ID   ZNT6A_XENLA             Reviewed;         464 AA.
AC   Q6AZN8;
DT   04-DEC-2007, integrated into UniProtKB/Swiss-Prot.
DT   13-SEP-2004, sequence version 1.
DT   03-AUG-2022, entry version 71.
DE   RecName: Full=Zinc transporter 6-A;
DE            Short=ZnT-6-A;
DE   AltName: Full=Solute carrier family 30 member 6-A;
GN   Name=slc30a6-a; Synonyms=znt6-a;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Ovary;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (JUL-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Zinc-efflux transporter which allocates the cytoplasmic zinc
CC       to the trans-Golgi network (TGN) as well as the vesicular compartment.
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Golgi apparatus, trans-Golgi network membrane;
CC       Multi-pass membrane protein. Note=Found in vesicles. {ECO:0000250}.
CC   -!- MISCELLANEOUS: Seems to have lost most of the histidine residues in the
CC       loop between the fourth and fifth transmembrane regions and appears to
CC       exert transport function by forming complexes with znt5. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the cation diffusion facilitator (CDF)
CC       transporter (TC 2.A.4) family. SLC30A subfamily. {ECO:0000305}.
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DR   EMBL; BC077520; AAH77520.1; -; mRNA.
DR   RefSeq; NP_001086831.1; NM_001093362.1.
DR   AlphaFoldDB; Q6AZN8; -.
DR   SMR; Q6AZN8; -.
DR   DNASU; 446666; -.
DR   GeneID; 446666; -.
DR   KEGG; xla:446666; -.
DR   CTD; 446666; -.
DR   Xenbase; XB-GENE-6256667; slc30a6.L.
DR   OrthoDB; 969431at2759; -.
DR   Proteomes; UP000186698; Chromosome 5L.
DR   Bgee; 446666; Expressed in egg cell and 19 other tissues.
DR   GO; GO:0005794; C:Golgi apparatus; IEA:UniProtKB-SubCell.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0008324; F:cation transmembrane transporter activity; IEA:InterPro.
DR   GO; GO:0006829; P:zinc ion transport; IEA:UniProtKB-KW.
DR   Gene3D; 1.20.1510.10; -; 1.
DR   InterPro; IPR002524; Cation_efflux.
DR   InterPro; IPR027469; Cation_efflux_TMD_sf.
DR   Pfam; PF01545; Cation_efflux; 1.
DR   SUPFAM; SSF161111; SSF161111; 1.
DR   TIGRFAMs; TIGR01297; CDF; 1.
PE   2: Evidence at transcript level;
KW   Golgi apparatus; Ion transport; Membrane; Reference proteome;
KW   Transmembrane; Transmembrane helix; Transport; Zinc; Zinc transport.
FT   CHAIN           1..464
FT                   /note="Zinc transporter 6-A"
FT                   /id="PRO_0000312577"
FT   TOPO_DOM        1..33
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        34..54
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        55..64
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        65..85
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        86..98
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        99..119
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        120..134
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        135..155
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        156..200
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        201..221
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        222..223
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        224..244
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        245..464
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   464 AA;  51490 MW;  2FB15CE7D6D8DBA5 CRC64;
     MGTIYLFRKT QRSLLGKLAQ EFRLVTADRR SWKILLFGAI NVVCTAFLLT WCSSTNSMAL
     TAYTYLTIFD LFSLITSLIS YWVTMKKPSP TYSFGFERFE VLAVFASTVL AQLGALFILK
     ESAERFIEQP EIHTGRLLVG TFVALFFNLF TMLSIRNKPF AYVSDAASTS WLQEHVADLS
     RSLCGIIPGL SSIFLPRMNP FVLIDIAGAL ALCITYMLIE INNYFAVDTA SAVAIAVMTF
     GTMYPMSVYS GKVLLQTTPP HVIGQLDKLL REVSTLDGVL EVRNEHFWTL GFGTMAGSVH
     VRIRRDANEQ MVLAHVTNRL STLVSTLTVQ IFKDDWARPV LASGTMPPNM LNIPEHHVIQ
     MPSLKSTIDE LNPLTSTPSK PSSPPPEFAF NTPGKNMNPV ILSNNQMRPF GVGYNYGTTP
     YTTTFNQGLG VPGVGNTQGL RTGLTNVANR YGTYTPGQFT QFRQ