ZNT5_CHICK
ID ZNT5_CHICK Reviewed; 770 AA.
AC Q5ZLF4; Q5MNV7;
DT 15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT 23-NOV-2004, sequence version 1.
DT 03-AUG-2022, entry version 106.
DE RecName: Full=Zinc transporter 5;
DE Short=ZnT-5;
DE AltName: Full=Solute carrier family 30 member 5;
GN Name=SLC30A5; Synonyms=ZNT5; ORFNames=RCJMB04_6h4;
OS Gallus gallus (Chicken).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC Phasianinae; Gallus.
OX NCBI_TaxID=9031;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, AND SUBCELLULAR LOCATION.
RX PubMed=15525635; DOI=10.1074/jbc.m411247200;
RA Suzuki T., Ishihara K., Migaki H., Matsuura W., Kohda A., Okumura K.,
RA Nagao M., Yamaguchi-Iwai Y., Kambe T.;
RT "Zinc transporters, ZnT5 and ZnT7, are required for the activation of
RT alkaline phosphatases, zinc-requiring enzymes that are
RT glycosylphosphatidylinositol-anchored to the cytoplasmic membrane.";
RL J. Biol. Chem. 280:637-643(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=CB; TISSUE=Bursa of Fabricius;
RX PubMed=15642098; DOI=10.1186/gb-2004-6-1-r6;
RA Caldwell R.B., Kierzek A.M., Arakawa H., Bezzubov Y., Zaim J., Fiedler P.,
RA Kutter S., Blagodatski A., Kostovska D., Koter M., Plachy J., Carninci P.,
RA Hayashizaki Y., Buerstedde J.-M.;
RT "Full-length cDNAs from chicken bursal lymphocytes to facilitate gene
RT function analysis.";
RL Genome Biol. 6:R6.1-R6.9(2005).
CC -!- FUNCTION: Functions as a zinc transporter. Partly regulates cellular
CC zinc homeostasis. Required with ZNT7 for activation of zinc-requiring
CC enzymes, alkaline phosphatases (ALPs). Transports zinc into the lumens
CC of the Golgi apparatus and the vesicular compartments where ALPs
CC locate, thus, converting apoALPs to holoALPs. Required with ZNT6 and
CC ZNT7 for the activation of TNAP (By similarity). {ECO:0000250,
CC ECO:0000269|PubMed:15525635}.
CC -!- SUBCELLULAR LOCATION: Golgi apparatus, trans-Golgi network membrane
CC {ECO:0000269|PubMed:15525635}; Multi-pass membrane protein
CC {ECO:0000269|PubMed:15525635}.
CC -!- MISCELLANEOUS: The histidine-rich loop is essential for ZNT5 and ZNT6
CC heterooligomeric complexes to activate TNAP. {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the cation diffusion facilitator (CDF)
CC transporter (TC 2.A.4) family. SLC30A subfamily. {ECO:0000305}.
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DR EMBL; AY703476; AAV98201.1; -; mRNA.
DR EMBL; AJ719780; CAG31439.1; -; mRNA.
DR RefSeq; NP_001026590.2; NM_001031419.2.
DR AlphaFoldDB; Q5ZLF4; -.
DR SMR; Q5ZLF4; -.
DR STRING; 9031.ENSGALP00000023825; -.
DR PaxDb; Q5ZLF4; -.
DR Ensembl; ENSGALT00000079810; ENSGALP00000057176; ENSGALG00000014787.
DR GeneID; 427173; -.
DR KEGG; gga:427173; -.
DR CTD; 64924; -.
DR VEuPathDB; HostDB:geneid_427173; -.
DR eggNOG; KOG1484; Eukaryota.
DR GeneTree; ENSGT00940000155754; -.
DR HOGENOM; CLU_013430_11_0_1; -.
DR InParanoid; Q5ZLF4; -.
DR OMA; FDPPNIN; -.
DR OrthoDB; 1507860at2759; -.
DR PhylomeDB; Q5ZLF4; -.
DR Reactome; R-GGA-264876; Insulin processing.
DR Reactome; R-GGA-435368; Zinc efflux and compartmentalization by the SLC30 family.
DR PRO; PR:Q5ZLF4; -.
DR Proteomes; UP000000539; Chromosome Z.
DR Bgee; ENSGALG00000014787; Expressed in colon and 13 other tissues.
DR ExpressionAtlas; Q5ZLF4; baseline and differential.
DR GO; GO:0031410; C:cytoplasmic vesicle; IBA:GO_Central.
DR GO; GO:0005794; C:Golgi apparatus; IBA:GO_Central.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0046873; F:metal ion transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0005385; F:zinc ion transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0006882; P:cellular zinc ion homeostasis; IBA:GO_Central.
DR GO; GO:0030001; P:metal ion transport; IBA:GO_Central.
DR GO; GO:1904257; P:zinc ion import into Golgi apparatus; IBA:GO_Central.
DR Gene3D; 1.20.1510.10; -; 1.
DR InterPro; IPR002524; Cation_efflux.
DR InterPro; IPR027469; Cation_efflux_TMD_sf.
DR InterPro; IPR045316; Msc2-like.
DR PANTHER; PTHR45755; PTHR45755; 1.
DR Pfam; PF01545; Cation_efflux; 1.
DR SUPFAM; SSF161111; SSF161111; 1.
DR TIGRFAMs; TIGR01297; CDF; 1.
PE 2: Evidence at transcript level;
KW Golgi apparatus; Ion transport; Membrane; Reference proteome;
KW Transmembrane; Transmembrane helix; Transport; Zinc; Zinc transport.
FT CHAIN 1..770
FT /note="Zinc transporter 5"
FT /id="PRO_0000314295"
FT TOPO_DOM 1..29
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 30..50
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 51..53
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 54..74
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 75..95
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 96..116
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 117
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 118..138
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 139..149
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 150..170
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 171..190
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 191..211
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 212..235
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 236..256
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 257..264
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 265..285
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 286..300
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 301..321
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 322..339
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 340..360
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 361..415
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 416..436
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 437..445
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 446..466
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 467..480
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 481..501
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 502..517
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 518..538
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 539..597
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 598..618
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 619..622
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 623..643
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 644..770
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT REGION 539..579
FT /note="His-rich loop"
FT REGION 548..586
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 557..577
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CONFLICT 659
FT /note="P -> H (in Ref. 1; AAV98201)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 770 AA; 84777 MW; 34B4A35CEE781EF3 CRC64;
MEEKYSSQAL AGGGVLGPVD VPSARLTRYI VLLCFAKFLK AVGLFESYDL LKAVHLVQFI
FIVKLGSAFF MVLFQKPFSS GKVVTKHQWI KIFKHAVVGC IISLLWFFGL TLCGPLRTLL
LFEHSDVVVL SLLSVLFTSS GGGPAKTRGA AFFIIAVICL LLFDNDDLMA KIAEHPEGHH
DSALTHVLYT VIAFLGVADH KGGVLLLVLA LCCKVGFHMA SRKLSVDVGG AKRLQALSHL
VSVLLLCPWV IVLSLTTESK VESWSSLIMP FITVIFFVVI LDFYVESICS VKMESSKCAR
YGSFLIFISA LLFGNFWTHP ITDQLRAMNK PAHHESTEHV LSGGVVVSAV FFILSANILS
SPSRKGQKGT LIGYSPEGTP LYNFMGDAIQ QSSQSLPRFI KESLKQILEE YDSRQIFYFL
CLNLAFTFVE LFYGVWTNSL GLISDGFHML FDCSALVMGL FAALMTRWKA TRIFSYGYGR
VEILSGFING LFLMVIAFFV FMESVARLVD PPDIDTNMLT PVSVGGLIVN LVGICAFSHA
HSHGASRGGC HSHEHSHSYH GHSHSHGHGH SHNDHGHSHG HSHVSSGGGM NTNMRGVFLH
VLADTLGSVG VIVSTTFIQQ FGWLIADPLC SLFIATLIFL SVIPLLKDAC QVLLLRIPPE
QEKDLHAALE KIQKIDGVIS YRDPHFWCHS ASVVAGTIHV QVVSDVMEQR IVQQVTAILK
DAGVNNLTVQ VEKEAYFQHM SGLSTGFQDV LAMTQHLESM KYYKDGTYIM
