ZNHI3_MOUSE
ID ZNHI3_MOUSE Reviewed; 151 AA.
AC Q9CQK1;
DT 12-APR-2005, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2001, sequence version 1.
DT 03-AUG-2022, entry version 115.
DE RecName: Full=Zinc finger HIT domain-containing protein 3;
DE AltName: Full=Thyroid hormone receptor interactor 3;
DE AltName: Full=Thyroid receptor-interacting protein 3;
DE Short=TR-interacting protein 3;
DE Short=TRIP-3;
GN Name=Znhit3; Synonyms=Trip3;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Embryo, Head, and Kidney;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [3]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Liver;
RX PubMed=17242355; DOI=10.1073/pnas.0609836104;
RA Villen J., Beausoleil S.A., Gerber S.A., Gygi S.P.;
RT "Large-scale phosphorylation analysis of mouse liver.";
RL Proc. Natl. Acad. Sci. U.S.A. 104:1488-1493(2007).
RN [4]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-76, AND IDENTIFICATION BY
RP MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Liver, Pancreas, and Spleen;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
RN [5]
RP TISSUE SPECIFICITY.
RX PubMed=28335020; DOI=10.1093/brain/awx040;
RA Anttonen A.K., Laari A., Kousi M., Yang Y.J., Jaeaeskelaeinen T., Somer M.,
RA Siintola E., Jakkula E., Muona M., Tegelberg S., Loennqvist T., Pihko H.,
RA Valanne L., Paetau A., Lun M.P., Haestbacka J., Kopra O., Joensuu T.,
RA Katsanis N., Lehtinen M.K., Palvimo J.J., Lehesjoki A.E.;
RT "ZNHIT3 is defective in PEHO syndrome, a severe encephalopathy with
RT cerebellar granule neuron loss.";
RL Brain 140:1267-1279(2017).
CC -!- SUBUNIT: Thyroid receptor interacting proteins (TRIPs) specifically
CC interact with the ligand binding domain of the thyroid receptor (TR)
CC (By similarity). Requires the presence of thyroid hormone for its
CC interaction (By similarity). Interacts with NUFIP1 (By similarity).
CC Interacts (via HIT-type zinc finger) with the RUVBL1/RUVBL2 complex in
CC the presence of ADP (By similarity). {ECO:0000250|UniProtKB:Q15649}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q15649}. Nucleus
CC {ECO:0000250|UniProtKB:Q15649}.
CC -!- TISSUE SPECIFICITY: Expressed in the cerebellum.
CC {ECO:0000269|PubMed:28335020}.
CC -!- DEVELOPMENTAL STAGE: Detected in proliferating fetal granule cell
CC precursors at embryonic day 16.5, in proliferating and post-mitotic
CC granule cells at postnatal days 3 and 10. Expression in cerebellar
CC Purkinje cells is strong at postnatal days 10 and 21.
CC {ECO:0000269|PubMed:28335020}.
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DR EMBL; AK014350; BAB29291.1; -; mRNA.
DR EMBL; AK002888; BAB22434.1; -; mRNA.
DR EMBL; AK003721; BAB22958.1; -; mRNA.
DR EMBL; AK004259; BAB23239.1; -; mRNA.
DR EMBL; AL645623; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR CCDS; CCDS25189.1; -.
DR RefSeq; NP_001005223.1; NM_001005223.2.
DR AlphaFoldDB; Q9CQK1; -.
DR SMR; Q9CQK1; -.
DR IntAct; Q9CQK1; 1.
DR MINT; Q9CQK1; -.
DR STRING; 10090.ENSMUSP00000099484; -.
DR iPTMnet; Q9CQK1; -.
DR PhosphoSitePlus; Q9CQK1; -.
DR EPD; Q9CQK1; -.
DR MaxQB; Q9CQK1; -.
DR PaxDb; Q9CQK1; -.
DR PeptideAtlas; Q9CQK1; -.
DR PRIDE; Q9CQK1; -.
DR ProteomicsDB; 275152; -.
DR Antibodypedia; 74086; 55 antibodies from 19 providers.
DR DNASU; 448850; -.
DR Ensembl; ENSMUST00000103195; ENSMUSP00000099484; ENSMUSG00000020526.
DR GeneID; 448850; -.
DR KEGG; mmu:448850; -.
DR UCSC; uc007kre.1; mouse.
DR CTD; 9326; -.
DR MGI; MGI:3051596; Znhit3.
DR VEuPathDB; HostDB:ENSMUSG00000020526; -.
DR eggNOG; KOG2857; Eukaryota.
DR GeneTree; ENSGT00390000010822; -.
DR HOGENOM; CLU_117355_1_0_1; -.
DR InParanoid; Q9CQK1; -.
DR OMA; EAQSKYK; -.
DR OrthoDB; 1551354at2759; -.
DR PhylomeDB; Q9CQK1; -.
DR TreeFam; TF324673; -.
DR BioGRID-ORCS; 448850; 17 hits in 76 CRISPR screens.
DR ChiTaRS; Znhit3; mouse.
DR PRO; PR:Q9CQK1; -.
DR Proteomes; UP000000589; Chromosome 11.
DR RNAct; Q9CQK1; protein.
DR Bgee; ENSMUSG00000020526; Expressed in spermatocyte and 244 other tissues.
DR Genevisible; Q9CQK1; MM.
DR GO; GO:0005737; C:cytoplasm; ISS:UniProtKB.
DR GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR GO; GO:0070761; C:pre-snoRNP complex; IBA:GO_Central.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0000492; P:box C/D snoRNP assembly; IBA:GO_Central.
DR GO; GO:0000463; P:maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); IBA:GO_Central.
DR GO; GO:0048254; P:snoRNA localization; IBA:GO_Central.
DR InterPro; IPR007529; Znf_HIT.
DR InterPro; IPR040197; ZNHIT3.
DR PANTHER; PTHR13483:SF11; PTHR13483:SF11; 1.
DR Pfam; PF04438; zf-HIT; 1.
DR PROSITE; PS51083; ZF_HIT; 1.
PE 1: Evidence at protein level;
KW Cytoplasm; Metal-binding; Nucleus; Phosphoprotein; Reference proteome;
KW Zinc; Zinc-finger.
FT CHAIN 1..151
FT /note="Zinc finger HIT domain-containing protein 3"
FT /id="PRO_0000173552"
FT ZN_FING 11..42
FT /note="HIT-type"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00453"
FT REGION 43..81
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 11
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /ligand_label="1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00453"
FT BINDING 14
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /ligand_label="1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00453"
FT BINDING 22
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /ligand_label="2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00453"
FT BINDING 25
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /ligand_label="2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00453"
FT BINDING 30
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /ligand_label="1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00453"
FT BINDING 34
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /ligand_label="1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00453"
FT BINDING 38
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /ligand_label="2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00453"
FT BINDING 42
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /ligand_label="2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00453"
FT MOD_RES 76
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:21183079"
SQ SEQUENCE 151 AA; 17068 MW; 8047204E2072EFE9 CRC64;
MASLNCRTAV CVVCLEKPKY RCPTCRVPYC SVPCFQKHKE QCSSEARPVE KRRAGPPVRS
EESKDDDSSV ADFLNSDEEE DRVSLQNLKN LGESETLRSL LLNPHLRQLM ISLDQGDNKA
KLMRACMQEP LFVEFADCCL GIVEPSQKRD S
