ID   CCAP_PERAM              Reviewed;         171 AA.
AC   Q75UG5;
DT   31-AUG-2004, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   25-MAY-2022, entry version 44.
DE   RecName: Full=Cardioactive peptide;
DE   AltName: Full=Cardioacceleratory peptide 2a;
DE   AltName: Full=Crustacean cardioactive peptide;
DE            Short=CCAP;
DE   Flags: Precursor;
GN   Name=CCAP {ECO:0000312|EMBL:BAD18887.1};
OS   Periplaneta americana (American cockroach) (Blatta americana).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Polyneoptera; Dictyoptera; Blattodea; Blattoidea; Blattidae;
OC   Blattinae; Periplaneta.
OX   NCBI_TaxID=6978;
RN   [1] {ECO:0000312|EMBL:BAD18887.1}
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Ventral nerve cord;
RA   Sakai T., Satake H., Minakata H., Takeda M.;
RT   "CCAP cDNA of Periplaneta americana.";
RL   Submitted (NOV-2003) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000305}
RP   TISSUE SPECIFICITY.
RC   TISSUE=Ventral nerve cord {ECO:0000269|PubMed:12271490};
RX   PubMed=12271490; DOI=10.1002/cne.10357;
RA   Honegger H.W., Market D., Pierce L.A., Dewey E.M., Kostron B., Wilson M.,
RA   Choi D., Klukas K.A., Mesce K.A.;
RT   "Cellular localization of bursicon using antisera against partial peptide
RT   sequences of this insect cuticle-sclerotizing neurohormone.";
RL   J. Comp. Neurol. 452:163-177(2002).
CC   -!- FUNCTION: Cardioregulatory neurohormone that increases heart beat rate
CC       during adult wing inflation; has no effect on beat amplitude. The
CC       effect of CCAP is both ino- and chronotropic (By similarity).
CC       {ECO:0000250|UniProtKB:Q8WRC7}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:Q8WRC7}.
CC   -!- TISSUE SPECIFICITY: Central nervous system; most neurons exhibit
CC       coexpression with burs. {ECO:0000269|PubMed:12271490}.
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DR   EMBL; AB126034; BAD18887.1; -; mRNA.
DR   AlphaFoldDB; Q75UG5; -.
DR   BRENDA; 3.2.1.1; 4685.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0005179; F:hormone activity; IEA:UniProtKB-KW.
DR   GO; GO:0007218; P:neuropeptide signaling pathway; IEA:UniProtKB-KW.
DR   InterPro; IPR024276; CCAP.
DR   Pfam; PF11105; CCAP; 2.
PE   2: Evidence at transcript level;
KW   Amidation; Cleavage on pair of basic residues; Disulfide bond; Hormone;
KW   Neuropeptide; Secreted; Signal.
FT   SIGNAL          1..26
FT                   /evidence="ECO:0000255"
FT   PROPEP          27..49
FT                   /evidence="ECO:0000250|UniProtKB:Q8WRC7, ECO:0000255"
FT                   /id="PRO_0000020857"
FT   PEPTIDE         52..60
FT                   /note="Cardioactive peptide"
FT                   /evidence="ECO:0000250|UniProtKB:Q8WRC7"
FT                   /id="PRO_0000020858"
FT   PROPEP          64..171
FT                   /evidence="ECO:0000250|UniProtKB:Q8WRC7"
FT                   /id="PRO_0000020859"
FT   REGION          116..171
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        151..171
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         60
FT                   /note="Cysteine amide"
FT                   /evidence="ECO:0000250"
FT   DISULFID        54..60
FT                   /evidence="ECO:0000250|UniProtKB:Q8WRC7"
SQ   SEQUENCE   171 AA;  19466 MW;  77278AEB48846207 CRC64;
     MQMYHVVLGC SLAILLVILD IPQASCDDVV IQKRQVDPAE MDRLLDPKRK RPFCNAFTGC
     GKKRSDESMG TLVEMNSEPA VDDLSRQILS EVKLWEAIQE ARVELLRRRQ EQLQQQSNQF
     GAGMDRPLPL PIAGYRRKRF ADPESQAPAP HSNLPRATSQ LQEEITKPWS R