ZNT5_DANRE
ID ZNT5_DANRE Reviewed; 775 AA.
AC Q6DG36;
DT 15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT 16-AUG-2004, sequence version 1.
DT 03-AUG-2022, entry version 111.
DE RecName: Full=Zinc transporter 5;
DE Short=ZnT-5;
DE AltName: Full=Solute carrier family 30 member 5;
GN Name=slc30a5; Synonyms=znt5;
OS Danio rerio (Zebrafish) (Brachydanio rerio).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC Danionidae; Danioninae; Danio.
OX NCBI_TaxID=7955;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Embryo;
RG NIH - Zebrafish Gene Collection (ZGC) project;
RL Submitted (JUL-2004) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Functions as a zinc transporter. Partly regulates cellular
CC zinc homeostasis (By similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Golgi apparatus, trans-Golgi network membrane
CC {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the cation diffusion facilitator (CDF)
CC transporter (TC 2.A.4) family. SLC30A subfamily. {ECO:0000305}.
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DR EMBL; BC076517; AAH76517.1; -; mRNA.
DR RefSeq; NP_001002322.1; NM_001002322.1.
DR AlphaFoldDB; Q6DG36; -.
DR SMR; Q6DG36; -.
DR STRING; 7955.ENSDARP00000068124; -.
DR PaxDb; Q6DG36; -.
DR Ensembl; ENSDART00000073634; ENSDARP00000068124; ENSDARG00000051921.
DR GeneID; 436594; -.
DR KEGG; dre:436594; -.
DR CTD; 64924; -.
DR ZFIN; ZDB-GENE-040718-6; slc30a5.
DR eggNOG; KOG1484; Eukaryota.
DR GeneTree; ENSGT00940000155754; -.
DR HOGENOM; CLU_013430_11_0_1; -.
DR InParanoid; Q6DG36; -.
DR OMA; FDPPNIN; -.
DR OrthoDB; 1507860at2759; -.
DR PhylomeDB; Q6DG36; -.
DR TreeFam; TF315217; -.
DR Reactome; R-DRE-264876; Insulin processing.
DR Reactome; R-DRE-435368; Zinc efflux and compartmentalization by the SLC30 family.
DR PRO; PR:Q6DG36; -.
DR Proteomes; UP000000437; Genome assembly.
DR Proteomes; UP000814640; Chromosome 5.
DR Bgee; ENSDARG00000051921; Expressed in testis and 29 other tissues.
DR GO; GO:0031410; C:cytoplasmic vesicle; IBA:GO_Central.
DR GO; GO:0005794; C:Golgi apparatus; IBA:GO_Central.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0046873; F:metal ion transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0005385; F:zinc ion transmembrane transporter activity; ISS:ZFIN.
DR GO; GO:0006882; P:cellular zinc ion homeostasis; IBA:GO_Central.
DR GO; GO:0030001; P:metal ion transport; IBA:GO_Central.
DR GO; GO:0010043; P:response to zinc ion; IDA:ZFIN.
DR GO; GO:1904257; P:zinc ion import into Golgi apparatus; IBA:GO_Central.
DR GO; GO:0006829; P:zinc ion transport; ISS:ZFIN.
DR Gene3D; 1.20.1510.10; -; 1.
DR InterPro; IPR002524; Cation_efflux.
DR InterPro; IPR027469; Cation_efflux_TMD_sf.
DR InterPro; IPR045316; Msc2-like.
DR PANTHER; PTHR45755; PTHR45755; 2.
DR Pfam; PF01545; Cation_efflux; 1.
DR SUPFAM; SSF161111; SSF161111; 1.
DR TIGRFAMs; TIGR01297; CDF; 1.
PE 2: Evidence at transcript level;
KW Golgi apparatus; Ion transport; Membrane; Reference proteome;
KW Transmembrane; Transmembrane helix; Transport; Zinc; Zinc transport.
FT CHAIN 1..775
FT /note="Zinc transporter 5"
FT /id="PRO_0000314296"
FT TOPO_DOM 1..28
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 29..49
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 50..52
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 53..73
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 74..94
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 95..115
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 116
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 117..137
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 138..148
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 149..169
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 170..189
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 190..210
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 211..232
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 233..253
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 254..263
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 264..284
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 285..299
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 300..320
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 321..338
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 339..359
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 360..414
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 415..435
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 436..444
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 445..465
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 466..479
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 480..500
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 501..516
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 517..537
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 538..602
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 603..623
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 624..627
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 628..648
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 649..775
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT REGION 538..584
FT /note="His-rich loop"
FT REGION 547..592
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 547..574
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 775 AA; 85103 MW; 3C248C41D65A5C26 CRC64;
MDEKYSSNVI SSGKLGRVEA PNARLTRYIV LLYFTKMLKA FGIFESYDIL KVVHIVQFLF
ILKMGCAVIL VFFQKPFSSG KMIPKRQWIK ILKHAVISCI ISLLGFFGLT LCGPLRSLLL
FEHSDLVVIS LLSVLFTSSG GGPSKTRGAA FFIIAVICLL LFDNDDLMAK MAEHPEGHHD
SALTHALYTG IAFLGVADHK GGVVLLVLAL CLKVAFNTAS RKLSVEIGGA KRLYALSNLV
SAVVLLPWVI VLSATTESKV ESWSGLIFPF AMIIFSVMIL DFYVESICMA KLETSRCARY
GAIFLFLNGL LLANFWTHPL TGQIRAISTT GQQSSTEHVL SGGVLVSACF FIMADSILSA
PSSKGQKGTL VGYSPEGTPL YNFMGDALQH TSQSLPRFIK DSLKQILEEY DSRQIFYFLC
LNLAFTFVEL FYGVWTNSLG LISDGFHMLF DCSALVLGLF AALMTRWKAT RIYSYGYGRV
EILSGFINGL FLMVIAFFVF VESVTRLVDP PNINTDMLTP VSVGGLIVNL VGICAFSHAH
SHGASKGSCS GHDHGHSHHG HGHSSMEHSH GGHGHSHGGH GHSHGHGHSH SSGGMNANMR
GVFLHVLADT LGSVGVIIST ILIRQFGWLI ADPICSLFIS TLIFLSVIPL LKDACEVLLL
RMPPQHEKEL NFALEKIQKI EGVLSYRDPH FWRHSASVIA GTIHLQLMSD VVEQRVIQQV
SAVLKDAGVN NLTIQLEKEA YFQHMSGLSS GFHEVLTMTQ QMESMKYYKD GTCIM
