ZNT2_MOUSE
ID ZNT2_MOUSE Reviewed; 371 AA.
AC Q2HJ10;
DT 22-FEB-2012, integrated into UniProtKB/Swiss-Prot.
DT 21-MAR-2006, sequence version 1.
DT 03-AUG-2022, entry version 111.
DE RecName: Full=Zinc transporter 2;
DE Short=ZnT-2;
DE AltName: Full=Solute carrier family 30 member 2;
GN Name=Slc30a2; Synonyms=Znt2;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- INTERACTION:
CC Q2HJ10; Q3UVU3: Slc30a10; NbExp=2; IntAct=EBI-13945312, EBI-13945374;
CC -!- SUBCELLULAR LOCATION: Vacuole membrane; Multi-pass membrane protein.
CC -!- SIMILARITY: Belongs to the cation diffusion facilitator (CDF)
CC transporter (TC 2.A.4) family. SLC30A subfamily. {ECO:0000305}.
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DR EMBL; AL669982; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC113751; AAI13752.1; -; mRNA.
DR CCDS; CCDS38915.1; -.
DR RefSeq; NP_001034766.1; NM_001039677.2.
DR AlphaFoldDB; Q2HJ10; -.
DR SMR; Q2HJ10; -.
DR IntAct; Q2HJ10; 2.
DR STRING; 10090.ENSMUSP00000101500; -.
DR iPTMnet; Q2HJ10; -.
DR PhosphoSitePlus; Q2HJ10; -.
DR PaxDb; Q2HJ10; -.
DR PRIDE; Q2HJ10; -.
DR ProteomicsDB; 275044; -.
DR Antibodypedia; 15992; 51 antibodies from 19 providers.
DR Ensembl; ENSMUST00000105874; ENSMUSP00000101500; ENSMUSG00000028836.
DR GeneID; 230810; -.
DR KEGG; mmu:230810; -.
DR UCSC; uc008veu.2; mouse.
DR CTD; 7780; -.
DR MGI; MGI:106637; Slc30a2.
DR VEuPathDB; HostDB:ENSMUSG00000028836; -.
DR eggNOG; KOG1482; Eukaryota.
DR GeneTree; ENSGT00940000156072; -.
DR InParanoid; Q2HJ10; -.
DR OMA; GHEKMLH; -.
DR OrthoDB; 973492at2759; -.
DR PhylomeDB; Q2HJ10; -.
DR TreeFam; TF313382; -.
DR BioGRID-ORCS; 230810; 3 hits in 72 CRISPR screens.
DR ChiTaRS; Slc30a2; mouse.
DR PRO; PR:Q2HJ10; -.
DR Proteomes; UP000000589; Chromosome 4.
DR RNAct; Q2HJ10; protein.
DR Bgee; ENSMUSG00000028836; Expressed in ectoplacental cone and 85 other tissues.
DR ExpressionAtlas; Q2HJ10; baseline and differential.
DR Genevisible; Q2HJ10; MM.
DR GO; GO:0005737; C:cytoplasm; ISO:MGI.
DR GO; GO:0031410; C:cytoplasmic vesicle; ISO:MGI.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0043231; C:intracellular membrane-bounded organelle; ISO:MGI.
DR GO; GO:0005770; C:late endosome; ISO:MGI.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0005774; C:vacuolar membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0042802; F:identical protein binding; ISO:MGI.
DR GO; GO:0005385; F:zinc ion transmembrane transporter activity; ISO:MGI.
DR GO; GO:0061090; P:positive regulation of sequestering of zinc ion; ISO:MGI.
DR GO; GO:0061088; P:regulation of sequestering of zinc ion; IBA:GO_Central.
DR GO; GO:0010043; P:response to zinc ion; IBA:GO_Central.
DR GO; GO:0071577; P:zinc ion transmembrane transport; IBA:GO_Central.
DR GO; GO:0006829; P:zinc ion transport; ISO:MGI.
DR Gene3D; 1.20.1510.10; -; 1.
DR InterPro; IPR002524; Cation_efflux.
DR InterPro; IPR036837; Cation_efflux_CTD_sf.
DR InterPro; IPR027469; Cation_efflux_TMD_sf.
DR Pfam; PF01545; Cation_efflux; 1.
DR SUPFAM; SSF160240; SSF160240; 1.
DR SUPFAM; SSF161111; SSF161111; 1.
DR TIGRFAMs; TIGR01297; CDF; 1.
PE 1: Evidence at protein level;
KW Ion transport; Membrane; Reference proteome; Transmembrane;
KW Transmembrane helix; Transport; Vacuole; Zinc; Zinc transport.
FT CHAIN 1..371
FT /note="Zinc transporter 2"
FT /id="PRO_0000415850"
FT TOPO_DOM 1..69
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 70..90
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 91..99
FT /note="Vacuolar"
FT /evidence="ECO:0000255"
FT TRANSMEM 100..120
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 121..136
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 137..157
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 158..172
FT /note="Vacuolar"
FT /evidence="ECO:0000255"
FT TRANSMEM 173..193
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 194..219
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 220..240
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 241..248
FT /note="Vacuolar"
FT /evidence="ECO:0000255"
FT TRANSMEM 249..269
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 270..303
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 304..324
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 325..371
FT /note="Vacuolar"
FT /evidence="ECO:0000255"
SQ SEQUENCE 371 AA; 40639 MW; 03C0B3D72539A189 CRC64;
MQTMDKQNLL ESTRGARSFL GSLWKSEASR IPPVDLPAVE LAVQSNHYCH AQKDSGSHPD
PEKQRARRKL YVASAICLVF MIGEIIGGYL AQSLAIMTDA AHLLTDFASM LISLFALWVS
SRPATKTMNF GWHRAEILGA LLSVLSIWVV TGVLVYLAVQ RLISGDYEIK GDTMLITSGC
AVAVNLIMGL ALHQSGHGHS HGNSRDDSSQ QQNPSVRAAF IHVIGDLLQS VGVLVAAYII
YFKPEYKYVD PICTFLFSIL VLGTTLTILR DVILVLMEGT PKGVDFTTVK NLLLSVDGVE
ALHSLHIWAL TVAQPVLSVH IAIAQNADAQ AVLKVARDRL QGKFNFHTMT IQIEKYSEDM
KNCQACQGPL E
