ID   ZNT6_XENTR              Reviewed;         464 AA.
AC   Q5I0B2; Q28EI6;
DT   04-DEC-2007, integrated into UniProtKB/Swiss-Prot.
DT   15-FEB-2005, sequence version 1.
DT   03-AUG-2022, entry version 84.
DE   RecName: Full=Zinc transporter 6;
DE            Short=ZnT-6;
DE   AltName: Full=Solute carrier family 30 member 6;
GN   Name=slc30a6; Synonyms=znt6; ORFNames=TEgg064j23.1, TTpA009a14.1;
OS   Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX   NCBI_TaxID=8364;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Egg, and Tadpole;
RG   Sanger Xenopus tropicalis EST/cDNA project;
RL   Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Embryo;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (DEC-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Zinc-efflux transporter which allocates the cytoplasmic zinc
CC       to the trans-Golgi network (TGN) as well as the vesicular compartment.
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Golgi apparatus, trans-Golgi network membrane;
CC       Multi-pass membrane protein. Note=Found in vesicles. {ECO:0000250}.
CC   -!- MISCELLANEOUS: Seems to have lost most of the histidine residues in the
CC       loop between the fourth and fifth transmembrane regions and appears to
CC       exert transport function by forming complexes with znt5. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the cation diffusion facilitator (CDF)
CC       transporter (TC 2.A.4) family. SLC30A subfamily. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; CR761129; CAJ82110.1; -; mRNA.
DR   EMBL; CR848235; CAJ82938.1; -; mRNA.
DR   EMBL; BC088526; AAH88526.1; -; mRNA.
DR   RefSeq; NP_001011444.1; NM_001011444.1.
DR   AlphaFoldDB; Q5I0B2; -.
DR   SMR; Q5I0B2; -.
DR   STRING; 8364.ENSXETP00000054089; -.
DR   PaxDb; Q5I0B2; -.
DR   DNASU; 496932; -.
DR   Ensembl; ENSXETT00000054089; ENSXETP00000054089; ENSXETG00000008384.
DR   GeneID; 496932; -.
DR   KEGG; xtr:496932; -.
DR   CTD; 55676; -.
DR   Xenbase; XB-GENE-5779445; slc30a6.
DR   eggNOG; KOG1484; Eukaryota.
DR   InParanoid; Q5I0B2; -.
DR   OrthoDB; 969431at2759; -.
DR   Reactome; R-XTR-264876; Insulin processing.
DR   Reactome; R-XTR-435368; Zinc efflux and compartmentalization by the SLC30 family.
DR   Proteomes; UP000008143; Chromosome 5.
DR   Proteomes; UP000790000; Unplaced.
DR   Bgee; ENSXETG00000008384; Expressed in egg cell and 13 other tissues.
DR   GO; GO:0005794; C:Golgi apparatus; IBA:GO_Central.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005385; F:zinc ion transmembrane transporter activity; IBA:GO_Central.
DR   GO; GO:0006829; P:zinc ion transport; IBA:GO_Central.
DR   Gene3D; 1.20.1510.10; -; 1.
DR   InterPro; IPR002524; Cation_efflux.
DR   InterPro; IPR027469; Cation_efflux_TMD_sf.
DR   Pfam; PF01545; Cation_efflux; 1.
DR   SUPFAM; SSF161111; SSF161111; 1.
DR   TIGRFAMs; TIGR01297; CDF; 1.
PE   2: Evidence at transcript level;
KW   Golgi apparatus; Ion transport; Membrane; Reference proteome;
KW   Transmembrane; Transmembrane helix; Transport; Zinc; Zinc transport.
FT   CHAIN           1..464
FT                   /note="Zinc transporter 6"
FT                   /id="PRO_0000312579"
FT   TOPO_DOM        1..33
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        34..54
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        55..64
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        65..85
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        86..98
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        99..119
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        120..134
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        135..155
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        156..200
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        201..221
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        222..228
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        229..249
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        250..464
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   464 AA;  51432 MW;  DF12D84BD7A60374 CRC64;
     MGTIYLFRKT QRSLLGKLTQ EFRLVTADRR SWKILLFGAI NVVCTGFLLT WCSSTNSMAL
     TAYTYLTIFD LFSLITCLIS YWVMMKKPSP TYSFGFERFE VLSVFASTVL AQLGALFILK
     ESAERFVEQP EIHTGRLLVG TFVALCFNLF SMLSIRNKPF AYVSEAASTS WLQEHVADLS
     RSLCGIIPGL SSIFLPRMNP FVLIDIAGAL ALCITYMLIE INNYFAVDTA SAIAIAVMTF
     GTMYPMSVYS GKVLLQTTPP HVIGQLDKLL REVSTLDGVL EVRNEHFWTL GFGTMAGSVH
     VRIRRDANEQ MVLAHVTNRL NTLVSSLTVQ IFKDEWARPV LASGAMPPNM LNIPDHHVIQ
     MPSLKSTMDE LNPMTSTPSK PSSPPPEFAF NTPGKNMNPV ILSNNQTRPS GVGFNYGTTP
     YTTTFNHGLG VPGIGNTQGL RTGLTNVANR YGTYTPGQFT QFKQ