ID   ZNT1_MACFA              Reviewed;         505 AA.
AC   Q4R6K2; Q4R8P6;
DT   22-NOV-2005, integrated into UniProtKB/Swiss-Prot.
DT   19-JUL-2005, sequence version 1.
DT   03-AUG-2022, entry version 72.
DE   RecName: Full=Zinc transporter 1;
DE            Short=ZnT-1;
DE   AltName: Full=Solute carrier family 30 member 1;
GN   Name=SLC30A1; Synonyms=ZNT1; ORFNames=QtsA-11880, QtsA-17815;
OS   Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC   Cercopithecidae; Cercopithecinae; Macaca.
OX   NCBI_TaxID=9541;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Testis;
RG   International consortium for macaque cDNA sequencing and analysis;
RT   "DNA sequences of macaque genes expressed in brain or testis and its
RT   evolutionary implications.";
RL   Submitted (JUN-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: May be involved in zinc transport out of the cell.
CC   -!- SUBUNIT: Multimer. {ECO:0000305}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the cation diffusion facilitator (CDF)
CC       transporter (TC 2.A.4) family. SLC30A subfamily. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=BAE00525.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; AB168404; BAE00525.1; ALT_INIT; mRNA.
DR   EMBL; AB169181; BAE01273.1; -; mRNA.
DR   RefSeq; NP_001270881.1; NM_001283952.1.
DR   AlphaFoldDB; Q4R6K2; -.
DR   SMR; Q4R6K2; -.
DR   STRING; 9541.XP_005540816.1; -.
DR   GeneID; 101926515; -.
DR   CTD; 7779; -.
DR   eggNOG; KOG1483; Eukaryota.
DR   OrthoDB; 820567at2759; -.
DR   Proteomes; UP000233100; Unplaced.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0008324; F:cation transmembrane transporter activity; IEA:InterPro.
DR   GO; GO:0006829; P:zinc ion transport; IEA:UniProtKB-KW.
DR   Gene3D; 1.20.1510.10; -; 1.
DR   InterPro; IPR002524; Cation_efflux.
DR   InterPro; IPR036837; Cation_efflux_CTD_sf.
DR   InterPro; IPR027469; Cation_efflux_TMD_sf.
DR   Pfam; PF01545; Cation_efflux; 1.
DR   SUPFAM; SSF160240; SSF160240; 1.
DR   SUPFAM; SSF161111; SSF161111; 1.
DR   TIGRFAMs; TIGR01297; CDF; 1.
PE   2: Evidence at transcript level;
KW   Cell membrane; Ion transport; Membrane; Phosphoprotein; Reference proteome;
KW   Repeat; Transmembrane; Transmembrane helix; Transport; Zinc;
KW   Zinc transport.
FT   CHAIN           1..505
FT                   /note="Zinc transporter 1"
FT                   /id="PRO_0000206091"
FT   TOPO_DOM        1..10
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        11..31
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        32..35
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        36..56
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        57..80
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        81..101
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        102..113
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        114..134
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        135..246
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        247..267
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        268..306
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        307..327
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        328..505
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   REGION          142..215
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        181..201
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         504
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q9Y6M5"
FT   CONFLICT        386
FT                   /note="I -> M (in Ref. 1; BAE00525)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   505 AA;  55231 MW;  CF8D6D2302E267DC CRC64;
     MGCWGRNRGR LLCMLALTFM FMVLEVVVSR VTSSLAMLSD SFHMLSDVLA LVVALVAERF
     ARRTHATQKN TFGWIRAEVM GALVNAIFLT GLCFAILLEA IERFVEPHEM QQPLVVLGVG
     VAGLLVNVLG LCLFHHHSGF SQDSGHSHSH GSHGHGLPKG PRVKSSRPGS NDINVAPGEQ
     GPDQEETNTL VANTSNSNGL KLDPADPEKP RSGDTVEVQV NGNLIREPDH VELEEDRAGQ
     LNMRGVFLHV LGDALGSVIV VVNALVFYFS WKGCSEGDFC VNPCFPDPCK AFVEIINSTH
     ASVYEAGPCW VLYLDPTLCV VMVCILLYTT YPLLKESALI LLQTVPKQID IRNLIKELRN
     VEGVEEVHEL HVWQLAGSRI IATAHIKCED PTSYMEVAKT IKDVFHNHGI HATTIQPEFA
     SVGSKSSVVP CELACRTQCA LKQCCGTLPQ AHSGKDAEKT PTVSISCLEL SNNLEKKPRR
     TKAENIPAVV IEIKNMPNKQ PESSL