ID   ZNHI2_BOVIN             Reviewed;         399 AA.
AC   Q2TBW5;
DT   03-APR-2007, integrated into UniProtKB/Swiss-Prot.
DT   24-JAN-2006, sequence version 1.
DT   03-AUG-2022, entry version 75.
DE   RecName: Full=Zinc finger HIT domain-containing protein 2;
GN   Name=ZNHIT2;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Crossbred X Angus; TISSUE=Liver;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (NOV-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: May act as a bridging factor mediating the interaction
CC       between the R2TP/Prefoldin-like (R2TP/PFDL) complex and U5 small
CC       nuclear ribonucleoprotein (U5 snRNP) (By similarity). Required for the
CC       interaction of R2TP complex subunit RPAP3 and prefoldin-like subunit
CC       URI1 with U5 snRNP proteins EFTUD2 and PRPF8 (By similarity). May play
CC       a role in regulating the composition of the U5 snRNP complex (By
CC       similarity). {ECO:0000250|UniProtKB:Q9UHR6}.
CC   -!- SUBUNIT: Interacts (via HIT-type zinc finger) with RUVBL2 in the
CC       presence of ATP or ADP; shows a stronger interaction in the presence of
CC       ADP. {ECO:0000250|UniProtKB:Q9UHR6}.
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DR   EMBL; BC109571; AAI09572.1; -; mRNA.
DR   RefSeq; NP_001035650.1; NM_001040560.2.
DR   AlphaFoldDB; Q2TBW5; -.
DR   SMR; Q2TBW5; -.
DR   STRING; 9913.ENSBTAP00000006686; -.
DR   PaxDb; Q2TBW5; -.
DR   PRIDE; Q2TBW5; -.
DR   Ensembl; ENSBTAT00000006686; ENSBTAP00000006686; ENSBTAG00000005073.
DR   GeneID; 539138; -.
DR   KEGG; bta:539138; -.
DR   CTD; 741; -.
DR   VEuPathDB; HostDB:ENSBTAG00000005073; -.
DR   VGNC; VGNC:37359; ZNHIT2.
DR   eggNOG; KOG4317; Eukaryota.
DR   GeneTree; ENSGT00390000017147; -.
DR   HOGENOM; CLU_039057_1_0_1; -.
DR   InParanoid; Q2TBW5; -.
DR   OMA; VPYCSLR; -.
DR   OrthoDB; 1599898at2759; -.
DR   TreeFam; TF324864; -.
DR   Proteomes; UP000009136; Chromosome 29.
DR   Bgee; ENSBTAG00000005073; Expressed in olfactory segment of nasal mucosa and 105 other tissues.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   InterPro; IPR007529; Znf_HIT.
DR   InterPro; IPR039646; ZNHIT2.
DR   PANTHER; PTHR15555; PTHR15555; 1.
DR   Pfam; PF04438; zf-HIT; 1.
DR   PROSITE; PS51083; ZF_HIT; 1.
PE   2: Evidence at transcript level;
KW   Acetylation; Metal-binding; Reference proteome; Zinc; Zinc-finger.
FT   CHAIN           1..399
FT                   /note="Zinc finger HIT domain-containing protein 2"
FT                   /id="PRO_0000282716"
FT   ZN_FING         7..41
FT                   /note="HIT-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00453"
FT   REGION          71..97
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          141..166
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   BINDING         7
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /ligand_label="1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00453"
FT   BINDING         10
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /ligand_label="1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00453"
FT   BINDING         22
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /ligand_label="2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00453"
FT   BINDING         25
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /ligand_label="2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00453"
FT   BINDING         30
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /ligand_label="1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00453"
FT   BINDING         34
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /ligand_label="1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00453"
FT   BINDING         38
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /ligand_label="2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00453"
FT   BINDING         41
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /ligand_label="2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00453"
FT   MOD_RES         1
FT                   /note="N-acetylmethionine"
FT                   /evidence="ECO:0000250|UniProtKB:Q9UHR6"
SQ   SEQUENCE   399 AA;  42819 MW;  CD558BA54B9BA2B4 CRC64;
     MEPAGPCGFC PTGEAQPARY TCPRCNVPYC SLRCYRAHGS CAEEFYRDQV LGELRGRSAS
     PSRLATALRR LRQQRETEDE PGDAGLRPGP APGGLSGLWE RLAPAEKVAF ERLLSRGEAG
     RLLPPWRPWW WGRGAGPRLL EELGDAPSGD AEELEPSPAR MPPEPVRDEP AAVEQVLGDL
     PGACPPAVPT RIPALASLSR GRTSPLVRFQ LPNVLFAYAH TLALYHGGDE ALLSDFCATL
     LGVSGALGAQ QVFASAEEAL QAAAHVLEAG EHPPGPLGTR GAMREAARIL LGEGPANQKS
     YTLAALGDLA QTLGRARKQA VAPEERDRLY RARKKCQFLL SWTNENEDAL TPLALDCATA
     HRAHTVAAED VAALTGELEQ LWGGPLPPAR RTLIEELPG