ZNT5_XENTR
ID ZNT5_XENTR Reviewed; 777 AA.
AC Q28CE7; Q08D30;
DT 15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT 04-APR-2006, sequence version 1.
DT 03-AUG-2022, entry version 72.
DE RecName: Full=Zinc transporter 5;
DE Short=ZnT-5;
DE AltName: Full=Solute carrier family 30 member 5;
GN Name=slc30a5; Synonyms=znt5; ORFNames=TTpA003b13.1;
OS Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX NCBI_TaxID=8364;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Tadpole;
RG Sanger Xenopus tropicalis EST/cDNA project;
RL Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=N6; TISSUE=Heart;
RG NIH - Xenopus Gene Collection (XGC) project;
RL Submitted (SEP-2006) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Functions as a zinc transporter. Partly regulates cellular
CC zinc homeostasis (By similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Golgi apparatus, trans-Golgi network membrane
CC {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the cation diffusion facilitator (CDF)
CC transporter (TC 2.A.4) family. SLC30A subfamily. {ECO:0000305}.
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DR EMBL; CR926426; CAJ83125.1; -; mRNA.
DR EMBL; BC123967; AAI23968.1; -; mRNA.
DR RefSeq; NP_001015911.1; NM_001015911.1.
DR AlphaFoldDB; Q28CE7; -.
DR SMR; Q28CE7; -.
DR STRING; 8364.ENSXETP00000001010; -.
DR DNASU; 548665; -.
DR GeneID; 548665; -.
DR KEGG; xtr:548665; -.
DR CTD; 64924; -.
DR Xenbase; XB-GENE-962722; slc30a5.
DR eggNOG; KOG1484; Eukaryota.
DR InParanoid; Q28CE7; -.
DR OrthoDB; 1507860at2759; -.
DR Reactome; R-XTR-264876; Insulin processing.
DR Reactome; R-XTR-435368; Zinc efflux and compartmentalization by the SLC30 family.
DR Proteomes; UP000008143; Chromosome 1.
DR Proteomes; UP000790000; Unplaced.
DR GO; GO:0031410; C:cytoplasmic vesicle; IBA:GO_Central.
DR GO; GO:0005794; C:Golgi apparatus; IBA:GO_Central.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0046873; F:metal ion transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0005385; F:zinc ion transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0006882; P:cellular zinc ion homeostasis; IBA:GO_Central.
DR GO; GO:0030001; P:metal ion transport; IBA:GO_Central.
DR GO; GO:1904257; P:zinc ion import into Golgi apparatus; IBA:GO_Central.
DR Gene3D; 1.20.1510.10; -; 1.
DR InterPro; IPR002524; Cation_efflux.
DR InterPro; IPR027469; Cation_efflux_TMD_sf.
DR InterPro; IPR045316; Msc2-like.
DR PANTHER; PTHR45755; PTHR45755; 2.
DR Pfam; PF01545; Cation_efflux; 1.
DR SUPFAM; SSF161111; SSF161111; 1.
DR TIGRFAMs; TIGR01297; CDF; 1.
PE 2: Evidence at transcript level;
KW Golgi apparatus; Ion transport; Membrane; Reference proteome;
KW Transmembrane; Transmembrane helix; Transport; Zinc; Zinc transport.
FT CHAIN 1..777
FT /note="Zinc transporter 5"
FT /id="PRO_0000314297"
FT TOPO_DOM 1..28
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 29..49
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 50..52
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 53..73
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 74..94
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 95..115
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 116..117
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 118..138
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 139..148
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 149..169
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 170..189
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 190..210
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 211..234
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 235..255
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 256..263
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 264..284
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 285..299
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 300..320
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 321..338
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 339..359
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 360..414
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 415..435
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 436..444
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 445..465
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 466..484
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 485..505
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 506..516
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 517..537
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 538..604
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 605..625
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 626..629
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 630..650
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 651..777
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT REGION 538..586
FT /note="His-rich loop"
FT REGION 547..593
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 556..587
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CONFLICT 307
FT /note="A -> T (in Ref. 2; AAI23968)"
FT /evidence="ECO:0000305"
FT CONFLICT 606
FT /note="S -> L (in Ref. 2; AAI23968)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 777 AA; 85724 MW; 4C6C273C0526A3A0 CRC64;
MEEKYSSNVM SSGRLGPVDA PESRLTRYIV LLCFTKFLKA LGIFESYDLL KVVHIVQFIF
ILKLGSTCFM VLFQKPFSSG KSITKRQWVS IVKHAFVSCI ISLLWFFGLT LCGPLRTLLL
FEHSDIVVIS LLTVLFTGSG GGPSKTRGAA FFIIAVICLL LFDNDDLMAK IAEHPEGHHD
SALTHFLYRA FFLLGVADHK GGVLLLVLAL CFNVGFHTAS RKLSLDIGGA KRLQALSHLV
SVIILSPWVI ILSATTESKI ESWSALIMPF MTVIFSVMIM DFYVESVCSV KMEPSKCARY
GSFLIFASAL LLGNFWTHPI TDQLRAMNKP AHQLHTEHVL SGGVVVSAIF FILSAQILAS
SSRKGQRGTL VGYSPEGTPL YNFMGDALHN TSPSMPRFLK DSLKQILEEY DSRQIFYFLC
LNLAFTFVEI FYGVWTNSLG LLSDGFHMLF DCSALVMGLI AALMTRWKAT RIFSYGYGRV
EILSGFINGL FLVVIAFFVF IEAVARIYDP PDINTDMLTP VSVGGLIVNL VGICAFSHAH
SHGAARGGCP SHDHGHSHHG HGHSHGHNHG HSHSDHGHNH GHTHNHGHSH GSAGVGMNAN
MRGVFSHVLA DTLGSVGVIV STILIRQFGW LIADPLCSLF IAVLIFGSVL PLLKDACQVI
LLRIPQETEK GINIALEKIS NLDGLISYRD PHFWRHSASL VAGTIHVQVM SDVVEQRIIQ
QVTSLLKDAG VNNLTVQVEK EAYFQHMSGL STGFQDVLIM TKQMDTIKYY KDGTYIM
