ID   ZNHI3_PANTR             Reviewed;         141 AA.
AC   Q6UIM2;
DT   12-APR-2005, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   03-AUG-2022, entry version 75.
DE   RecName: Full=Zinc finger HIT domain-containing protein 3;
DE   AltName: Full=Thyroid hormone receptor interactor 3;
DE   AltName: Full=Thyroid receptor-interacting protein 3;
DE            Short=TR-interacting protein 3;
DE            Short=TRIP-3;
DE   Flags: Fragment;
GN   Name=ZNHIT3; Synonyms=TRIP3;
OS   Pan troglodytes (Chimpanzee).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Pan.
OX   NCBI_TaxID=9598;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=14557539; DOI=10.1073/pnas.2135499100;
RA   Caceres M., Lachuer J., Zapala M.A., Redmond J.C., Kudo L., Geschwind D.H.,
RA   Lockhart D.J., Preuss T.M., Barlow C.;
RT   "Elevated gene expression levels distinguish human from non-human primate
RT   brains.";
RL   Proc. Natl. Acad. Sci. U.S.A. 100:13030-13035(2003).
CC   -!- SUBUNIT: Thyroid receptor interacting proteins (TRIPs) specifically
CC       interact with the ligand binding domain of the thyroid receptor (TR)
CC       (By similarity). Requires the presence of thyroid hormone for its
CC       interaction (By similarity). Interacts with NUFIP1 (By similarity).
CC       Interacts (via HIT-type zinc finger) with the RUVBL1/RUVBL2 complex in
CC       the presence of ADP (By similarity). {ECO:0000250|UniProtKB:Q15649}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q15649}. Nucleus
CC       {ECO:0000250|UniProtKB:Q15649}.
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DR   EMBL; AY369848; AAR11273.1; -; mRNA.
DR   RefSeq; NP_001181858.1; NM_001194929.1.
DR   AlphaFoldDB; Q6UIM2; -.
DR   SMR; Q6UIM2; -.
DR   STRING; 9598.ENSPTRP00000015423; -.
DR   PaxDb; Q6UIM2; -.
DR   GeneID; 450175; -.
DR   KEGG; ptr:450175; -.
DR   CTD; 9326; -.
DR   eggNOG; KOG2857; Eukaryota.
DR   InParanoid; Q6UIM2; -.
DR   OrthoDB; 1551354at2759; -.
DR   Proteomes; UP000002277; Unplaced.
DR   GO; GO:0005737; C:cytoplasm; ISS:UniProtKB.
DR   GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR   GO; GO:0070761; C:pre-snoRNP complex; IBA:GO_Central.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0000492; P:box C/D snoRNP assembly; IBA:GO_Central.
DR   GO; GO:0000463; P:maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); IBA:GO_Central.
DR   GO; GO:0048254; P:snoRNA localization; IBA:GO_Central.
DR   InterPro; IPR007529; Znf_HIT.
DR   InterPro; IPR040197; ZNHIT3.
DR   PANTHER; PTHR13483:SF11; PTHR13483:SF11; 1.
DR   Pfam; PF04438; zf-HIT; 1.
DR   PROSITE; PS51083; ZF_HIT; 1.
PE   2: Evidence at transcript level;
KW   Cytoplasm; Metal-binding; Nucleus; Phosphoprotein; Reference proteome;
KW   Zinc; Zinc-finger.
FT   CHAIN           <1..141
FT                   /note="Zinc finger HIT domain-containing protein 3"
FT                   /id="PRO_0000173553"
FT   ZN_FING         <1..28
FT                   /note="HIT-type; degenerate"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00453"
FT   BINDING         8
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00453"
FT   BINDING         11
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00453"
FT   BINDING         24
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00453"
FT   BINDING         28
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00453"
FT   MOD_RES         66
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q15649"
FT   NON_TER         1
SQ   SEQUENCE   141 AA;  16140 MW;  EEA5657E51E5CB14 CRC64;
     LEKPKYRCPA CRVPYCSVAC FRKHKEQCNP ETRPVEKKIR SALPTKTVKP VENKDDDDSI
     ADFLNSDEEE DRVSLQNLKN LGESATLRSL LLNPHLRQLM VNLDQGEDKA KLMRAYMQEP
     LFVEFADCCL GIVEPSQNEE S