ID   ZNHI3_BOVIN             Reviewed;         179 AA.
AC   Q2KIH1;
DT   03-APR-2007, integrated into UniProtKB/Swiss-Prot.
DT   07-MAR-2006, sequence version 1.
DT   03-AUG-2022, entry version 81.
DE   RecName: Full=Zinc finger HIT domain-containing protein 3;
GN   Name=ZNHIT3;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Hereford; TISSUE=Testis;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (JAN-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBUNIT: Thyroid receptor interacting proteins (TRIPs) specifically
CC       interact with the ligand binding domain of the thyroid receptor (TR)
CC       (By similarity). Requires the presence of thyroid hormone for its
CC       interaction (By similarity). Interacts with NUFIP1 (By similarity).
CC       Interacts (via HIT-type zinc finger) with the RUVBL1/RUVBL2 complex in
CC       the presence of ADP (By similarity). {ECO:0000250|UniProtKB:Q15649}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q15649}. Nucleus
CC       {ECO:0000250|UniProtKB:Q15649}.
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DR   EMBL; BC112640; AAI12641.1; -; mRNA.
DR   RefSeq; NP_001039360.1; NM_001045895.1.
DR   RefSeq; XP_015314020.1; XM_015458534.1.
DR   AlphaFoldDB; Q2KIH1; -.
DR   SMR; Q2KIH1; -.
DR   STRING; 9913.ENSBTAP00000045729; -.
DR   PaxDb; Q2KIH1; -.
DR   PRIDE; Q2KIH1; -.
DR   Ensembl; ENSBTAT00000048740; ENSBTAP00000045729; ENSBTAG00000012672.
DR   GeneID; 504662; -.
DR   KEGG; bta:504662; -.
DR   CTD; 9326; -.
DR   VEuPathDB; HostDB:ENSBTAG00000012672; -.
DR   VGNC; VGNC:37360; ZNHIT3.
DR   eggNOG; KOG2857; Eukaryota.
DR   GeneTree; ENSGT00390000010822; -.
DR   HOGENOM; CLU_117355_1_0_1; -.
DR   InParanoid; Q2KIH1; -.
DR   OMA; EAQSKYK; -.
DR   OrthoDB; 1551354at2759; -.
DR   TreeFam; TF324673; -.
DR   Proteomes; UP000009136; Chromosome 19.
DR   Bgee; ENSBTAG00000012672; Expressed in oocyte and 104 other tissues.
DR   ExpressionAtlas; Q2KIH1; baseline.
DR   GO; GO:0005737; C:cytoplasm; ISS:UniProtKB.
DR   GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR   GO; GO:0070761; C:pre-snoRNP complex; IBA:GO_Central.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0000492; P:box C/D snoRNP assembly; IBA:GO_Central.
DR   GO; GO:0000463; P:maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); IBA:GO_Central.
DR   GO; GO:0048254; P:snoRNA localization; IBA:GO_Central.
DR   InterPro; IPR007529; Znf_HIT.
DR   InterPro; IPR040197; ZNHIT3.
DR   PANTHER; PTHR13483:SF11; PTHR13483:SF11; 1.
DR   Pfam; PF04438; zf-HIT; 1.
DR   PROSITE; PS51083; ZF_HIT; 1.
PE   2: Evidence at transcript level;
KW   Cytoplasm; Metal-binding; Nucleus; Phosphoprotein; Reference proteome;
KW   Zinc; Zinc-finger.
FT   CHAIN           1..179
FT                   /note="Zinc finger HIT domain-containing protein 3"
FT                   /id="PRO_0000282717"
FT   ZN_FING         11..49
FT                   /note="HIT-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00453"
FT   BINDING         11
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /ligand_label="1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00453"
FT   BINDING         14
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /ligand_label="1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00453"
FT   BINDING         22
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /ligand_label="2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00453"
FT   BINDING         25
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /ligand_label="2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00453"
FT   BINDING         30
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /ligand_label="1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00453"
FT   BINDING         34
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /ligand_label="1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00453"
FT   BINDING         38
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /ligand_label="2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00453"
FT   BINDING         49
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /ligand_label="2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00453"
FT   MOD_RES         104
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q15649"
SQ   SEQUENCE   179 AA;  19786 MW;  79BE18D2E7B33402 CRC64;
     MSSLSCGTAV CVVCLEKPKY RCPACRVPYC SLPCFRKHKA PPLQQLPVCP LRLGACCCFI
     EQCRPAAGPV EKKIRSALTA KTKKPVENEG SLDDDDSVAD FLNSDEEEDR VSLQNLKNLG
     ESAALRSLLL NPHLRQLMVD LDQADDKAKL MRACMQEPLF VEFADCCLSI VEPSQNEDP