ID   ZNT1_RAT                Reviewed;         507 AA.
AC   Q62720;
DT   30-MAY-2000, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   03-AUG-2022, entry version 154.
DE   RecName: Full=Zinc transporter 1;
DE            Short=ZnT-1;
DE   AltName: Full=Solute carrier family 30 member 1;
GN   Name=Slc30a1; Synonyms=Znt1;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Kidney;
RX   PubMed=7882967; DOI=10.1002/j.1460-2075.1995.tb07042.x;
RA   Palmiter R.D., Findley S.D.;
RT   "Cloning and functional characterization of a mammalian zinc transporter
RT   that confers resistance to zinc.";
RL   EMBO J. 14:639-649(1995).
RN   [2]
RP   INDUCTION BY ZINC.
RC   TISSUE=Intestine;
RX   PubMed=9560190; DOI=10.1073/pnas.95.9.4841;
RA   McMahon R.J., Cousins R.J.;
RT   "Regulation of the zinc transporter ZnT-1 by dietary zinc.";
RL   Proc. Natl. Acad. Sci. U.S.A. 95:4841-4846(1998).
CC   -!- FUNCTION: May be involved in zinc transport out of the cell.
CC   -!- SUBUNIT: Multimer. {ECO:0000305}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}. Note=Localized on the basolateral surface of the
CC       enterocytes.
CC   -!- TISSUE SPECIFICITY: Widely expressed. The protein is detected in
CC       duodenum and jejunum but not in ileum and colon.
CC   -!- INDUCTION: Slightly by zinc in the intestine, but not the liver.
CC       {ECO:0000269|PubMed:9560190}.
CC   -!- SIMILARITY: Belongs to the cation diffusion facilitator (CDF)
CC       transporter (TC 2.A.4) family. SLC30A subfamily. {ECO:0000305}.
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DR   EMBL; U17133; AAA79234.1; -; mRNA.
DR   PIR; S54303; S54303.
DR   RefSeq; NP_074044.1; NM_022853.2.
DR   AlphaFoldDB; Q62720; -.
DR   SMR; Q62720; -.
DR   IntAct; Q62720; 2.
DR   STRING; 10116.ENSRNOP00000006340; -.
DR   TCDB; 2.A.4.2.3; the cation diffusion facilitator (cdf) family.
DR   GlyGen; Q62720; 1 site.
DR   iPTMnet; Q62720; -.
DR   PhosphoSitePlus; Q62720; -.
DR   SwissPalm; Q62720; -.
DR   PaxDb; Q62720; -.
DR   PRIDE; Q62720; -.
DR   Ensembl; ENSRNOT00000006340; ENSRNOP00000006340; ENSRNOG00000004749.
DR   GeneID; 58976; -.
DR   KEGG; rno:58976; -.
DR   CTD; 7779; -.
DR   RGD; 61918; Slc30a1.
DR   eggNOG; KOG1483; Eukaryota.
DR   GeneTree; ENSGT00940000156484; -.
DR   HOGENOM; CLU_013430_4_3_1; -.
DR   InParanoid; Q62720; -.
DR   OMA; HADMGMN; -.
DR   OrthoDB; 820567at2759; -.
DR   PhylomeDB; Q62720; -.
DR   TreeFam; TF313924; -.
DR   Reactome; R-RNO-435368; Zinc efflux and compartmentalization by the SLC30 family.
DR   PRO; PR:Q62720; -.
DR   Proteomes; UP000002494; Chromosome 13.
DR   Bgee; ENSRNOG00000004749; Expressed in liver and 18 other tissues.
DR   Genevisible; Q62720; RN.
DR   GO; GO:0005737; C:cytoplasm; ISO:RGD.
DR   GO; GO:0005783; C:endoplasmic reticulum; ISO:RGD.
DR   GO; GO:0005794; C:Golgi apparatus; ISO:RGD.
DR   GO; GO:0016021; C:integral component of membrane; IDA:RGD.
DR   GO; GO:0099061; C:integral component of postsynaptic density membrane; IDA:SynGO.
DR   GO; GO:0031965; C:nuclear membrane; ISO:RGD.
DR   GO; GO:0005886; C:plasma membrane; IDA:MGI.
DR   GO; GO:0098685; C:Schaffer collateral - CA1 synapse; IDA:SynGO.
DR   GO; GO:0030315; C:T-tubule; IDA:BHF-UCL.
DR   GO; GO:0019855; F:calcium channel inhibitor activity; IMP:BHF-UCL.
DR   GO; GO:0005385; F:zinc ion transmembrane transporter activity; IDA:MGI.
DR   GO; GO:0070574; P:cadmium ion transmembrane transport; IMP:BHF-UCL.
DR   GO; GO:0070509; P:calcium ion import; IMP:BHF-UCL.
DR   GO; GO:0006874; P:cellular calcium ion homeostasis; ISO:RGD.
DR   GO; GO:0006882; P:cellular zinc ion homeostasis; ISO:RGD.
DR   GO; GO:0071585; P:detoxification of cadmium ion; IMP:BHF-UCL.
DR   GO; GO:0010312; P:detoxification of zinc ion; IBA:GO_Central.
DR   GO; GO:0001701; P:in utero embryonic development; ISO:RGD.
DR   GO; GO:0090281; P:negative regulation of calcium ion import; ISO:RGD.
DR   GO; GO:0046929; P:negative regulation of neurotransmitter secretion; IMP:BHF-UCL.
DR   GO; GO:0071584; P:negative regulation of zinc ion transmembrane import; ISO:RGD.
DR   GO; GO:0071577; P:zinc ion transmembrane transport; IBA:GO_Central.
DR   GO; GO:0006829; P:zinc ion transport; IDA:MGI.
DR   Gene3D; 1.20.1510.10; -; 1.
DR   InterPro; IPR002524; Cation_efflux.
DR   InterPro; IPR036837; Cation_efflux_CTD_sf.
DR   InterPro; IPR027469; Cation_efflux_TMD_sf.
DR   Pfam; PF01545; Cation_efflux; 1.
DR   SUPFAM; SSF160240; SSF160240; 1.
DR   SUPFAM; SSF161111; SSF161111; 1.
DR   TIGRFAMs; TIGR01297; CDF; 1.
PE   2: Evidence at transcript level;
KW   Cell membrane; Glycoprotein; Ion transport; Membrane; Phosphoprotein;
KW   Reference proteome; Repeat; Transmembrane; Transmembrane helix; Transport;
KW   Zinc; Zinc transport.
FT   CHAIN           1..507
FT                   /note="Zinc transporter 1"
FT                   /id="PRO_0000206093"
FT   TOPO_DOM        1..10
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        11..31
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        32..35
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        36..56
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        57..78
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        79..99
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        100..113
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        114..134
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        135..247
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        248..268
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        269..307
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        308..328
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        329..507
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   REGION          140..218
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          145..156
FT                   /note="6 X 2 AA approximate repeats of H-G"
FT   COMPBIAS        185..203
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         506
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q9Y6M5"
FT   CARBOHYD        298
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   507 AA;  55143 MW;  9F9770017C2455FC CRC64;
     MGCWGRNRGR LLCMLLLTFM FMVLEVVVSR VTASLAMLSD SFHMLSDVLA LVVALVAERF
     ARRTHATQKN TFGWIRAEVM GALVNAIFLT GLCFAILLEA VERFIEPHEM QQPLVVLSVG
     VAGLLVNVLG LCLFHHHSGE GQGAGHGHSH GHGHGHLAKG ARKAGRAGGE AGAPPGRAPD
     QEPDQEETNT LVANTSNSNG LKADQAEPEK LRSDDPVDVQ VNGNLIQESD SLESEDNRAG
     QLNMRGVFLH VLGDALGSVI VVVNALVFYF SWKGCTEDDF CVNPCFPDPC KSSVELMNST
     QAPMHEAGPC WVLYLDPTLC IIMVCILLYT TYPLLKESAL ILLQTVPKQI DIKHLVKELR
     DVEGVEEVHE LHVWQLAGSR IIATAHIKCE DPASYMQVAK TIKDVFHNHG IHATTIQPEF
     ASVGSKSSVV PCELACRTQC ALKQCCGTRP QVHSGKEAEK APTVSISCLE LSENLEKKPR
     RTKAEGSVPA VVIEIKNVPN KQPESSL