ZNT6_CHICK
ID ZNT6_CHICK Reviewed; 460 AA.
AC Q5ZIH3;
DT 04-DEC-2007, integrated into UniProtKB/Swiss-Prot.
DT 23-NOV-2004, sequence version 1.
DT 03-AUG-2022, entry version 104.
DE RecName: Full=Zinc transporter 6;
DE Short=ZnT-6;
DE AltName: Full=Solute carrier family 30 member 6;
GN Name=SLC30A6; Synonyms=ZNT6; ORFNames=RCJMB04_26e2;
OS Gallus gallus (Chicken).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC Phasianinae; Gallus.
OX NCBI_TaxID=9031;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, SUBUNIT, AND SUBCELLULAR LOCATION.
RX PubMed=15994300; DOI=10.1074/jbc.m506902200;
RA Suzuki T., Ishihara K., Migaki H., Ishihara K., Nagao M.,
RA Yamaguchi-Iwai Y., Kambe T.;
RT "Two different zinc transport complexes of cation diffusion facilitator
RT proteins localized in the secretory pathway operate to activate alkaline
RT phosphatases in vertebrate cells.";
RL J. Biol. Chem. 280:30956-30962(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=CB; TISSUE=Bursa of Fabricius;
RX PubMed=15642098; DOI=10.1186/gb-2004-6-1-r6;
RA Caldwell R.B., Kierzek A.M., Arakawa H., Bezzubov Y., Zaim J., Fiedler P.,
RA Kutter S., Blagodatski A., Kostovska D., Koter M., Plachy J., Carninci P.,
RA Hayashizaki Y., Buerstedde J.-M.;
RT "Full-length cDNAs from chicken bursal lymphocytes to facilitate gene
RT function analysis.";
RL Genome Biol. 6:R6.1-R6.9(2005).
CC -!- FUNCTION: Zinc-efflux transporter which allocates the cytoplasmic zinc
CC to the trans-Golgi network (TGN) as well as the vesicular compartment.
CC {ECO:0000269|PubMed:15994300}.
CC -!- SUBUNIT: Heterooligomer. Interacts with ZNT5.
CC {ECO:0000269|PubMed:15994300}.
CC -!- SUBCELLULAR LOCATION: Golgi apparatus, trans-Golgi network membrane
CC {ECO:0000269|PubMed:15994300}; Multi-pass membrane protein
CC {ECO:0000269|PubMed:15994300}. Note=Found in vesicles.
CC -!- MISCELLANEOUS: Seems to have lost most of the histidine residues in the
CC loop between the fourth and fifth transmembrane regions and appears to
CC exert transport function by forming complexes with ZNT5. {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the cation diffusion facilitator (CDF)
CC transporter (TC 2.A.4) family. SLC30A subfamily. {ECO:0000305}.
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DR EMBL; AJ720811; CAG32470.1; -; mRNA.
DR EMBL; AY986776; AAY53770.1; -; mRNA.
DR RefSeq; NP_001006402.1; NM_001006402.1.
DR AlphaFoldDB; Q5ZIH3; -.
DR SMR; Q5ZIH3; -.
DR STRING; 9031.ENSGALP00000017255; -.
DR PaxDb; Q5ZIH3; -.
DR GeneID; 421480; -.
DR KEGG; gga:421480; -.
DR CTD; 55676; -.
DR VEuPathDB; HostDB:geneid_421480; -.
DR eggNOG; KOG1484; Eukaryota.
DR HOGENOM; CLU_034201_0_0_1; -.
DR InParanoid; Q5ZIH3; -.
DR OrthoDB; 969431at2759; -.
DR PhylomeDB; Q5ZIH3; -.
DR TreeFam; TF313167; -.
DR PRO; PR:Q5ZIH3; -.
DR Proteomes; UP000000539; Unplaced.
DR GO; GO:0005794; C:Golgi apparatus; IBA:GO_Central.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005385; F:zinc ion transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0006829; P:zinc ion transport; IBA:GO_Central.
DR Gene3D; 1.20.1510.10; -; 1.
DR InterPro; IPR002524; Cation_efflux.
DR InterPro; IPR027469; Cation_efflux_TMD_sf.
DR Pfam; PF01545; Cation_efflux; 1.
DR SUPFAM; SSF161111; SSF161111; 1.
DR TIGRFAMs; TIGR01297; CDF; 1.
PE 1: Evidence at protein level;
KW Golgi apparatus; Ion transport; Membrane; Reference proteome;
KW Transmembrane; Transmembrane helix; Transport; Zinc; Zinc transport.
FT CHAIN 1..460
FT /note="Zinc transporter 6"
FT /id="PRO_0000312575"
FT TOPO_DOM 1..33
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 34..54
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 55..64
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 65..85
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 86..98
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 99..119
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 120..134
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 135..155
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 156..200
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 201..221
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 222..228
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 229..249
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 250..460
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT REGION 372..392
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 460 AA; 50936 MW; 6D9EB207DC180E82 CRC64;
MGTIHLFRKS QRSLVGKLTH EFRLVAADRR SWKILLFGAI NLICIGFLLM WCSSTNSIAL
TAYTYLTIFD LFSLITCLIS YWVMVKKPSP VYSFGFERFE VLAVFASTVL AQLGALFILK
ESAERFLEQP EIHTGRLLVG TFVALFFNLF TMLSVRNKPF AYVSEAASTS WLQEHVADLS
RSICGIIPGL SSIFLPRMNP FVLIDIAGAL ALCITYMLIE INNYYAVDTA SAIAIALMTF
GTMYPMSVYS GKVLLQTTPP HVFGQLDKLL REVSTLDGVL EVRNEHFWTL GFGTLAGSVH
VRIRRDANEQ MVLAHVTNRL YTLVSTLTVQ IFKDDWIRPT LSSVPIANNM LNLSDHHVIT
MPSLKAADNL NPVTSTPAKP SSPPPEFSFN TPGKNVNPVI LLNTQTRPYG LGLNHGSTPY
SSVLNQGFGI PGMGATQGFR TGFTNVPSRY GTNTRGQSRP
