ZNT3_BOVIN
ID ZNT3_BOVIN Reviewed; 388 AA.
AC Q08E25;
DT 03-APR-2007, integrated into UniProtKB/Swiss-Prot.
DT 31-OCT-2006, sequence version 1.
DT 03-AUG-2022, entry version 103.
DE RecName: Full=Zinc transporter 3 {ECO:0000250|UniProtKB:Q99726};
DE Short=ZnT-3 {ECO:0000250|UniProtKB:Q99726};
DE AltName: Full=Solute carrier family 30 member 3 {ECO:0000250|UniProtKB:Q99726};
GN Name=SLC30A3 {ECO:0000250|UniProtKB:Q99726};
OS Bos taurus (Bovine).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Bovinae; Bos.
OX NCBI_TaxID=9913;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Hereford; TISSUE=Thalamus;
RG NIH - Mammalian Gene Collection (MGC) project;
RL Submitted (SEP-2006) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Zinc ion transporter mediating the import of zinc from
CC cytoplasm into synaptic vesicles and participating to cellular zinc ion
CC homeostasis in the brain. {ECO:0000250|UniProtKB:Q99726}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=Zn(2+)(in) = Zn(2+)(out); Xref=Rhea:RHEA:29351,
CC ChEBI:CHEBI:29105; Evidence={ECO:0000250|UniProtKB:Q99726};
CC -!- SUBUNIT: Homodimer. Homodimerization could regulate efficiency of zinc
CC transport. {ECO:0000250|UniProtKB:Q99726}.
CC -!- SUBCELLULAR LOCATION: Cytoplasmic vesicle, secretory vesicle, synaptic
CC vesicle membrane {ECO:0000250|UniProtKB:Q99726}; Multi-pass membrane
CC protein {ECO:0000255}. Synapse, synaptosome
CC {ECO:0000250|UniProtKB:P97441}. Late endosome membrane
CC {ECO:0000250|UniProtKB:Q99726}; Multi-pass membrane protein
CC {ECO:0000255}. Lysosome membrane {ECO:0000250|UniProtKB:Q99726}; Multi-
CC pass membrane protein {ECO:0000255}.
CC -!- SIMILARITY: Belongs to the cation diffusion facilitator (CDF)
CC transporter (TC 2.A.4) family. SLC30A subfamily. {ECO:0000305}.
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DR EMBL; BC123455; AAI23456.1; -; mRNA.
DR RefSeq; NP_001070311.1; NM_001076843.1.
DR AlphaFoldDB; Q08E25; -.
DR SMR; Q08E25; -.
DR STRING; 9913.ENSBTAP00000015117; -.
DR PaxDb; Q08E25; -.
DR PRIDE; Q08E25; -.
DR Ensembl; ENSBTAT00000015117; ENSBTAP00000015117; ENSBTAG00000011381.
DR GeneID; 512803; -.
DR KEGG; bta:512803; -.
DR CTD; 7781; -.
DR VEuPathDB; HostDB:ENSBTAG00000011381; -.
DR VGNC; VGNC:34808; SLC30A3.
DR eggNOG; KOG1482; Eukaryota.
DR GeneTree; ENSGT00940000161480; -.
DR HOGENOM; CLU_013430_0_1_1; -.
DR InParanoid; Q08E25; -.
DR OMA; RTWGWAR; -.
DR OrthoDB; 973492at2759; -.
DR TreeFam; TF313382; -.
DR Proteomes; UP000009136; Chromosome 11.
DR Bgee; ENSBTAG00000011381; Expressed in caput epididymis and 71 other tissues.
DR GO; GO:0070161; C:anchoring junction; IEA:UniProtKB-KW.
DR GO; GO:0098978; C:glutamatergic synapse; IEA:Ensembl.
DR GO; GO:0097457; C:hippocampal mossy fiber; IEA:Ensembl.
DR GO; GO:0098686; C:hippocampal mossy fiber to CA3 synapse; IEA:Ensembl.
DR GO; GO:0030285; C:integral component of synaptic vesicle membrane; IEA:Ensembl.
DR GO; GO:0031902; C:late endosome membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005765; C:lysosomal membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0043005; C:neuron projection; ISS:UniProtKB.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0008021; C:synaptic vesicle; ISS:UniProtKB.
DR GO; GO:0005385; F:zinc ion transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0051050; P:positive regulation of transport; IEA:Ensembl.
DR GO; GO:0061088; P:regulation of sequestering of zinc ion; IBA:GO_Central.
DR GO; GO:0010043; P:response to zinc ion; IBA:GO_Central.
DR GO; GO:0099180; P:zinc ion import into synaptic vesicle; IEA:Ensembl.
DR GO; GO:0071577; P:zinc ion transmembrane transport; ISS:UniProtKB.
DR Gene3D; 1.20.1510.10; -; 1.
DR InterPro; IPR002524; Cation_efflux.
DR InterPro; IPR036837; Cation_efflux_CTD_sf.
DR InterPro; IPR027469; Cation_efflux_TMD_sf.
DR Pfam; PF01545; Cation_efflux; 1.
DR SUPFAM; SSF160240; SSF160240; 1.
DR SUPFAM; SSF161111; SSF161111; 1.
DR TIGRFAMs; TIGR01297; CDF; 1.
PE 2: Evidence at transcript level;
KW Cytoplasmic vesicle; Endosome; Ion transport; Lysosome; Membrane;
KW Reference proteome; Synapse; Synaptosome; Transmembrane;
KW Transmembrane helix; Transport; Zinc; Zinc transport.
FT CHAIN 1..388
FT /note="Zinc transporter 3"
FT /id="PRO_0000283049"
FT TOPO_DOM 1..75
FT /note="Cytoplasmic"
FT /evidence="ECO:0000305"
FT TRANSMEM 76..96
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 97..105
FT /note="Lumenal"
FT /evidence="ECO:0000305"
FT TRANSMEM 106..126
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 127..145
FT /note="Cytoplasmic"
FT /evidence="ECO:0000305"
FT TRANSMEM 146..166
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 167..177
FT /note="Lumenal"
FT /evidence="ECO:0000305"
FT TRANSMEM 178..198
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 199..235
FT /note="Cytoplasmic"
FT /evidence="ECO:0000305"
FT TRANSMEM 236..256
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 257..264
FT /note="Lumenal"
FT /evidence="ECO:0000305"
FT TRANSMEM 265..285
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 286..388
FT /note="Cytoplasmic"
FT /evidence="ECO:0000305"
FT REGION 1..30
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 35..54
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 388 AA; 41820 MW; 853C3C7770EC0720 CRC64;
MEPSPTTGGS ETTRLVGPRD RGGAGGGLRL KSLFTEAPEP LPEEPKPVEM SFHHCHRDPL
PQPGLTPERM QAQRQLCTAC AVCCVFMAGE VVGGYLAHSL AIMTDAAHLL ADVGSMMGSL
FSLWLSTRPA TRTMTFGWHR SETLGALASV VSLWMVTGIL LYLAFIRLLH SDYHIEGGAM
LLTASIAVCA NLLMAFVLHQ AGPPHSHGSR GAEYAPLEEG SGEPLPLGNT SVRAAFVHVL
GDLLQSLGVL IASILIYFKP QYKAADPIST FLFSICALGS TAPTLRDVLR VLMEGTPRSV
SFEPVRDTLL SVPGVRAIHE LHLWSLTFTH YVASAHLAID STADPEAVLA EATSRLHSRF
GFSSCTLQVE QYQPEMAQCL RCQEPPQA
