ZNRD2_MOUSE
ID ZNRD2_MOUSE Reviewed; 199 AA.
AC P56873;
DT 30-MAY-2000, integrated into UniProtKB/Swiss-Prot.
DT 30-MAY-2000, sequence version 1.
DT 03-AUG-2022, entry version 128.
DE RecName: Full=Protein ZNRD2 {ECO:0000305};
DE AltName: Full=Autoantigen p27 homolog;
DE AltName: Full=Protein C184L;
DE AltName: Full=Sjoegren syndrome/scleroderma autoantigen 1 homolog;
DE AltName: Full=Zinc ribbon domain-containing protein 2;
GN Name=Znrd2; Synonyms=C184l, Sssca1 {ECO:0000312|MGI:MGI:1913482};
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], DEVELOPMENTAL STAGE, AND TISSUE SPECIFICITY.
RC STRAIN=ICR; TISSUE=Forebrain;
RX PubMed=10512749; DOI=10.1006/bbrc.1999.1462;
RA Sakuma-Takagi M., Tohyama Y., Kasama-Yoshida H., Sakagami H., Kondo H.,
RA Kurihara T.;
RT "Novel related cDNAs (C184L, C184M, and C184S) from developing mouse brain
RT encoding two apparently unrelated proteins.";
RL Biochem. Biophys. Res. Commun. 263:737-742(1999).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=FVB/N; TISSUE=Liver;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Brain, Brown adipose tissue, Heart, Kidney, Liver, Lung, Spleen, and
RC Testis;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- FUNCTION: Might play a role in mitosis. Could be a centromere-
CC associated protein. Antigenic molecule. May induce anti-centromere
CC antibodies. {ECO:0000250|UniProtKB:O60232}.
CC -!- TISSUE SPECIFICITY: Expressed in the early postnatal brain.
CC {ECO:0000269|PubMed:10512749}.
CC -!- DEVELOPMENTAL STAGE: Expressed in forebrain at 16 dpc.
CC {ECO:0000269|PubMed:10512749}.
CC -!- MISCELLANEOUS: Two ORFs are contained in the Sssca1 gene, but only this
CC protein is efficiently translated and expressed.
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DR EMBL; AB012727; BAA87048.1; -; mRNA.
DR EMBL; BC021593; AAH21593.1; -; mRNA.
DR CCDS; CCDS29479.1; -.
DR RefSeq; NP_065237.3; NM_020491.5.
DR AlphaFoldDB; P56873; -.
DR SMR; P56873; -.
DR BioGRID; 207948; 2.
DR IntAct; P56873; 4.
DR MINT; P56873; -.
DR STRING; 10090.ENSMUSP00000025885; -.
DR iPTMnet; P56873; -.
DR PhosphoSitePlus; P56873; -.
DR EPD; P56873; -.
DR PaxDb; P56873; -.
DR PeptideAtlas; P56873; -.
DR PRIDE; P56873; -.
DR ProteomicsDB; 257416; -.
DR DNASU; 56390; -.
DR Ensembl; ENSMUST00000025885; ENSMUSP00000025885; ENSMUSG00000079478.
DR Ensembl; ENSMUST00000160852; ENSMUSP00000125570; ENSMUSG00000118125.
DR GeneID; 56390; -.
DR KEGG; mmu:56390; -.
DR UCSC; uc008gfd.2; mouse.
DR CTD; 10534; -.
DR MGI; MGI:1913482; Znrd2.
DR VEuPathDB; HostDB:ENSMUSG00000079478; -.
DR VEuPathDB; HostDB:ENSMUSG00000118125; -.
DR eggNOG; KOG4537; Eukaryota.
DR GeneTree; ENSGT00390000013169; -.
DR HOGENOM; CLU_058702_0_0_1; -.
DR InParanoid; P56873; -.
DR OMA; VACQELN; -.
DR OrthoDB; 1602560at2759; -.
DR PhylomeDB; P56873; -.
DR TreeFam; TF320182; -.
DR BioGRID-ORCS; 56390; 2 hits in 72 CRISPR screens.
DR PRO; PR:P56873; -.
DR Proteomes; UP000000589; Chromosome 19.
DR RNAct; P56873; protein.
DR Bgee; ENSMUSG00000079478; Expressed in epiblast (generic) and 71 other tissues.
DR ExpressionAtlas; P56873; baseline and differential.
DR Genevisible; P56873; MM.
DR InterPro; IPR009563; SSSCA1.
DR Pfam; PF06677; Auto_anti-p27; 1.
PE 1: Evidence at protein level;
KW Acetylation; Phosphoprotein; Reference proteome.
FT INIT_MET 1
FT /note="Removed"
FT /evidence="ECO:0000250|UniProtKB:O60232"
FT CHAIN 2..199
FT /note="Protein ZNRD2"
FT /id="PRO_0000072202"
FT REGION 93..148
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 93..110
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 2
FT /note="N-acetylalanine"
FT /evidence="ECO:0000250|UniProtKB:O60232"
FT MOD_RES 94
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:O60232"
SQ SEQUENCE 199 AA; 21336 MW; 13A5222048009E00 CRC64;
MALNGADVDD FTWEPPTEAE TKVLQARRER QDRISRLMGD YLLRGYRMLG DTCADCGTIL
LQDKQRKIYC VACQELDSDV DKDNPALNAQ AALSQAREHQ LASSTEPASS SRPPSQPPVP
RPEHCEGAAA GLKAAQAPPL PAAPPNTDAV ASTQTALLQK LTWASVELGS STSLETSIQL
CGLIRACAEA LGSLKQLDH
