ZNHI3_MACMU
ID ZNHI3_MACMU Reviewed; 147 AA.
AC Q6UIM1;
DT 12-APR-2005, integrated into UniProtKB/Swiss-Prot.
DT 05-JUL-2004, sequence version 1.
DT 03-AUG-2022, entry version 58.
DE RecName: Full=Zinc finger HIT domain-containing protein 3;
DE AltName: Full=Thyroid hormone receptor interactor 3;
DE AltName: Full=Thyroid receptor-interacting protein 3;
DE Short=TR-interacting protein 3;
DE Short=TRIP-3;
DE Flags: Fragment;
GN Name=ZNHIT3; Synonyms=TRIP3;
OS Macaca mulatta (Rhesus macaque).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Macaca.
OX NCBI_TaxID=9544;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=14557539; DOI=10.1073/pnas.2135499100;
RA Caceres M., Lachuer J., Zapala M.A., Redmond J.C., Kudo L., Geschwind D.H.,
RA Lockhart D.J., Preuss T.M., Barlow C.;
RT "Elevated gene expression levels distinguish human from non-human primate
RT brains.";
RL Proc. Natl. Acad. Sci. U.S.A. 100:13030-13035(2003).
CC -!- SUBUNIT: Thyroid receptor interacting proteins (TRIPs) specifically
CC interact with the ligand binding domain of the thyroid receptor (TR)
CC (By similarity). Requires the presence of thyroid hormone for its
CC interaction (By similarity). Interacts with NUFIP1 (By similarity).
CC Interacts (via HIT-type zinc finger) with the RUVBL1/RUVBL2 complex in
CC the presence of ADP (By similarity). {ECO:0000250|UniProtKB:Q15649}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q15649}. Nucleus
CC {ECO:0000250|UniProtKB:Q15649}.
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DR EMBL; AY369849; AAR11274.1; -; mRNA.
DR STRING; 9544.ENSMMUP00000010396; -.
DR PRIDE; Q6UIM1; -.
DR eggNOG; KOG2857; Eukaryota.
DR InParanoid; Q6UIM1; -.
DR Proteomes; UP000006718; Unplaced.
DR GO; GO:0005737; C:cytoplasm; ISS:UniProtKB.
DR GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR GO; GO:0070761; C:pre-snoRNP complex; IBA:GO_Central.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0000492; P:box C/D snoRNP assembly; IBA:GO_Central.
DR GO; GO:0000463; P:maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); IBA:GO_Central.
DR GO; GO:0048254; P:snoRNA localization; IBA:GO_Central.
DR InterPro; IPR007529; Znf_HIT.
DR InterPro; IPR040197; ZNHIT3.
DR PANTHER; PTHR13483:SF11; PTHR13483:SF11; 1.
DR Pfam; PF04438; zf-HIT; 1.
DR PROSITE; PS51083; ZF_HIT; 1.
PE 2: Evidence at transcript level;
KW Cytoplasm; Metal-binding; Nucleus; Phosphoprotein; Reference proteome;
KW Zinc; Zinc-finger.
FT CHAIN <1..147
FT /note="Zinc finger HIT domain-containing protein 3"
FT /id="PRO_0000173551"
FT ZN_FING 3..34
FT /note="HIT-type"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00453"
FT REGION 45..69
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 3
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /ligand_label="1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00453"
FT BINDING 6
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /ligand_label="1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00453"
FT BINDING 14
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /ligand_label="2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00453"
FT BINDING 17
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /ligand_label="2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00453"
FT BINDING 22
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /ligand_label="1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00453"
FT BINDING 26
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /ligand_label="1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00453"
FT BINDING 30
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /ligand_label="2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00453"
FT BINDING 34
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /ligand_label="2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00453"
FT MOD_RES 72
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q15649"
FT NON_TER 1
SQ SEQUENCE 147 AA; 16724 MW; 2EF1FB894AD133FA CRC64;
VVCVICLEKP KYRCPACRVP YCSVACFRKH KEQCNPEARP VEKKIRSALP TKTXKPVENK
DDDDSIADFL NSDEEEDRVS LQNLKNLGKS ATLRSLLLNP HLRQLMVNLD QGEDKAKLMR
AYMQEPLFVE FADCCLGIVE PSQNEDS
