ZNF98_HUMAN
ID ZNF98_HUMAN Reviewed; 572 AA.
AC A6NK75;
DT 05-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT 08-MAR-2011, sequence version 4.
DT 03-AUG-2022, entry version 123.
DE RecName: Full=Zinc finger protein 98;
DE AltName: Full=Zinc finger protein 739;
DE AltName: Full=Zinc finger protein F7175;
GN Name=ZNF98; Synonyms=ZNF739;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15057824; DOI=10.1038/nature02399;
RA Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E.,
RA Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A.,
RA Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S.,
RA Carrano A.V., Caoile C., Chan Y.M., Christensen M., Cleland C.A.,
RA Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J.,
RA Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M.,
RA Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W.,
RA Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V.,
RA Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D.,
RA McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I.,
RA Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L.,
RA Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A.,
RA She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M.,
RA Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J.,
RA Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E.,
RA Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M.,
RA Rubin E.M., Lucas S.M.;
RT "The DNA sequence and biology of human chromosome 19.";
RL Nature 428:529-535(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-148.
RA Wambutt R., Heubner D., Mewes H.W., Weil B., Amid C., Osanger A., Fobo G.,
RA Han M., Wiemann S.;
RL Submitted (FEB-2004) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 31-572.
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP PARTIAL NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=8467795; DOI=10.1002/j.1460-2075.1993.tb05781.x;
RA Bellefroid E.J., Marine J.-C., Ried T., Lecocq P.J., Riviere M.,
RA Amemiya C.T., Poncelet D.A., Coulie P.G., de Jong P.J., Szpirer C.,
RA Ward D.C., Martial J.A.;
RT "Clustered organization of homologous KRAB zinc-finger genes with enhanced
RT expression in human T lymphoid cells.";
RL EMBO J. 12:1363-1374(1993).
CC -!- FUNCTION: May be involved in transcriptional regulation.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the krueppel C2H2-type zinc-finger protein
CC family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAI10577.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
CC Sequence=AAI29811.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
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DR EMBL; AC011516; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BX955247; -; NOT_ANNOTATED_CDS; mRNA.
DR EMBL; BC110576; AAI10577.1; ALT_INIT; mRNA.
DR EMBL; BC129810; AAI29811.1; ALT_INIT; mRNA.
DR CCDS; CCDS46031.1; -.
DR RefSeq; NP_001092096.1; NM_001098626.1.
DR AlphaFoldDB; A6NK75; -.
DR SMR; A6NK75; -.
DR STRING; 9606.ENSP00000350418; -.
DR iPTMnet; A6NK75; -.
DR PhosphoSitePlus; A6NK75; -.
DR BioMuta; ZNF98; -.
DR EPD; A6NK75; -.
DR jPOST; A6NK75; -.
DR MassIVE; A6NK75; -.
DR MaxQB; A6NK75; -.
DR PaxDb; A6NK75; -.
DR PeptideAtlas; A6NK75; -.
DR PRIDE; A6NK75; -.
DR ProteomicsDB; 1384; -.
DR Antibodypedia; 55050; 94 antibodies from 13 providers.
DR DNASU; 148198; -.
DR Ensembl; ENST00000357774.9; ENSP00000350418.4; ENSG00000197360.9.
DR GeneID; 148198; -.
DR KEGG; hsa:148198; -.
DR MANE-Select; ENST00000357774.9; ENSP00000350418.4; NM_001098626.2; NP_001092096.1.
DR UCSC; uc002nqt.3; human.
DR CTD; 148198; -.
DR DisGeNET; 148198; -.
DR GeneCards; ZNF98; -.
DR HGNC; HGNC:13174; ZNF98.
DR HPA; ENSG00000197360; Tissue enhanced (ovary, pancreas).
DR MIM; 603980; gene.
DR neXtProt; NX_A6NK75; -.
DR OpenTargets; ENSG00000197360; -.
DR VEuPathDB; HostDB:ENSG00000197360; -.
DR eggNOG; KOG1721; Eukaryota.
DR GeneTree; ENSGT01050000244908; -.
DR HOGENOM; CLU_002678_44_0_1; -.
DR InParanoid; A6NK75; -.
DR OMA; KYCKSVD; -.
DR OrthoDB; 1318335at2759; -.
DR PhylomeDB; A6NK75; -.
DR TreeFam; TF342117; -.
DR PathwayCommons; A6NK75; -.
DR SignaLink; A6NK75; -.
DR BioGRID-ORCS; 148198; 102 hits in 1012 CRISPR screens.
DR ChiTaRS; ZNF98; human.
DR GenomeRNAi; 148198; -.
DR Pharos; A6NK75; Tdark.
DR PRO; PR:A6NK75; -.
DR Proteomes; UP000005640; Chromosome 19.
DR RNAct; A6NK75; protein.
DR Bgee; ENSG00000197360; Expressed in body of pancreas and 92 other tissues.
DR ExpressionAtlas; A6NK75; baseline and differential.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0006355; P:regulation of transcription, DNA-templated; IBA:GO_Central.
DR CDD; cd07765; KRAB_A-box; 1.
DR InterPro; IPR001909; KRAB.
DR InterPro; IPR036051; KRAB_dom_sf.
DR InterPro; IPR036236; Znf_C2H2_sf.
DR InterPro; IPR013087; Znf_C2H2_type.
DR Pfam; PF01352; KRAB; 1.
DR Pfam; PF00096; zf-C2H2; 13.
DR SMART; SM00349; KRAB; 1.
DR SMART; SM00355; ZnF_C2H2; 13.
DR SUPFAM; SSF109640; SSF109640; 1.
DR SUPFAM; SSF57667; SSF57667; 7.
DR PROSITE; PS50805; KRAB; 1.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 13.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 13.
PE 2: Evidence at transcript level;
KW DNA-binding; Metal-binding; Nucleus; Reference proteome; Repeat;
KW Transcription; Transcription regulation; Zinc; Zinc-finger.
FT CHAIN 1..572
FT /note="Zinc finger protein 98"
FT /id="PRO_0000316948"
FT DOMAIN 13..84
FT /note="KRAB"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00119"
FT ZN_FING 182..204
FT /note="C2H2-type 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 210..232
FT /note="C2H2-type 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 238..260
FT /note="C2H2-type 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 266..288
FT /note="C2H2-type 4"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 294..316
FT /note="C2H2-type 5"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 322..344
FT /note="C2H2-type 6"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 350..372
FT /note="C2H2-type 7"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 378..400
FT /note="C2H2-type 8"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 406..428
FT /note="C2H2-type 9"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 434..456
FT /note="C2H2-type 10"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 462..484
FT /note="C2H2-type 11"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 490..512
FT /note="C2H2-type 12"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 518..540
FT /note="C2H2-type 13"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT CONFLICT 407
FT /note="K -> E (in Ref. 3; AAI10577/AAI29811)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 572 AA; 65799 MW; C65F15683A8876CA CRC64;
MPGPLGSLEM GVLTFRDVAL EFSLEEWQCL DTAQQNLYRN VMLENYRNLV FVGIAASKPD
LITCLEQGKE PWNVKRHEMV TEPPVVYSYF AQDLWPKQGK KNYFQKVILR TYKKCGRENL
QLRKYCKSMD ECKVHKECYN GLNQCLTTTQ NKIFQYDKYV KVFHKFSNSN RHKIGHTGKK
SFKCKECEKS FCMLSHLAQH KRIHSGEKPY KCKECGKAYN EASNLSTHKR IHTGKKPYKC
EECGKAFNRL SHLTTHKIIH TGKKPYKCEE CGKAFNQSAN LTTHKRIHTG EKPYKCEECG
RAFSQSSTLT AHKIIHAGEK PYKCEECGKA FSQSSTLTTH KIIHTGEKFY KCEECGKAFS
RLSHLTTHKR IHSGEKPYKC EECGKAFKQS STLTTHKRIH AGEKFYKCEV CSKAFSRFSH
LTTHKRIHTG EKPYKCEECG KAFNLSSQLT THKIIHTGEK PYKCEECGKA FNQSSTLSKH
KVIHTGEKPY KCEECGKAFN QSSHLTTHKM IHTGEKPYKC EECGKAFNNS SILNRHKMIH
TGEKLYKPES CNNACDNIAK ISKYKRNCAG EK
