ID   ZNT6B_XENLA             Reviewed;         462 AA.
AC   Q6GPY1;
DT   04-DEC-2007, integrated into UniProtKB/Swiss-Prot.
DT   19-JUL-2004, sequence version 1.
DT   03-AUG-2022, entry version 70.
DE   RecName: Full=Zinc transporter 6-B;
DE            Short=ZnT-6-B;
DE   AltName: Full=Solute carrier family 30 member 6-B;
GN   Name=slc30a6-b; Synonyms=znt6-b;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Spleen;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Zinc-efflux transporter which allocates the cytoplasmic zinc
CC       to the trans-Golgi network (TGN) as well as the vesicular compartment.
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Golgi apparatus, trans-Golgi network membrane;
CC       Multi-pass membrane protein. Note=Found in vesicles. {ECO:0000250}.
CC   -!- MISCELLANEOUS: Seems to have lost most of the histidine residues in the
CC       loop between the fourth and fifth transmembrane regions and appears to
CC       exert transport function by forming complexes with znt5. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the cation diffusion facilitator (CDF)
CC       transporter (TC 2.A.4) family. SLC30A subfamily. {ECO:0000305}.
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DR   EMBL; BC072974; AAH72974.1; -; mRNA.
DR   RefSeq; NP_001085582.1; NM_001092113.1.
DR   AlphaFoldDB; Q6GPY1; -.
DR   SMR; Q6GPY1; -.
DR   DNASU; 444008; -.
DR   GeneID; 444008; -.
DR   KEGG; xla:444008; -.
DR   CTD; 444008; -.
DR   Xenbase; XB-GENE-5779516; slc30a6.S.
DR   OrthoDB; 969431at2759; -.
DR   Proteomes; UP000186698; Chromosome 5S.
DR   Bgee; 444008; Expressed in egg cell and 19 other tissues.
DR   GO; GO:0005794; C:Golgi apparatus; IEA:UniProtKB-SubCell.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0008324; F:cation transmembrane transporter activity; IEA:InterPro.
DR   GO; GO:0006829; P:zinc ion transport; IEA:UniProtKB-KW.
DR   Gene3D; 1.20.1510.10; -; 1.
DR   InterPro; IPR002524; Cation_efflux.
DR   InterPro; IPR027469; Cation_efflux_TMD_sf.
DR   Pfam; PF01545; Cation_efflux; 1.
DR   SUPFAM; SSF161111; SSF161111; 1.
DR   TIGRFAMs; TIGR01297; CDF; 1.
PE   2: Evidence at transcript level;
KW   Golgi apparatus; Ion transport; Membrane; Reference proteome;
KW   Transmembrane; Transmembrane helix; Transport; Zinc; Zinc transport.
FT   CHAIN           1..462
FT                   /note="Zinc transporter 6-B"
FT                   /id="PRO_0000312578"
FT   TOPO_DOM        1..33
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        34..54
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        55..64
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        65..85
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        86..98
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        99..119
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        120..134
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        135..155
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        156..200
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        201..221
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        222..223
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        224..244
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        245..462
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   462 AA;  51166 MW;  20D9EA5635FE3DE9 CRC64;
     MGTIYLFRKT QRSLLGKLTQ EFRLVTADRR SWKILLFGAI NVVCTGFLLT WCSSTNSMAL
     TAYTYLTIFD LFSLITSLIS YWVMMKKPSP TYSFGFERLE VLAVFASTVL AQLGALFILK
     ESAERFLEQP EIHTGRLLVG TFVALFFNLF TMLSIRNKPF AYVSEAASTS WLQEHVADLS
     RSLCGVIPGL SSIFLPRMNP FVLIDIAGAL ALCITYMLIE INNYFAVDTA SAIAIAVMTF
     GTMYPMSVYS GKVLLQTTPP HVIGQLDKLL REVSTLDGVL EVRNEHFWTL GFGTMAGSVH
     VRIRRDANEQ MVLAHVTNRL STLVSTPTVQ IFKDDWARPV LASGTMPPNM LNIPEHHVIQ
     MPSLKSTVDE LNPMTSTPSK PSGPPPEFAF NTPGKNMNPV ILSNNQTRPF GVGYGTTPYT
     TTFNQGLGVP GVGNTQGLRT GLTNVANRYG TYTPGQFTQF RQ