ID   ZNT7B_XENLA             Reviewed;         390 AA.
AC   Q6NRI1;
DT   15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   03-AUG-2022, entry version 77.
DE   RecName: Full=Zinc transporter 7-B;
DE            Short=ZnT-7-B;
DE   AltName: Full=Solute carrier family 30 member 7-B;
GN   Name=slc30a7-b; Synonyms=znt7-b;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Oocyte;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (MAY-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Seems to facilitate zinc transport from the cytoplasm into
CC       the Golgi apparatus. Partly regulates cellular zinc homeostasis (By
CC       similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Homooligomer. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Golgi apparatus, trans-Golgi network membrane
CC       {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the cation diffusion facilitator (CDF)
CC       transporter (TC 2.A.4) family. SLC30A subfamily. {ECO:0000305}.
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DR   EMBL; BC070769; AAH70769.1; -; mRNA.
DR   RefSeq; NP_001084857.1; NM_001091388.1.
DR   AlphaFoldDB; Q6NRI1; -.
DR   SMR; Q6NRI1; -.
DR   DNASU; 431904; -.
DR   GeneID; 431904; -.
DR   KEGG; xla:431904; -.
DR   CTD; 431904; -.
DR   Xenbase; XB-GENE-977020; slc30a7.L.
DR   OMA; WKRLIFS; -.
DR   OrthoDB; 1507860at2759; -.
DR   Proteomes; UP000186698; Chromosome 4L.
DR   Bgee; 431904; Expressed in liver and 19 other tissues.
DR   GO; GO:0005794; C:Golgi apparatus; IEA:UniProtKB-SubCell.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005385; F:zinc ion transmembrane transporter activity; IEA:InterPro.
DR   GO; GO:0006882; P:cellular zinc ion homeostasis; IEA:InterPro.
DR   Gene3D; 1.20.1510.10; -; 1.
DR   InterPro; IPR002524; Cation_efflux.
DR   InterPro; IPR027469; Cation_efflux_TMD_sf.
DR   InterPro; IPR045316; Msc2-like.
DR   PANTHER; PTHR45755; PTHR45755; 2.
DR   Pfam; PF01545; Cation_efflux; 1.
DR   SUPFAM; SSF161111; SSF161111; 1.
DR   TIGRFAMs; TIGR01297; CDF; 1.
PE   2: Evidence at transcript level;
KW   Golgi apparatus; Ion transport; Membrane; Reference proteome;
KW   Transmembrane; Transmembrane helix; Transport; Zinc; Zinc transport.
FT   CHAIN           1..390
FT                   /note="Zinc transporter 7-B"
FT                   /id="PRO_0000314305"
FT   TOPO_DOM        1..37
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        38..58
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        59..67
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        68..88
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        89..102
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        103..123
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        124..140
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        141..161
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        162..250
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        251..271
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        272..276
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        277..297
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        298..390
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   REGION          161..226
FT                   /note="His-rich loop"
FT   REGION          166..243
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        198..242
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   390 AA;  43017 MW;  000F31A3D2D3640B CRC64;
     MLPLSIKDDE YKPPKFNLVR KVSGWIRSIF SDSTSRNLFC FLCLNLSFAF VELFYGIWSN
     SLGLISDSFH MFFDCTALLA GLAASVISRW KTNETFSYGY VRAEVLAGFV NGLFLIFTAF
     FIFSEGIERA LDTPEVHHER LLPVSIMGFL VNLIGIFVFQ HGGGHGHSHE SGHGHSHSLF
     NGAVSHGHSH SHGGGHGHSH GGGHEHGHSH GGGHEHGHDH SHKHGHGYGS SCHDEPPEEN
     KGSSKQILEG VFLHIVADAL GSVGVIISTI LMQQYGLMIA DPICSMLIAL LIFVSVIPLL
     KQSIGILMQR TPPSLDHVLP QCYQRVQQLQ GVYHLQEPHF WTLCTDVYIG TLKLVIGPEA
     DARWILSQTH NIFTQAGVRQ LYVQIDLAAM