ZNT4_BOVIN
ID ZNT4_BOVIN Reviewed; 429 AA.
AC Q9TTF3;
DT 30-MAY-2000, integrated into UniProtKB/Swiss-Prot.
DT 03-AUG-2022, sequence version 2.
DT 03-AUG-2022, entry version 114.
DE RecName: Full=Zinc transporter 4 {ECO:0000250|UniProtKB:O14863};
DE Short=ZnT-4;
DE AltName: Full=Solute carrier family 30 member 4 {ECO:0000250|UniProtKB:O14863};
GN Name=SLC30A4 {ECO:0000250|UniProtKB:O14863};
OS Bos taurus (Bovine).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Bovinae; Bos.
OX NCBI_TaxID=9913;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Hereford;
RX PubMed=19393038; DOI=10.1186/gb-2009-10-4-r42;
RA Zimin A.V., Delcher A.L., Florea L., Kelley D.R., Schatz M.C., Puiu D.,
RA Hanrahan F., Pertea G., Van Tassell C.P., Sonstegard T.S., Marcais G.,
RA Roberts M., Subramanian P., Yorke J.A., Salzberg S.L.;
RT "A whole-genome assembly of the domestic cow, Bos taurus.";
RL Genome Biol. 10:R42.01-R42.10(2009).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 240-289.
RX PubMed=10612253; DOI=10.1046/j.1365-2052.1999.00498-15.x;
RA Tammen I., Warren W.C., Raadsma H.W.;
RT "Physical and linkage mapping of the bovine zinc transporter 4 (ZNT4) gene
RT to chromosome 10.";
RL Anim. Genet. 30:474-475(1999).
CC -!- FUNCTION: Zinc ion transporter mediating zinc import from cytoplasm
CC potentially into the endocytic compartment (By similarity). Controls
CC zinc deposition in milk (By similarity). {ECO:0000250|UniProtKB:O14863,
CC ECO:0000250|UniProtKB:O35149}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=Zn(2+)(in) = Zn(2+)(out); Xref=Rhea:RHEA:29351,
CC ChEBI:CHEBI:29105; Evidence={ECO:0000250|UniProtKB:O14863};
CC -!- SUBUNIT: Homodimerization could regulate efficiency for zinc transport.
CC {ECO:0000250|UniProtKB:O14863}.
CC -!- SUBCELLULAR LOCATION: Endosome membrane {ECO:0000250|UniProtKB:O55174};
CC Multi-pass membrane protein {ECO:0000255}. Late endosome membrane
CC {ECO:0000250|UniProtKB:O14863}; Multi-pass membrane protein
CC {ECO:0000255}. Lysosome membrane {ECO:0000250|UniProtKB:O14863}; Multi-
CC pass membrane protein {ECO:0000255}. Note=Enriched in vesicles within
CC the basal region of epithelial cells. {ECO:0000250|UniProtKB:O55174}.
CC -!- SIMILARITY: Belongs to the cation diffusion facilitator (CDF)
CC transporter (TC 2.A.4) family. SLC30A subfamily. {ECO:0000305}.
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DR EMBL; NKLS02000010; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AF103904; AAF16866.1; -; Genomic_DNA.
DR AlphaFoldDB; Q9TTF3; -.
DR SMR; Q9TTF3; -.
DR PaxDb; Q9TTF3; -.
DR eggNOG; KOG1482; Eukaryota.
DR HOGENOM; CLU_013430_0_1_1; -.
DR Proteomes; UP000009136; Unplaced.
DR GO; GO:0010008; C:endosome membrane; ISS:UniProtKB.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005770; C:late endosome; ISS:UniProtKB.
DR GO; GO:0031902; C:late endosome membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005765; C:lysosomal membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0071577; P:zinc ion transmembrane transport; ISS:UniProtKB.
PE 3: Inferred from homology;
KW Endosome; Ion transport; Lysosome; Membrane; Reference proteome;
KW Transmembrane; Transmembrane helix; Transport; Zinc; Zinc transport.
FT CHAIN 1..429
FT /note="Zinc transporter 4"
FT /id="PRO_0000206098"
FT TOPO_DOM 1..113
FT /note="Cytoplasmic"
FT /evidence="ECO:0000305"
FT TRANSMEM 114..134
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 135..143
FT /note="Lumenal"
FT /evidence="ECO:0000305"
FT TRANSMEM 144..164
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 165..178
FT /note="Cytoplasmic"
FT /evidence="ECO:0000305"
FT TRANSMEM 179..199
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 200..216
FT /note="Lumenal"
FT /evidence="ECO:0000305"
FT TRANSMEM 217..237
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 238..274
FT /note="Cytoplasmic"
FT /evidence="ECO:0000305"
FT TRANSMEM 275..295
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 296..310
FT /note="Lumenal"
FT /evidence="ECO:0000305"
FT TRANSMEM 311..331
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 332..429
FT /note="Cytoplasmic"
FT /evidence="ECO:0000305"
FT REGION 1..26
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 240..264
FT /note="Zinc binding"
FT /evidence="ECO:0000250|UniProtKB:O55174"
FT COMPBIAS 8..24
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 429 AA; 47389 MW; 71F51E3D176F5F50 CRC64;
MAGSGAWKRL KSMLRKDDAP LFLNDTSAFD FSDEVGDEGL SRFNKLRVVV ADDGSEAPER
PANGAHSALQ ADDDSLLDQD LPLTNSQLSL KADPCDNCSK QRELLKQRKV KTRLTIAAVL
YLLFMIGELV GGYIANSLAI MTDALHMLTD LSAIILTLLA LWLSSKSPTK RFTFGFHRLE
VLSAMISVLL VYILMGFLLY EAVQRTIHMK YEINGDIMLI TAAIGVAVNV IMGFLLNQSG
HHHAHSHSLP SNSPTTGPRC GHNQGQDSLA VRAAFVHALG DLVQSVGVLI AAYIIRFKPE
YRIADPICTY VFSLLVAFTT FRIIWDTVVI ILEGVPSHLN VDYIKEALMK IEDVHSVEDL
NIWSLTSGKP TAIVHIQLIP GSSSKWEEVQ SKAKHLLLNT FGMYKCTIQL QSYRQEVNRT
CANCQSSSS
