ID   ZNT6_DANRE              Reviewed;         486 AA.
AC   Q6P0D1; Q6PE38;
DT   04-DEC-2007, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   03-AUG-2022, entry version 90.
DE   RecName: Full=Zinc transporter 6;
DE            Short=ZnT-6;
DE   AltName: Full=Solute carrier family 30 member 6;
GN   Name=slc30a6; Synonyms=znt6;
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Danionidae; Danioninae; Danio.
OX   NCBI_TaxID=7955;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Embryo;
RG   NIH - Zebrafish Gene Collection (ZGC) project;
RL   Submitted (JAN-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Zinc-efflux transporter which allocates the cytoplasmic zinc
CC       to the trans-Golgi network (TGN) as well as the vesicular compartment.
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Golgi apparatus, trans-Golgi network membrane;
CC       Multi-pass membrane protein. Note=Found in vesicles. {ECO:0000250}.
CC   -!- MISCELLANEOUS: Seems to have lost most of the histidine residues in the
CC       loop between the fourth and fifth transmembrane regions and appears to
CC       exert transport function by forming complexes with znt5. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the cation diffusion facilitator (CDF)
CC       transporter (TC 2.A.4) family. SLC30A subfamily. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAH58300.1; Type=Frameshift; Evidence={ECO:0000305};
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DR   EMBL; BC058300; AAH58300.1; ALT_FRAME; mRNA.
DR   EMBL; BC065666; AAH65666.1; -; mRNA.
DR   RefSeq; NP_991214.1; NM_205651.1.
DR   AlphaFoldDB; Q6P0D1; -.
DR   STRING; 7955.ENSDARP00000060344; -.
DR   PaxDb; Q6P0D1; -.
DR   GeneID; 402949; -.
DR   KEGG; dre:402949; -.
DR   CTD; 55676; -.
DR   ZFIN; ZDB-GENE-040426-1838; slc30a6.
DR   eggNOG; KOG1484; Eukaryota.
DR   InParanoid; Q6P0D1; -.
DR   OrthoDB; 969431at2759; -.
DR   PhylomeDB; Q6P0D1; -.
DR   Reactome; R-DRE-264876; Insulin processing.
DR   Reactome; R-DRE-435368; Zinc efflux and compartmentalization by the SLC30 family.
DR   PRO; PR:Q6P0D1; -.
DR   Proteomes; UP000000437; Genome assembly.
DR   Proteomes; UP000814640; Unplaced.
DR   GO; GO:0005794; C:Golgi apparatus; IBA:GO_Central.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005385; F:zinc ion transmembrane transporter activity; ISS:ZFIN.
DR   GO; GO:0006829; P:zinc ion transport; ISS:ZFIN.
DR   Gene3D; 1.20.1510.10; -; 1.
DR   InterPro; IPR002524; Cation_efflux.
DR   InterPro; IPR027469; Cation_efflux_TMD_sf.
DR   Pfam; PF01545; Cation_efflux; 1.
DR   SUPFAM; SSF161111; SSF161111; 1.
PE   2: Evidence at transcript level;
KW   Golgi apparatus; Ion transport; Membrane; Reference proteome;
KW   Transmembrane; Transmembrane helix; Transport; Zinc; Zinc transport.
FT   CHAIN           1..486
FT                   /note="Zinc transporter 6"
FT                   /id="PRO_0000312576"
FT   TOPO_DOM        1..60
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        61..81
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        82..91
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        92..112
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        113..125
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        126..146
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        147..161
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        162..182
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        183..227
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        228..248
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        249..255
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        256..276
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        277..486
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   REGION          394..425
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   486 AA;  53172 MW;  7ED3E5B09BA04C6F CRC64;
     MVALDVLGIT DSDAPVYRQK QEADTLVLGT IHPFRKAHRS VLGKLAQEFR LVTSDRRSWK
     ILLFGVLNVV CTGCLLMWCS STNSMALTAY TYLTIFDLFS LITCLLSLWV TMKKPSQIYS
     FGFQRFEVLA VFSSTVLVQL GSLFILKESV ERFVEQPEVH TGRLLVGTFV ALFFNLLTLL
     SVKNKPFVFV SEAASTSWLQ EHVADLSRSL CGLIPALSSF LLPRMNPFVL INLAGAFALG
     ITYMLIEINN YNAMDTASAV AIALMTFGTM YPMSVYSGKV LLQTTPSHVI GQLDKLLREV
     STLDGVLEVR NEHFWTIGFG SLAGSVHVRI RRDADEQMVL AHVWNRLSAL VSALTVHVFK
     DEWSRASLSS GVLPSAPLSL SEYVTAAAVF PAAPSRAQGS EPTPATSTPA KPSSPPPEFS
     FHTPGRHVQP VVFQTAHPHR PLYGGLQGPG VRLGLGPRGP TLQAYRTLSA APHTYTSGTY
     TGPPRP