q03936; -.
DR MaxQB; Q03936; -.
DR PaxDb; Q03936; -.
DR PeptideAtlas; Q03936; -.
DR PRIDE; Q03936; -.
DR ProteomicsDB; 58230; -. [Q03936-1]
DR ProteomicsDB; 58231; -. [Q03936-2]
DR ProteomicsDB; 58232; -. [Q03936-3]
DR Antibodypedia; 14040; 86 antibodies from 18 providers.
DR DNASU; 168374; -.
DR Ensembl; ENST00000328747.12; ENSP00000332595.8; ENSG00000146757.14. [Q03936-1]
DR Ensembl; ENST00000357512.3; ENSP00000350113.2; ENSG00000146757.14. [Q03936-3]
DR Ensembl; ENST00000450302.2; ENSP00000396126.2; ENSG00000146757.14. [Q03936-2]
DR GeneID; 168374; -.
DR KEGG; hsa:168374; -.
DR MANE-Select; ENST00000328747.12; ENSP00000332595.8; NM_152626.4; NP_689839.1.
DR UCSC; uc003tua.5; human. [Q03936-1]
DR CTD; 168374; -.
DR DisGeNET; 168374; -.
DR GeneCards; ZNF92; -.
DR HGNC; HGNC:13168; ZNF92.
DR HPA; ENSG00000146757; Low tissue specificity.
DR MIM; 603974; gene.
DR neXtProt; NX_Q03936; -.
DR OpenTargets; ENSG00000146757; -.
DR PharmGKB; PA37740; -.
DR VEuPathDB; HostDB:ENSG00000146757; -.
DR eggNOG; KOG1721; Eukaryota.
DR GeneTree; ENSGT01050000244908; -.
DR HOGENOM; CLU_002678_57_1_1; -.
DR InParanoid; Q03936; -.
DR OMA; HEMVDKT; -.
DR PhylomeDB; Q03936; -.
DR TreeFam; TF342117; -.
DR PathwayCommons; Q03936; -.
DR Reactome; R-HSA-212436; Generic Transcription Pathway.
DR SignaLink; Q03936; -.
DR BioGRID-ORCS; 168374; 6 hits in 1028 CRISPR screens.
DR ChiTaRS; ZNF92; human.
DR GenomeRNAi; 168374; -.
DR Pharos; Q03936; Tbio.
DR PRO; PR:Q03936; -.
DR Proteomes; UP000005640; Chromosome 7.
DR RNAct; Q03936; protein.
DR Bgee; ENSG00000146757; Expressed in endothelial cell and 184 other tissues.
DR ExpressionAtlas; Q03936; baseline and differential.
DR Genevisible; Q03936; HS.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; NAS:UniProtKB.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0008270; F:zinc ion binding; NAS:UniProtKB.
DR GO; GO:0006355; P:regulation of transcription, DNA-templated; IBA:GO_Central.
DR CDD; cd07765; KRAB_A-box; 1.
DR InterPro; IPR001909; KRAB.
DR InterPro; IPR036051; KRAB_dom_sf.
DR InterPro; IPR036236; Znf_C2H2_sf.
DR InterPro; IPR013087; Znf_C2H2_type.
DR Pfam; PF01352; KRAB; 1.
DR Pfam; PF00096; zf-C2H2; 10.
DR SMART; SM00349; KRAB; 1.
DR SMART; SM00355; ZnF_C2H2; 13.
DR SUPFAM; SSF109640; SSF109640; 1.
DR SUPFAM; SSF57667; SSF57667; 9.
DR PROSITE; PS50805; KRAB; 1.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 11.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 14.
PE 1: Evidence at protein level;
KW Alternative splicing; DNA-binding; Metal-binding; Nucleus;
KW Reference proteome; Repeat; Transcription; Transcription regulation; Zinc;
KW Zinc-finger.
FT CHAIN 1..586
FT /note="Zinc finger protein 92"
FT /id="PRO_0000047401"
FT DOMAIN 4..75
FT /note="KRAB"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00119"
FT ZN_FING 145..167
FT /note="C2H2-type 1; degenerate"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 173..195
FT /note="C2H2-type 2; degenerate"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 201..223
FT /note="C2H2-type 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 229..251
FT /note="C2H2-type 4"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 257..279
FT /note="C2H2-type 5"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 285..307
FT /note="C2H2-type 6"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 313..335
FT /note="C2H2-type 7"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 341..363
FT /note="C2H2-type 8"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 369..391
FT /note="C2H2-type 9"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 397..419
FT /note="C2H2-type 10"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 425..447
FT /note="C2H2-type 11"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 453..475
FT /note="C2H2-type 12"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 481..503
FT /note="C2H2-type 13"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 509..531
FT /note="C2H2-type 14; degenerate"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 537..559
FT /note="C2H2-type 15; degenerate"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 563..586
FT /note="C2H2-type 16; degenerate"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT VAR_SEQ 1..69
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_016964"
FT VAR_SEQ 44..75
FT /note="Missing (in isoform 3)"
FT /evidence="ECO:0000303|PubMed:2023909"
FT /id="VSP_016965"
FT VARIANT 122
FT /note="A -> V (in dbSNP:rs10265083)"
FT /id="VAR_052766"
FT VARIANT 492
FT /note="Q -> R (in dbSNP:rs17853615)"
FT /evidence="ECO:0000269|PubMed:15489334"
FT /id="VAR_024843"
FT VARIANT 527
FT /note="R -> H (in dbSNP:rs10239197)"
FT /id="VAR_052767"
FT CONFLICT 25..26
FT /note="QR -> PG (in Ref. 4; AAA58673)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 586 AA; 68487 MW; DEDD12A611676857 CRC64;
MGPLTFRDVK IEFSLEEWQC LDTAQRNLYR DVMLENYRNL VFLGIAVSKP DLITWLEQGK
EPWNLKRHEM VDKTPVMCSH FAQDVWPEHS IKDSFQKVIL RTYGKYGHEN LQLRKDHKSV
DACKVYKGGY NGLNQCLTTT DSKIFQCDKY VKVFHKFPNV NRNKIRHTGK KPFKCKNRGK
SFCMLSQLTQ HKKIHTREYS YKCEECGKAF NWSSTLTKHK IIHTGEKPYK CEECGKAFNR
SSNLTKHKII HTGEKPYKCE ECGKAFNRSS TLTKHKRIHT EEKPYKCEEC GKAFNQFSIL
NKHKRIHMED KPYKCEECGK AFRVFSILKK HKIIHTGEKP YKCEECGKAF NQFSNLTKHK
IIHTGEKPYK CDECGKAFNQ SSTLTKHKRI HTGEKPYKCE ECGKAFKQSS TLTEHKIIHT
GEKPYKCEKC GKAFSWSSAF TKHKRNHMED KPYKCEECGK AFSVFSTLTK HKIIHTREKP
YKCEECGKAF NQSSIFTKHK IIHTEGKSYK CEKCGNAFNQ SSNLTARKII YTGEKPYKYE
ECDKAFNKFS TLITHQIIYT GEKPCKHECG RAFNKSSNYT KEKLQT
