ID   ZNT7A_XENLA             Reviewed;         386 AA.
AC   Q52KD7;
DT   15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT   24-MAY-2005, sequence version 1.
DT   03-AUG-2022, entry version 67.
DE   RecName: Full=Zinc transporter 7-A;
DE            Short=ZnT-7-A;
DE   AltName: Full=Solute carrier family 30 member 7-A;
GN   Name=slc30a7-a; Synonyms=znt7-a;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Egg;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Seems to facilitate zinc transport from the cytoplasm into
CC       the Golgi apparatus. Partly regulates cellular zinc homeostasis (By
CC       similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Homooligomer. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Golgi apparatus, trans-Golgi network membrane
CC       {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the cation diffusion facilitator (CDF)
CC       transporter (TC 2.A.4) family. SLC30A subfamily. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; BC094400; AAH94400.1; -; mRNA.
DR   RefSeq; NP_001089424.1; NM_001095955.1.
DR   AlphaFoldDB; Q52KD7; -.
DR   SMR; Q52KD7; -.
DR   DNASU; 734474; -.
DR   GeneID; 734474; -.
DR   KEGG; xla:734474; -.
DR   CTD; 734474; -.
DR   Xenbase; XB-GENE-6256185; slc30a7.S.
DR   OrthoDB; 1507860at2759; -.
DR   Proteomes; UP000186698; Chromosome 4S.
DR   Bgee; 734474; Expressed in egg cell and 19 other tissues.
DR   GO; GO:0005794; C:Golgi apparatus; IEA:UniProtKB-SubCell.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005385; F:zinc ion transmembrane transporter activity; IEA:InterPro.
DR   GO; GO:0006882; P:cellular zinc ion homeostasis; IEA:InterPro.
DR   Gene3D; 1.20.1510.10; -; 1.
DR   InterPro; IPR002524; Cation_efflux.
DR   InterPro; IPR027469; Cation_efflux_TMD_sf.
DR   InterPro; IPR045316; Msc2-like.
DR   PANTHER; PTHR45755; PTHR45755; 2.
DR   Pfam; PF01545; Cation_efflux; 1.
DR   SUPFAM; SSF161111; SSF161111; 1.
DR   TIGRFAMs; TIGR01297; CDF; 1.
PE   2: Evidence at transcript level;
KW   Golgi apparatus; Ion transport; Membrane; Reference proteome;
KW   Transmembrane; Transmembrane helix; Transport; Zinc; Zinc transport.
FT   CHAIN           1..386
FT                   /note="Zinc transporter 7-A"
FT                   /id="PRO_0000314304"
FT   TOPO_DOM        1..37
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        38..58
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        59..67
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        68..88
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        89..102
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        103..123
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        124..140
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        141..161
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        162..246
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        247..267
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        268..272
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        273..293
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        294..386
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   REGION          161..222
FT                   /note="His-rich loop"
FT   REGION          167..239
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        192..239
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   386 AA;  42547 MW;  3A0F5595CE39D8C8 CRC64;
     MLPLSIKDDE YKPPKFNLAR KVSGWIRSIF SDSTSRNLFC FLCLNLSFAF VELFYGIWSN
     SLGLISDSFH MFFDCTALLA GLAASVISRW KTNEAFSYGY VRAEVLAGFV NGLFLIFTAF
     FIFSEGVERA LDTPEVHHER LLPVSIMGLL VNIIGIFVFQ HGGGHGHSHE SGHGHSHSLF
     NGAVSHGHSH GGGHGHSHEG GHGHSHSQGG GHGHSHDHSP KHGYGSSCHD EPPEEHKGSS
     KQILEGVFLH IVADTLGSVG VIFSTILMQR YGLMIADPIC SMLIALLIFV SVIPLLKQSI
     GILMQRTPPA LDHVLPQCYQ RVQQLQGVYH LQEPHFWTLC TDVYIGTLKL VIGPEADARW
     ILSQTHNIFT QAGVRQLYVQ IDFAAI