ZNT1_HUMAN
ID ZNT1_HUMAN Reviewed; 507 AA.
AC Q9Y6M5; Q0VAK9; Q9BZF6;
DT 30-MAY-2000, integrated into UniProtKB/Swiss-Prot.
DT 07-JUL-2009, sequence version 3.
DT 03-AUG-2022, entry version 175.
DE RecName: Full=Zinc transporter 1;
DE Short=ZnT-1;
DE AltName: Full=Solute carrier family 30 member 1;
GN Name=SLC30A1; Synonyms=ZNT1;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA Nanji M.S., Coronado V.A., Cox D.W.;
RT "Cloning and characterization of human zinc transporter 1 (ZNT1).";
RL Submitted (NOV-2000) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA].
RA Goshima N., Kawamura Y., Fukumoto A., Miura A., Honma R., Satoh R.,
RA Wakamatsu A., Yamamoto J., Kimura K., Nishikawa T., Andoh T., Iida Y.,
RA Ishikawa K., Ito E., Kagawa N., Kaminaga C., Kanehori K., Kawakami B.,
RA Kenmochi K., Kimura R., Kobayashi M., Kuroita T., Kuwayama H., Maruyama Y.,
RA Matsuo K., Minami K., Mitsubori M., Mori M., Morishita R., Murase A.,
RA Nishikawa A., Nishikawa S., Okamoto T., Sakagami N., Sakamoto Y.,
RA Sasaki Y., Seki T., Sono S., Sugiyama A., Sumiya T., Takayama T.,
RA Takayama Y., Takeda H., Togashi T., Yahata K., Yamada H., Yanagisawa Y.,
RA Endo Y., Imamoto F., Kisu Y., Tanaka S., Isogai T., Imai J., Watanabe S.,
RA Nomura N.;
RT "Human Protein Factory: an infrastructure to convert the human
RT transcriptome into the in vitro-expressed human proteome of versatile
RT utility.";
RL Submitted (JUL-2008) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [5]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 411-507.
RA Inoue H., Oka Y.;
RT "Assignment of the human zinc transporter gene 1 (ZnT1) to chromosomes 1.";
RL Submitted (FEB-1998) to the EMBL/GenBank/DDBJ databases.
RN [6]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Cervix carcinoma;
RX PubMed=17081983; DOI=10.1016/j.cell.2006.09.026;
RA Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M.;
RT "Global, in vivo, and site-specific phosphorylation dynamics in signaling
RT networks.";
RL Cell 127:635-648(2006).
RN [7]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-506, AND IDENTIFICATION BY
RP MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Cervix carcinoma;
RX PubMed=18669648; DOI=10.1073/pnas.0805139105;
RA Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,
RA Elledge S.J., Gygi S.P.;
RT "A quantitative atlas of mitotic phosphorylation.";
RL Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008).
RN [8]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=21406692; DOI=10.1126/scisignal.2001570;
RA Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T.,
RA Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.;
RT "System-wide temporal characterization of the proteome and phosphoproteome
RT of human embryonic stem cell differentiation.";
RL Sci. Signal. 4:RS3-RS3(2011).
RN [9]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Cervix carcinoma, and Erythroleukemia;
RX PubMed=23186163; DOI=10.1021/pr300630k;
RA Zhou H., Di Palma S., Preisinger C., Peng M., Polat A.N., Heck A.J.,
RA Mohammed S.;
RT "Toward a comprehensive characterization of a human cancer cell
RT phosphoproteome.";
RL J. Proteome Res. 12:260-271(2013).
CC -!- FUNCTION: May be involved in zinc transport out of the cell.
CC -!- SUBUNIT: Multimer. {ECO:0000305}.
CC -!- INTERACTION:
CC Q9Y6M5; Q9BRI3: SLC30A2; NbExp=4; IntAct=EBI-10982148, EBI-8644112;
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the cation diffusion facilitator (CDF)
CC transporter (TC 2.A.4) family. SLC30A subfamily. {ECO:0000305}.
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DR EMBL; AF323590; AAG53405.1; -; Genomic_DNA.
DR EMBL; AB451467; BAG70281.1; -; mRNA.
DR EMBL; CH471100; EAW93412.1; -; Genomic_DNA.
DR EMBL; BC121015; AAI21016.1; -; mRNA.
DR EMBL; BC121016; AAI21017.1; -; mRNA.
DR EMBL; AF048701; AAD29840.1; -; Genomic_DNA.
DR CCDS; CCDS1499.1; -.
DR RefSeq; NP_067017.2; NM_021194.2.
DR AlphaFoldDB; Q9Y6M5; -.
DR SASBDB; Q9Y6M5; -.
DR SMR; Q9Y6M5; -.
DR BioGRID; 113560; 111.
DR IntAct; Q9Y6M5; 38.
DR MINT; Q9Y6M5; -.
DR STRING; 9606.ENSP00000355968; -.
DR DrugBank; DB14533; Zinc chloride.
DR DrugBank; DB14548; Zinc sulfate, unspecified form.
DR TCDB; 2.A.4.2.6; the cation diffusion facilitator (cdf) family.
DR GlyGen; Q9Y6M5; 1 site.
DR iPTMnet; Q9Y6M5; -.
DR PhosphoSitePlus; Q9Y6M5; -.
DR SwissPalm; Q9Y6M5; -.
DR BioMuta; SLC30A1; -.
DR DMDM; 251757423; -.
DR EPD; Q9Y6M5; -.
DR jPOST; Q9Y6M5; -.
DR MassIVE; Q9Y6M5; -.
DR MaxQB; Q9Y6M5; -.
DR PaxDb; Q9Y6M5; -.
DR PeptideAtlas; Q9Y6M5; -.
DR PRIDE; Q9Y6M5; -.
DR ProteomicsDB; 86733; -.
DR Antibodypedia; 20709; 234 antibodies from 26 providers.
DR DNASU; 7779; -.
DR Ensembl; ENST00000367001.5; ENSP00000355968.4; ENSG00000170385.10.
DR GeneID; 7779; -.
DR KEGG; hsa:7779; -.
DR MANE-Select; ENST00000367001.5; ENSP00000355968.4; NM_021194.3; NP_067017.2.
DR UCSC; uc001hio.2; human.
DR CTD; 7779; -.
DR DisGeNET; 7779; -.
DR GeneCards; SLC30A1; -.
DR HGNC; HGNC:11012; SLC30A1.
DR HPA; ENSG00000170385; Tissue enhanced (liver).
DR MIM; 609521; gene.
DR neXtProt; NX_Q9Y6M5; -.
DR OpenTargets; ENSG00000170385; -.
DR PharmGKB; PA35882; -.
DR VEuPathDB; HostDB:ENSG00000170385; -.
DR eggNOG; KOG1483; Eukaryota.
DR GeneTree; ENSGT00940000156484; -.
DR HOGENOM; CLU_013430_4_3_1; -.
DR InParanoid; Q9Y6M5; -.
DR OMA; HADMGMN; -.
DR OrthoDB; 820567at2759; -.
DR PhylomeDB; Q9Y6M5; -.
DR TreeFam; TF313924; -.
DR PathwayCommons; Q9Y6M5; -.
DR Reactome; R-HSA-435368; Zinc efflux and compartmentalization by the SLC30 family.
DR SignaLink; Q9Y6M5; -.
DR BioGRID-ORCS; 7779; 26 hits in 1083 CRISPR screens.
DR GeneWiki; SLC30A1; -.
DR GenomeRNAi; 7779; -.
DR Pharos; Q9Y6M5; Tbio.
DR PRO; PR:Q9Y6M5; -.
DR Proteomes; UP000005640; Chromosome 1.
DR RNAct; Q9Y6M5; protein.
DR Bgee; ENSG00000170385; Expressed in jejunal mucosa and 204 other tissues.
DR Genevisible; Q9Y6M5; HS.
DR GO; GO:0005737; C:cytoplasm; IDA:UniProtKB.
DR GO; GO:0005783; C:endoplasmic reticulum; IDA:UniProtKB.
DR GO; GO:0005794; C:Golgi apparatus; IDA:UniProtKB.
DR GO; GO:0016021; C:integral component of membrane; IBA:GO_Central.
DR GO; GO:0099061; C:integral component of postsynaptic density membrane; IEA:Ensembl.
DR GO; GO:0031965; C:nuclear membrane; IDA:UniProtKB.
DR GO; GO:0005886; C:plasma membrane; IDA:BHF-UCL.
DR GO; GO:0098685; C:Schaffer collateral - CA1 synapse; IEA:Ensembl.
DR GO; GO:0030315; C:T-tubule; ISS:BHF-UCL.
DR GO; GO:0019855; F:calcium channel inhibitor activity; ISS:BHF-UCL.
DR GO; GO:0005385; F:zinc ion transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0070574; P:cadmium ion transmembrane transport; ISS:BHF-UCL.
DR GO; GO:0070509; P:calcium ion import; IEA:Ensembl.
DR GO; GO:0006874; P:cellular calcium ion homeostasis; ISS:BHF-UCL.
DR GO; GO:0006882; P:cellular zinc ion homeostasis; ISS:BHF-UCL.
DR GO; GO:0071585; P:detoxification of cadmium ion; IEA:Ensembl.
DR GO; GO:0010312; P:detoxification of zinc ion; IBA:GO_Central.
DR GO; GO:0001701; P:in utero embryonic development; IEA:Ensembl.
DR GO; GO:0090281; P:negative regulation of calcium ion import; ISS:BHF-UCL.
DR GO; GO:0046929; P:negative regulation of neurotransmitter secretion; ISS:BHF-UCL.
DR GO; GO:0071584; P:negative regulation of zinc ion transmembrane import; ISS:BHF-UCL.
DR GO; GO:0071577; P:zinc ion transmembrane transport; IBA:GO_Central.
DR GO; GO:0006829; P:zinc ion transport; ISS:BHF-UCL.
DR Gene3D; 1.20.1510.10; -; 1.
DR InterPro; IPR002524; Cation_efflux.
DR InterPro; IPR036837; Cation_efflux_CTD_sf.
DR InterPro; IPR027469; Cation_efflux_TMD_sf.
DR Pfam; PF01545; Cation_efflux; 1.
DR SUPFAM; SSF160240; SSF160240; 1.
DR SUPFAM; SSF161111; SSF161111; 1.
DR TIGRFAMs; TIGR01297; CDF; 1.
PE 1: Evidence at protein level;
KW Cell membrane; Glycoprotein; Ion transport; Membrane; Phosphoprotein;
KW Reference proteome; Repeat; Transmembrane; Transmembrane helix; Transport;
KW Zinc; Zinc transport.
FT CHAIN 1..507
FT /note="Zinc transporter 1"
FT /id="PRO_0000206090"
FT TOPO_DOM 1..10
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 11..31
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 32..35
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 36..56
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 57..78
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 79..99
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 100..113
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 114..134
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 135..248
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 249..269
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 270..308
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 309..329
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 330..507
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT REGION 142..217
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 146..158
FT /note="6 X 2 AA approximate repeats of H-G"
FT COMPBIAS 183..204
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 506
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:18669648"
FT CARBOHYD 299
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CONFLICT 386
FT /note="A -> V (in Ref. 1; AAG53405)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 507 AA; 55300 MW; 2FC5B67F033AE457 CRC64;
MGCWGRNRGR LLCMLALTFM FMVLEVVVSR VTSSLAMLSD SFHMLSDVLA LVVALVAERF
ARRTHATQKN TFGWIRAEVM GALVNAIFLT GLCFAILLEA IERFIEPHEM QQPLVVLGVG
VAGLLVNVLG LCLFHHHSGF SQDSGHGHSH GGHGHGHGLP KGPRVKSTRP GSSDINVAPG
EQGPDQEETN TLVANTSNSN GLKLDPADPE NPRSGDTVEV QVNGNLVREP DHMELEEDRA
GQLNMRGVFL HVLGDALGSV IVVVNALVFY FSWKGCSEGD FCVNPCFPDP CKAFVEIINS
THASVYEAGP CWVLYLDPTL CVVMVCILLY TTYPLLKESA LILLQTVPKQ IDIRNLIKEL
RNVEGVEEVH ELHVWQLAGS RIIATAHIKC EDPTSYMEVA KTIKDVFHNH GIHATTIQPE
FASVGSKSSV VPCELACRTQ CALKQCCGTL PQAPSGKDAE KTPAVSISCL ELSNNLEKKP
RRTKAENIPA VVIEIKNMPN KQPESSL
