ID   ZNT6_BOVIN              Reviewed;         461 AA.
AC   Q0VC54;
DT   04-DEC-2007, integrated into UniProtKB/Swiss-Prot.
DT   05-SEP-2006, sequence version 1.
DT   03-AUG-2022, entry version 98.
DE   RecName: Full=Zinc transporter 6;
DE            Short=ZnT-6;
DE   AltName: Full=Solute carrier family 30 member 6;
GN   Name=SLC30A6; Synonyms=ZNT6;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Hereford; TISSUE=Fetal skin;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Zinc-efflux transporter which allocates the cytoplasmic zinc
CC       to the trans-Golgi network (TGN) as well as the vesicular compartment.
CC       {ECO:0000250}.
CC   -!- SUBUNIT: Heterooligomer. Interacts with ZNT5 (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Golgi apparatus, trans-Golgi network membrane;
CC       Multi-pass membrane protein. Note=Found in vesicles. {ECO:0000250}.
CC   -!- MISCELLANEOUS: Seems to have lost most of the histidine residues in the
CC       loop between the fourth and fifth transmembrane regions and appears to
CC       exert transport function by forming complexes with ZNT5. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the cation diffusion facilitator (CDF)
CC       transporter (TC 2.A.4) family. SLC30A subfamily. {ECO:0000305}.
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DR   EMBL; BC120350; AAI20351.1; -; mRNA.
DR   RefSeq; NP_001069234.1; NM_001075766.1.
DR   AlphaFoldDB; Q0VC54; -.
DR   SMR; Q0VC54; -.
DR   STRING; 9913.ENSBTAP00000014475; -.
DR   PaxDb; Q0VC54; -.
DR   PRIDE; Q0VC54; -.
DR   Ensembl; ENSBTAT00000014475; ENSBTAP00000014475; ENSBTAG00000010898.
DR   GeneID; 518111; -.
DR   KEGG; bta:518111; -.
DR   CTD; 55676; -.
DR   VEuPathDB; HostDB:ENSBTAG00000010898; -.
DR   VGNC; VGNC:34810; SLC30A6.
DR   eggNOG; KOG1484; Eukaryota.
DR   GeneTree; ENSGT00940000159934; -.
DR   HOGENOM; CLU_034201_0_0_1; -.
DR   InParanoid; Q0VC54; -.
DR   OMA; EINNYYA; -.
DR   OrthoDB; 969431at2759; -.
DR   TreeFam; TF313167; -.
DR   Proteomes; UP000009136; Chromosome 11.
DR   Bgee; ENSBTAG00000010898; Expressed in spermatocyte and 106 other tissues.
DR   ExpressionAtlas; Q0VC54; baseline and differential.
DR   GO; GO:0005794; C:Golgi apparatus; IBA:GO_Central.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005385; F:zinc ion transmembrane transporter activity; IBA:GO_Central.
DR   GO; GO:0006829; P:zinc ion transport; IBA:GO_Central.
DR   Gene3D; 1.20.1510.10; -; 1.
DR   InterPro; IPR002524; Cation_efflux.
DR   InterPro; IPR027469; Cation_efflux_TMD_sf.
DR   Pfam; PF01545; Cation_efflux; 1.
DR   SUPFAM; SSF161111; SSF161111; 1.
DR   TIGRFAMs; TIGR01297; CDF; 1.
PE   2: Evidence at transcript level;
KW   Golgi apparatus; Ion transport; Membrane; Reference proteome;
KW   Transmembrane; Transmembrane helix; Transport; Zinc; Zinc transport.
FT   CHAIN           1..461
FT                   /note="Zinc transporter 6"
FT                   /id="PRO_0000312572"
FT   TOPO_DOM        1..33
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        34..54
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        55..64
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        65..85
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        86..98
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        99..119
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        120..134
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        135..155
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        156..200
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        201..221
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        222..223
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        224..244
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        245..461
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   REGION          362..393
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   461 AA;  50932 MW;  AC81E38C9B25BA53 CRC64;
     MGTIHLFRKP QRSFFGKLLQ EFRLVAADRR SWKILLFGAI NLTCTGFLLM WCSSTNSIAL
     TAYTYLTIFD LFSLITCLVS YWVMMRKPSP AYSFGFERLE VLAVFASTVL AQLGALFILK
     ESAERFLEQP EIHTGRLLVG TFVALSFNLF TMLSIRNKPF AYVSEAASTS WLQEHVADLS
     RSLCGIIPGL SSIFLPRMNP FVLIDLAGAF ALCITYMLIE INNYFAVDTA SAIAIALMTF
     GTMYPMSVYS GKVLLQTTPP HVIGQLDKLI REVSTLDGVL EVRNEHFWTL GFGSLAGSVH
     VRIRRDANEQ MVLAHVTNRL YTLVSTLTVQ IFKDDWIRPA LLSGPVAANV LNFTDHHVIP
     MPPLKGTDDS NPVTSTPTKP SSPPPEFSFN TPGKNVSPVI LLNTQTRPYG LGLNHGHAPY
     SSVLNQGLGV PGIGATQGFR TGFTNIPSRY GTNNRIGQPR P