ZNRF2_PLAF7
ID ZNRF2_PLAF7 Reviewed; 1272 AA.
AC Q8I480;
DT 03-NOV-2009, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2003, sequence version 1.
DT 25-MAY-2022, entry version 121.
DE RecName: Full=RING finger protein PFE0100w;
GN ORFNames=PFE0100w;
OS Plasmodium falciparum (isolate 3D7).
OC Eukaryota; Sar; Alveolata; Apicomplexa; Aconoidasida; Haemosporida;
OC Plasmodiidae; Plasmodium; Plasmodium (Laverania).
OX NCBI_TaxID=36329;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=3D7;
RX PubMed=12368864; DOI=10.1038/nature01097;
RA Gardner M.J., Hall N., Fung E., White O., Berriman M., Hyman R.W.,
RA Carlton J.M., Pain A., Nelson K.E., Bowman S., Paulsen I.T., James K.D.,
RA Eisen J.A., Rutherford K.M., Salzberg S.L., Craig A., Kyes S., Chan M.-S.,
RA Nene V., Shallom S.J., Suh B., Peterson J., Angiuoli S., Pertea M.,
RA Allen J., Selengut J., Haft D., Mather M.W., Vaidya A.B., Martin D.M.A.,
RA Fairlamb A.H., Fraunholz M.J., Roos D.S., Ralph S.A., McFadden G.I.,
RA Cummings L.M., Subramanian G.M., Mungall C., Venter J.C., Carucci D.J.,
RA Hoffman S.L., Newbold C., Davis R.W., Fraser C.M., Barrell B.G.;
RT "Genome sequence of the human malaria parasite Plasmodium falciparum.";
RL Nature 419:498-511(2002).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=3D7;
RX PubMed=12368867; DOI=10.1038/nature01095;
RA Hall N., Pain A., Berriman M., Churcher C.M., Harris B., Harris D.,
RA Mungall K.L., Bowman S., Atkin R., Baker S., Barron A., Brooks K.,
RA Buckee C.O., Burrows C., Cherevach I., Chillingworth C., Chillingworth T.,
RA Christodoulou Z., Clark L., Clark R., Corton C., Cronin A., Davies R.M.,
RA Davis P., Dear P., Dearden F., Doggett J., Feltwell T., Goble A.,
RA Goodhead I., Gwilliam R., Hamlin N., Hance Z., Harper D., Hauser H.,
RA Hornsby T., Holroyd S., Horrocks P., Humphray S., Jagels K., James K.D.,
RA Johnson D., Kerhornou A., Knights A., Konfortov B., Kyes S., Larke N.,
RA Lawson D., Lennard N., Line A., Maddison M., Mclean J., Mooney P.,
RA Moule S., Murphy L., Oliver K., Ormond D., Price C., Quail M.A.,
RA Rabbinowitsch E., Rajandream M.A., Rutter S., Rutherford K.M., Sanders M.,
RA Simmonds M., Seeger K., Sharp S., Smith R., Squares R., Squares S.,
RA Stevens K., Taylor K., Tivey A., Unwin L., Whitehead S., Woodward J.R.,
RA Sulston J.E., Craig A., Newbold C., Barrell B.G.;
RT "Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13.";
RL Nature 419:527-531(2002).
RN [3] {ECO:0000305}
RP SYNTHESIS OF 193-221, AND POSSIBLE CANDIDATE MALARIA EPITOPE.
RX PubMed=17653272; DOI=10.1371/journal.pone.0000645;
RA Villard V., Agak G.W., Frank G., Jafarshad A., Servis C., Nebie I.,
RA Sirima S.B., Felger I., Arevalo-Herrera M., Herrera S., Heitz F.,
RA Baecker V., Druilhe P., Kajava A.V., Corradin G.;
RT "Rapid identification of malaria vaccine candidates based on alpha-helical
RT coiled coil protein motif.";
RL PLoS ONE 2:E645-E645(2007).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000255}; Single-pass membrane
CC protein {ECO:0000255}.
CC -!- BIOTECHNOLOGY: Possible candidate for an effective malaria vaccine as
CC determined by epitope response in sera. {ECO:0000269|PubMed:17653272}.
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DR EMBL; AL844504; CAD51386.1; -; Genomic_DNA.
DR RefSeq; XP_001351579.1; XM_001351543.1.
DR AlphaFoldDB; Q8I480; -.
DR BioGRID; 1208178; 1.
DR IntAct; Q8I480; 1.
DR STRING; 5833.PFE0100w; -.
DR PRIDE; Q8I480; -.
DR EnsemblProtists; CAD51386; CAD51386; PF3D7_0502000.
DR GeneID; 812859; -.
DR KEGG; pfa:PF3D7_0502000; -.
DR VEuPathDB; PlasmoDB:PF3D7_0502000; -.
DR HOGENOM; CLU_283940_0_0_1; -.
DR InParanoid; Q8I480; -.
DR OMA; FNDEHTM; -.
DR PhylomeDB; Q8I480; -.
DR Proteomes; UP000001450; Chromosome 5.
DR GO; GO:0005768; C:endosome; IBA:GO_Central.
DR GO; GO:0030897; C:HOPS complex; IBA:GO_Central.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0016020; C:membrane; ISS:GeneDB.
DR GO; GO:0030674; F:protein-macromolecule adaptor activity; IBA:GO_Central.
DR GO; GO:0008270; F:zinc ion binding; ISS:GeneDB.
DR GO; GO:0007032; P:endosome organization; IBA:GO_Central.
DR GO; GO:0006886; P:intracellular protein transport; ISS:GeneDB.
DR GO; GO:0048284; P:organelle fusion; IBA:GO_Central.
DR GO; GO:0007033; P:vacuole organization; IBA:GO_Central.
DR GO; GO:0006904; P:vesicle docking involved in exocytosis; IBA:GO_Central.
DR GO; GO:0016192; P:vesicle-mediated transport; ISS:GeneDB.
DR Gene3D; 3.30.40.10; -; 1.
DR InterPro; IPR000547; Clathrin_H-chain/VPS_repeat.
DR InterPro; IPR016528; VPS11.
DR InterPro; IPR024763; VPS11_C.
DR InterPro; IPR001841; Znf_RING.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR PANTHER; PTHR23323:SF24; PTHR23323:SF24; 1.
DR Pfam; PF12451; VPS11_C; 1.
DR PROSITE; PS50236; CHCR; 1.
DR PROSITE; PS50089; ZF_RING_2; 1.
PE 1: Evidence at protein level;
KW Coiled coil; Membrane; Merozoite; Metal-binding; Reference proteome;
KW Transmembrane; Transmembrane helix; Zinc; Zinc-finger.
FT CHAIN 1..1272
FT /note="RING finger protein PFE0100w"
FT /id="PRO_0000388770"
FT TRANSMEM 771..791
FT /note="Helical"
FT /evidence="ECO:0000255"
FT REPEAT 608..752
FT /note="CHCR"
FT ZN_FING 1189..1224
FT /note="RING-type; atypical"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00175"
FT REGION 216..260
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 842..862
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 908..970
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 1146..1182
FT /evidence="ECO:0000255"
FT COMPBIAS 216..233
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 234..260
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1272 AA; 151643 MW; 2940F2E5298C058B CRC64;
MFNFRNLPLF DKDNSKDTDD IKNFINSYEG IYFSSSNKFI NVFLDKILII DPSSLNVITI
NTDLYVVDFL FNEKNKNLIV LGKGKNSLIC SVYNIRECNF TLLKKIQLSK NINNIKKTLI
AKCNEYIITL ENKKITFYFL NKDYSINQSE LIEDGKELIE NIYLSKNHIL LVIKNSYVYI
YQLDIKNSHI SYTLIDSFNL NLSYLRESIN NKKKHINKIN DVSNNDPKKD NNEKNTSSNN
ITHNNYNDIS NNNNNNNNIN GVKDHINNNT LENNDEPILS IYNEDLNVLY ICQNMYNVLF
VLNLNNLSFE FILLENKIIN LFSCKFYLIL LKEVNKKFFL HIYIIYEDMK LLVSTLLLNE
PISNVIFFNN LFCLLIEEEI SKPEIKVDKF YFYEQLKLKL HSKLDGDALK ILKRDHVTNN
INICKQEEKK YKLKNEQKDV EIYNKNNTVD STNNTIYNSE VNHYKYITND FFLNEDVNTD
IKKELYNLNH TKDNINHDTL KKQTNQNDIT MSLSKDEKNN DTNKFFNENM FTLNKFFKNC
RNQIKIILKE RNINEIINMF KKKKLYQWLI KYANLNKNYQ IININFIHKI YADFLFEKEQ
YENAIYEYIQ TINYLETSYV IHKYLNLDLY EYLTIYLEKL HVYHHFNDEH TMMLLSCYKK
QCKKKKMISF IKKNKDKINL NKTYKFLLNA GYYNIVLNLS KKYKDHFTYV SILIEKYENY
EKSLKYIFKL DVENICILLF KYGYKFIKYY PQLTIYLLKK IIKKYNINLT IFIPLFLDNI
DFLFMFIVKF LDKNVNINKI NHIQEKQKHH YSNMYHDSDE LNSVTKQKNK INSFLLYEKD
NNQNHNGIPS DSHNLSDDNN SQESTTAVNL INKTNLQLDI FNGEYDYILF VTVIQILLQK
YKKSMQEENQ TNNQSSKQTN NQSSKQTNKQ SINQSNNQSI NQTNNQSIKQ TNIQTNKQKG
NSTTNKIINK DETNEQNNIL TFNIDKLIQN NKDKNINFLS VLLLSIYNYN KGLIYTSTQM
NKYDISLLFS IHKFINNTKG KINKINMDEH KPNEQTMQIN SSYKILNRNF QKVIYNICIN
HLKLNGSLSY NYIFYYLSML NDEKYLIKFI KKIRQDMNLS IFNLIQILKK YNKSYSCIQN
MVVAYMNDMN KNINDKCIEI EKDKKELEKI KKKQLKKKYN FYLIDNAYCS ICKEILSVPM
IHFLCKHSYH SYCLKDNNVC ILCHNKDKEK KLLKEKAINS IQNFDEFFKY LQGSTDKFSY
ISNYLSYGIT PK
