ID   ZNT2_RAT                Reviewed;         359 AA.
AC   Q62941;
DT   30-MAY-2000, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   25-MAY-2022, entry version 139.
DE   RecName: Full=Zinc transporter 2;
DE            Short=ZnT-2;
DE   AltName: Full=Solute carrier family 30 member 2;
GN   Name=Slc30a2; Synonyms=Znt2;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   STRAIN=Sprague-Dawley; TISSUE=Kidney;
RX   PubMed=8617223; DOI=10.1002/j.1460-2075.1996.tb00527.x;
RA   Palmiter R.D., Cole T.B., Findley S.D.;
RT   "ZnT-2, a mammalian protein that confers resistance to zinc by facilitating
RT   vesicular sequestration.";
RL   EMBO J. 15:1784-1791(1996).
CC   -!- FUNCTION: Involved in accumulation of zinc in endosomal/lysosomal
CC       vesicles.
CC   -!- SUBCELLULAR LOCATION: Endosome membrane {ECO:0000305}; Multi-pass
CC       membrane protein {ECO:0000305}.
CC   -!- TISSUE SPECIFICITY: Intestine, kidney, seminal vesicles and testis.
CC   -!- SIMILARITY: Belongs to the cation diffusion facilitator (CDF)
CC       transporter (TC 2.A.4) family. SLC30A subfamily. {ECO:0000305}.
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DR   EMBL; U50927; AAB02775.1; -; mRNA.
DR   PIR; S70632; S70632.
DR   RefSeq; NP_037022.1; NM_012890.2.
DR   AlphaFoldDB; Q62941; -.
DR   SMR; Q62941; -.
DR   STRING; 10116.ENSRNOP00000067545; -.
DR   TCDB; 2.A.4.3.1; the cation diffusion facilitator (cdf) family.
DR   PaxDb; Q62941; -.
DR   GeneID; 25362; -.
DR   KEGG; rno:25362; -.
DR   UCSC; RGD:3707; rat.
DR   CTD; 7780; -.
DR   RGD; 3707; Slc30a2.
DR   eggNOG; KOG1482; Eukaryota.
DR   InParanoid; Q62941; -.
DR   PRO; PR:Q62941; -.
DR   Proteomes; UP000002494; Unplaced.
DR   GO; GO:0005737; C:cytoplasm; ISO:RGD.
DR   GO; GO:0031410; C:cytoplasmic vesicle; IDA:RGD.
DR   GO; GO:0010008; C:endosome membrane; TAS:Reactome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005770; C:late endosome; ISO:RGD.
DR   GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR   GO; GO:0042802; F:identical protein binding; ISO:RGD.
DR   GO; GO:0005385; F:zinc ion transmembrane transporter activity; IDA:RGD.
DR   GO; GO:0061090; P:positive regulation of sequestering of zinc ion; ISO:RGD.
DR   GO; GO:0061088; P:regulation of sequestering of zinc ion; IBA:GO_Central.
DR   GO; GO:0010043; P:response to zinc ion; IBA:GO_Central.
DR   GO; GO:0071577; P:zinc ion transmembrane transport; IBA:GO_Central.
DR   GO; GO:0006829; P:zinc ion transport; IDA:RGD.
DR   Gene3D; 1.20.1510.10; -; 1.
DR   InterPro; IPR002524; Cation_efflux.
DR   InterPro; IPR036837; Cation_efflux_CTD_sf.
DR   InterPro; IPR027469; Cation_efflux_TMD_sf.
DR   Pfam; PF01545; Cation_efflux; 1.
DR   SUPFAM; SSF160240; SSF160240; 1.
DR   SUPFAM; SSF161111; SSF161111; 1.
DR   TIGRFAMs; TIGR01297; CDF; 1.
PE   2: Evidence at transcript level;
KW   Endosome; Ion transport; Membrane; Reference proteome; Repeat;
KW   Transmembrane; Transmembrane helix; Transport; Zinc; Zinc transport.
FT   CHAIN           1..359
FT                   /note="Zinc transporter 2"
FT                   /id="PRO_0000206095"
FT   TOPO_DOM        1..56
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        57..77
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        78..86
FT                   /note="Vacuolar"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        87..107
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        108..123
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        124..144
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        145..159
FT                   /note="Vacuolar"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        160..180
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        181..207
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        208..228
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        229..236
FT                   /note="Vacuolar"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        237..257
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        258..291
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        292..312
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        313..359
FT                   /note="Vacuolar"
FT                   /evidence="ECO:0000255"
FT   REGION          183..192
FT                   /note="5 X 2 AA approximate repeats of H-G"
SQ   SEQUENCE   359 AA;  39277 MW;  256A307021D1D197 CRC64;
     MASRSFFGAL WKSEASRIPP VNLPSVELAV QSNHYCHAQK DSGSHPNSEK QRARRKLYVA
     SAICLVFMIG EIIGGYLAQS LAIMTDAAHL LTDFASMLIS LFSLWVSSRP ATKTMNFGWQ
     RAEILGALLS VLSIWVVTGV LVYLAVQRLI SGDYEIKGDT MLITSGCAVA VNIIMGLALH
     QSGHGHSHGH SHEDSSQQQQ NPSVRAAFIH VVGDLLQSVG VLVAAYIIYF KPEYKYVDPI
     CTFLFSILVL GTTLTILRDV ILVLMEGTPK GVDFTTVKNL LLSVDGVEAL HSLHIWALTV
     AQPVLSVHIA IAQNVDAQAV LKVARDRLQG KFNFHTMTIQ IESYSEDMKS CQECQGPSE