ID   CCAR1_XENLA             Reviewed;        1157 AA.
AC   Q641G3;
DT   02-MAY-2006, integrated into UniProtKB/Swiss-Prot.
DT   25-OCT-2004, sequence version 1.
DT   03-AUG-2022, entry version 78.
DE   RecName: Full=Cell division cycle and apoptosis regulator protein 1;
GN   Name=ccar1;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Embryo;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (SEP-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Transcriptional coactivator for nuclear receptors which may
CC       play an important role in regulating cell growth and apoptosis.
CC       {ECO:0000250|UniProtKB:Q8IX12}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, perinuclear region
CC       {ECO:0000250|UniProtKB:Q8IX12}.
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DR   EMBL; BC082374; AAH82374.1; -; mRNA.
DR   RefSeq; NP_001090254.1; NM_001096785.1.
DR   AlphaFoldDB; Q641G3; -.
DR   SMR; Q641G3; -.
DR   BioGRID; 607867; 1.
DR   IntAct; Q641G3; 1.
DR   MaxQB; Q641G3; -.
DR   PRIDE; Q641G3; -.
DR   DNASU; 779160; -.
DR   GeneID; 779160; -.
DR   KEGG; xla:779160; -.
DR   CTD; 779160; -.
DR   Xenbase; XB-GENE-989032; ccar1.L.
DR   OrthoDB; 614048at2759; -.
DR   Proteomes; UP000186698; Chromosome 7L.
DR   Bgee; 779160; Expressed in pancreas and 19 other tissues.
DR   GO; GO:0048471; C:perinuclear region of cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR   GO; GO:0006355; P:regulation of transcription, DNA-templated; IEA:InterPro.
DR   GO; GO:0006417; P:regulation of translation; IEA:UniProtKB-KW.
DR   Gene3D; 1.10.720.30; -; 1.
DR   InterPro; IPR045354; BURAN.
DR   InterPro; IPR025224; CCAR1/CCAR2.
DR   InterPro; IPR025954; DBC1/CARP1_inactive_NUDIX_dom.
DR   InterPro; IPR011992; EF-hand-dom_pair.
DR   InterPro; IPR045353; LAIKA.
DR   InterPro; IPR025223; S1-like_RNA-bd_dom.
DR   InterPro; IPR003034; SAP_dom.
DR   InterPro; IPR036361; SAP_dom_sf.
DR   PANTHER; PTHR14304; PTHR14304; 1.
DR   Pfam; PF19257; BURAN; 1.
DR   Pfam; PF14443; DBC1; 1.
DR   Pfam; PF19256; LAIKA; 1.
DR   Pfam; PF14444; S1-like; 1.
DR   Pfam; PF02037; SAP; 1.
DR   SMART; SM01122; DBC1; 1.
DR   SMART; SM00513; SAP; 1.
DR   SUPFAM; SSF47473; SSF47473; 1.
DR   SUPFAM; SSF68906; SSF68906; 1.
DR   PROSITE; PS50800; SAP; 1.
PE   2: Evidence at transcript level;
KW   Activator; Cell cycle; Coiled coil; Cytoplasm; Phosphoprotein;
KW   Reference proteome; Translation regulation.
FT   CHAIN           1..1157
FT                   /note="Cell division cycle and apoptosis regulator protein
FT                   1"
FT                   /id="PRO_0000233150"
FT   DOMAIN          643..677
FT                   /note="SAP"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00186"
FT   REGION          289..365
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          608..641
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          685..721
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          804..926
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          601..625
FT                   /evidence="ECO:0000255"
FT   COILED          1043..1128
FT                   /evidence="ECO:0000255"
FT   COMPBIAS        306..363
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        691..706
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        707..721
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        804..864
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        865..895
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        896..926
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         1157
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   1157 AA;  132502 MW;  8E6ED4AA8D39C3FB CRC64;
     MAQFGGQKNP PPWATQFTAT AVSQPGPLAV QQSSLLGASP TIYTQQSALA AAGLASPSPA
     NYQLSQTAAL QQQAAAAAAA AAAALQQQYT QPQQTIYSVQ QQLQPPPQAI LTQPAVALPT
     SLALSTPQQA AQITVSYPTP RSNQQQTQPQ KQRVFTGVVT KLHETFGFVD EDVFFQLTAV
     KGKSPQAGDR VLVEATYNPN MPFKWNAQRI QTLPNQNPAS AQSLIKNPAA VMQPVAQPTA
     YAVQTQPPPQ AQTLLQAQIS AATLTPLLQT QTSPLLQQPQ QKAGLLQTPV RIVSQPQPVR
     RIEPPSRFSV RNDRGDSILS RKDDRNRERE RERRRSRDRS PQRKRSRERS PRRERERSPR
     RPRRVVPRYT VQISKFCLDC PGCDTMELRR RYQNLYIPSD FFDAQFTWVD AFPISRPFQL
     GNYSNFYIMH KEVDPLEKNT AIVDPPDADH TYSAKVMLLA SPSLEELYHK SCALAEDPIE
     VREGFQHPAR LIKFLVGMKG KDEAMAIGGH WSPSLDGPNP DKDPSVLIRT AVRCCKALTG
     IELSLCTQWY RFAEIRYHRP EETHKGRTVP AHVETVVLFF PDVWHCLPTR SEWENLCHGY
     KQQLVDKLQG DRKEADGEQE EEDKEDGDAK EISTPTHWSK LDPKIMKVND LRKELESRTL
     SSKGLKSQLI ARLTKQLRIE EQKEEQKELE KCEKEEEEEE ERKSEDDKEE EERKRQEELE
     RQRREKRYML PDEPAIIVHP NWSAKNGKFD CSIMSLSVLL DYRIEDNKEH SFEVSLFAEL
     FNEMLQRDFG VRIYRELLAL PEKEEKKDKE KKCKKEDKRE RKEDKDDDDE PKPKRRKSSD
     DKIKLEEKEE RKRDDRRKED YREEDDPDYE NQDDYEPIAA EEDDGDYDDR EDDDDDSSSK
     DKREDKRDGN RYSKERQSKD KEKDKKQMVT VNRDLLMAFV YFDQSHCGYL LEKDLEEILY
     TLGLHLSRAQ VKKLFTKILL KESLLYRKLT DTATEDGSHE ETDPLHNDIL GNCSLLPSKA
     VRTGLSTVED KGGLIVYKGA MVDVGSLLQK LEKSEKTRTE LEHRLQTLES KTEEDEKTIS
     QLEASNRNLS EELKQTKDDV GHLKDSLKAA EDTRSLYEDQ LTNTIKNLSA AMGEIQVVLN
     KNPSTTEDQK SKENGSS