ZNRF1_PLAF7
ID ZNRF1_PLAF7 Reviewed; 1103 AA.
AC Q6LFN2;
DT 16-DEC-2008, integrated into UniProtKB/Swiss-Prot.
DT 05-JUL-2004, sequence version 1.
DT 25-MAY-2022, entry version 103.
DE RecName: Full=RING finger protein PFF0165c;
GN ORFNames=PFF0165c;
OS Plasmodium falciparum (isolate 3D7).
OC Eukaryota; Sar; Alveolata; Apicomplexa; Aconoidasida; Haemosporida;
OC Plasmodiidae; Plasmodium; Plasmodium (Laverania).
OX NCBI_TaxID=36329;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=3D7;
RX PubMed=12368864; DOI=10.1038/nature01097;
RA Gardner M.J., Hall N., Fung E., White O., Berriman M., Hyman R.W.,
RA Carlton J.M., Pain A., Nelson K.E., Bowman S., Paulsen I.T., James K.D.,
RA Eisen J.A., Rutherford K.M., Salzberg S.L., Craig A., Kyes S., Chan M.-S.,
RA Nene V., Shallom S.J., Suh B., Peterson J., Angiuoli S., Pertea M.,
RA Allen J., Selengut J., Haft D., Mather M.W., Vaidya A.B., Martin D.M.A.,
RA Fairlamb A.H., Fraunholz M.J., Roos D.S., Ralph S.A., McFadden G.I.,
RA Cummings L.M., Subramanian G.M., Mungall C., Venter J.C., Carucci D.J.,
RA Hoffman S.L., Newbold C., Davis R.W., Fraser C.M., Barrell B.G.;
RT "Genome sequence of the human malaria parasite Plasmodium falciparum.";
RL Nature 419:498-511(2002).
RN [2] {ECO:0000312|EMBL:CAG25204.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=3D7;
RX PubMed=12368867; DOI=10.1038/nature01095;
RA Hall N., Pain A., Berriman M., Churcher C.M., Harris B., Harris D.,
RA Mungall K.L., Bowman S., Atkin R., Baker S., Barron A., Brooks K.,
RA Buckee C.O., Burrows C., Cherevach I., Chillingworth C., Chillingworth T.,
RA Christodoulou Z., Clark L., Clark R., Corton C., Cronin A., Davies R.M.,
RA Davis P., Dear P., Dearden F., Doggett J., Feltwell T., Goble A.,
RA Goodhead I., Gwilliam R., Hamlin N., Hance Z., Harper D., Hauser H.,
RA Hornsby T., Holroyd S., Horrocks P., Humphray S., Jagels K., James K.D.,
RA Johnson D., Kerhornou A., Knights A., Konfortov B., Kyes S., Larke N.,
RA Lawson D., Lennard N., Line A., Maddison M., Mclean J., Mooney P.,
RA Moule S., Murphy L., Oliver K., Ormond D., Price C., Quail M.A.,
RA Rabbinowitsch E., Rajandream M.A., Rutter S., Rutherford K.M., Sanders M.,
RA Simmonds M., Seeger K., Sharp S., Smith R., Squares R., Squares S.,
RA Stevens K., Taylor K., Tivey A., Unwin L., Whitehead S., Woodward J.R.,
RA Sulston J.E., Craig A., Newbold C., Barrell B.G.;
RT "Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13.";
RL Nature 419:527-531(2002).
RN [3] {ECO:0000305}
RP SYNTHESIS OF 481-505 AND 845-871, DEVELOPMENTAL STAGE, AND POSSIBLE
RP CANDIDATE MALARIA EPITOPE.
RX PubMed=17653272; DOI=10.1371/journal.pone.0000645;
RA Villard V., Agak G.W., Frank G., Jafarshad A., Servis C., Nebie I.,
RA Sirima S.B., Felger I., Arevalo-Herrera M., Herrera S., Heitz F.,
RA Baecker V., Druilhe P., Kajava A.V., Corradin G.;
RT "Rapid identification of malaria vaccine candidates based on alpha-helical
RT coiled coil protein motif.";
RL PLoS ONE 2:E645-E645(2007).
CC -!- DEVELOPMENTAL STAGE: Expressed during the asexual cell-cycle on the
CC cell surface of the host erythrocytes. {ECO:0000269|PubMed:17653272}.
CC -!- BIOTECHNOLOGY: Possible candidate for an effective malaria vaccine as
CC determined by epitope response in sera. {ECO:0000269|PubMed:17653272}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AL844505; CAG25204.1; -; Genomic_DNA.
DR RefSeq; XP_966024.1; XM_960931.1.
DR AlphaFoldDB; Q6LFN2; -.
DR SMR; Q6LFN2; -.
DR BioGRID; 1210459; 4.
DR IntAct; Q6LFN2; 4.
DR STRING; 5833.PFF0165c; -.
DR PRIDE; Q6LFN2; -.
DR EnsemblProtists; CAG25204; CAG25204; PF3D7_0603400.
DR GeneID; 3885786; -.
DR KEGG; pfa:PF3D7_0603400; -.
DR VEuPathDB; PlasmoDB:PF3D7_0603400; -.
DR HOGENOM; CLU_325573_0_0_1; -.
DR InParanoid; Q6LFN2; -.
DR OMA; RNINVVW; -.
DR PhylomeDB; Q6LFN2; -.
DR Proteomes; UP000001450; Chromosome 6.
DR GO; GO:0020036; C:Maurer's cleft; IDA:GeneDB.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0061630; F:ubiquitin protein ligase activity; IBA:GO_Central.
DR GO; GO:0043161; P:proteasome-mediated ubiquitin-dependent protein catabolic process; IBA:GO_Central.
DR Gene3D; 3.30.40.10; -; 1.
DR InterPro; IPR001841; Znf_RING.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR InterPro; IPR017907; Znf_RING_CS.
DR SMART; SM00184; RING; 1.
DR PROSITE; PS00518; ZF_RING_1; 1.
DR PROSITE; PS50089; ZF_RING_2; 1.
PE 1: Evidence at protein level;
KW Coiled coil; Merozoite; Metal-binding; Reference proteome; Zinc;
KW Zinc-finger.
FT CHAIN 1..1103
FT /note="RING finger protein PFF0165c"
FT /id="PRO_0000356835"
FT ZN_FING 1050..1089
FT /note="RING-type"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00175"
FT REGION 178..210
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 271..301
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 544..601
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 173..212
FT /evidence="ECO:0000255"
FT COILED 304..330
FT /evidence="ECO:0000255"
FT COILED 478..518
FT /evidence="ECO:0000255"
FT COILED 650..791
FT /evidence="ECO:0000255"
FT COILED 819..932
FT /evidence="ECO:0000255"
FT COILED 993..1030
FT /evidence="ECO:0000255"
FT COMPBIAS 184..208
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 277..296
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 549..601
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1103 AA; 132471 MW; 42FA8DC9152F4475 CRC64;
MSNKKRSKNE NDESTSLPLE NSELLIEYIH NLKSCLNVYR REIQEKNKYI SIIKNDLSFH
ECILTNVNVV WSVFNNDLLN LLCNNEQKEE GEEIIKQRNI GDEINEYNNL TKLQNDENIK
NNNMIKEDLE DDANQNILMK SPYYNIENFL QVFLKYINKK KKKVKVKVKD EGKKEKIEDK
KYEQDDEEEN EEEEEEEEEE EGEEENKEDE EFFKTFVSFN LYHNNNEKNI SYDKNLVKQE
NDNKDEARGN DNMCGNYDIH NERGEMLDKG KSYSGDEKIN TSDNAKSCSG DEKVITSDNG
KSYDYVKNES EEQEEKENML NNKKRSLECN PNEAKKICFS LEEKIGTVQS VKLKEYNELS
KENIEKNKHD DNNICNYLSH NEGENVIERE DKLFNKLNNK NYRNEEEKKK NQINFDYLKK
KIKNNQDVFE ETIQKCFLIN LKKTLNLINK IMYLKNVEFR KYNLDYIRKI NYEKCFYYKN
YIDIKKKISE LQKDNESLKI QVDRLEKKKA TLIYKLNNDN IRKHILDNNI KDYQNGIDNS
KVSYFDEGEN PYNRNNKNYR TDNKNSDDNN NNNNYYYNNY NSDDNYNSED NEYNNGNYRF
RNNYKKDSLN EDDVKKNPLK VCHKINSDSN IFVNFENIIT KQNIIHSEPF RNLLKESNEL
YITLKEKEKE NIILKNEILK MENKKDEEYE HLLNNTIEDK KELTRSIKEL EINMMTCNME
KDKISNKVNT LEYEINVLKN IDKNQTMQLQ QKENDILKMK LYIEKLKLSE KNLKDKIILL
ENEKDKMLSG IHIKDNSFNE ESKSEEGKIQ LRDIQNDNDE KYDDEKKRFK ELFIENQKLK
EELNKKRNVE EELHSLRKNY NIINEEIEEI TKEFEKKQEQ VDEMILQIKN KELELLDKFN
NKMNKAYVEE KLKELKNTYE EKMKHINNIY KKHDDFVNIY LNLFFQARKN AILSDSQREE
QMNLFIKLKD KYDIIFQKKI ELTDILKNVY DCNKKLIGHC QDLEKENSTL QNKLSNEIKN
SKMLSKNLSK NSDDHLLIEE NNELRRRLIC SVCMENFRNY IIIKCGHIYC NNCIFNNLKT
RNRKCPQCKV PFDKKDLQKI FLD
