ZNT7_BOVIN
ID ZNT7_BOVIN Reviewed; 376 AA.
AC A4IFD7;
DT 15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-2007, sequence version 1.
DT 03-AUG-2022, entry version 94.
DE RecName: Full=Zinc transporter 7;
DE Short=ZnT-7;
DE AltName: Full=Solute carrier family 30 member 7;
GN Name=SLC30A7; Synonyms=ZNT7;
OS Bos taurus (Bovine).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Bovinae; Bos.
OX NCBI_TaxID=9913;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Hereford; TISSUE=Ascending colon;
RG NIH - Mammalian Gene Collection (MGC) project;
RL Submitted (MAR-2007) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Seems to facilitate zinc transport from the cytoplasm into
CC the Golgi apparatus. Partly regulates cellular zinc homeostasis.
CC Required with ZNT5 for the activation of zinc-requiring enzymes,
CC alkaline phosphatases (ALPs). Transports zinc into the lumens of the
CC Golgi apparatus and the vesicular compartments where ALPs locate, thus,
CC converting apoALPs to holoALPs. Required with ZNT5 and ZNT6 for the
CC activation of TNAP (By similarity). {ECO:0000250}.
CC -!- SUBUNIT: Homooligomer. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Golgi apparatus, trans-Golgi network membrane
CC {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the cation diffusion facilitator (CDF)
CC transporter (TC 2.A.4) family. SLC30A subfamily. {ECO:0000305}.
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DR EMBL; BC134531; AAI34532.1; -; mRNA.
DR RefSeq; NP_001077229.1; NM_001083760.1.
DR AlphaFoldDB; A4IFD7; -.
DR SMR; A4IFD7; -.
DR STRING; 9913.ENSBTAP00000025323; -.
DR PaxDb; A4IFD7; -.
DR PRIDE; A4IFD7; -.
DR Ensembl; ENSBTAT00000025323; ENSBTAP00000025323; ENSBTAG00000019027.
DR GeneID; 613851; -.
DR KEGG; bta:613851; -.
DR CTD; 148867; -.
DR VEuPathDB; HostDB:ENSBTAG00000019027; -.
DR VGNC; VGNC:34811; SLC30A7.
DR eggNOG; KOG1484; Eukaryota.
DR GeneTree; ENSGT00940000159571; -.
DR HOGENOM; CLU_013430_0_3_1; -.
DR InParanoid; A4IFD7; -.
DR OMA; WKRLIFS; -.
DR OrthoDB; 1507860at2759; -.
DR TreeFam; TF315217; -.
DR Proteomes; UP000009136; Chromosome 3.
DR Bgee; ENSBTAG00000019027; Expressed in neutrophil and 108 other tissues.
DR GO; GO:0031410; C:cytoplasmic vesicle; IBA:GO_Central.
DR GO; GO:0005794; C:Golgi apparatus; IBA:GO_Central.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0048471; C:perinuclear region of cytoplasm; IEA:Ensembl.
DR GO; GO:0046873; F:metal ion transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0005385; F:zinc ion transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0006882; P:cellular zinc ion homeostasis; IBA:GO_Central.
DR GO; GO:0030001; P:metal ion transport; IBA:GO_Central.
DR GO; GO:0032119; P:sequestering of zinc ion; IEA:Ensembl.
DR GO; GO:1904257; P:zinc ion import into Golgi apparatus; IBA:GO_Central.
DR Gene3D; 1.20.1510.10; -; 1.
DR InterPro; IPR002524; Cation_efflux.
DR InterPro; IPR027469; Cation_efflux_TMD_sf.
DR InterPro; IPR045316; Msc2-like.
DR PANTHER; PTHR45755; PTHR45755; 1.
DR Pfam; PF01545; Cation_efflux; 1.
DR SUPFAM; SSF161111; SSF161111; 1.
DR TIGRFAMs; TIGR01297; CDF; 1.
PE 2: Evidence at transcript level;
KW Golgi apparatus; Ion transport; Membrane; Reference proteome;
KW Transmembrane; Transmembrane helix; Transport; Zinc; Zinc transport.
FT CHAIN 1..376
FT /note="Zinc transporter 7"
FT /id="PRO_0000314298"
FT TOPO_DOM 1..37
FT /note="Exoplasmic loop"
FT /evidence="ECO:0000255"
FT TRANSMEM 38..58
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 59..67
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 68..88
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 89..102
FT /note="Exoplasmic loop"
FT /evidence="ECO:0000255"
FT TRANSMEM 103..123
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 124..140
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 141..161
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 162..236
FT /note="Exoplasmic loop"
FT /evidence="ECO:0000255"
FT TRANSMEM 237..257
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 258..262
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 263..283
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 284..376
FT /note="Exoplasmic loop"
FT /evidence="ECO:0000255"
FT REGION 161..218
FT /note="His-rich loop"
FT REGION 188..226
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 188..204
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 376 AA; 41745 MW; 250E0A14EA0935AD CRC64;
MLPLSIKDDE YKPPKFNLFR KISGWFRSIL SDKTSRNLFF FLCLNLSFAF VELLYGIWSN
CLGLISDSFH MFFDSTAILA GLAASVISKW RDNDAFSYGY VRAEVLAGFV NGLFLIFTAF
FIFSEGVERA LAPPDVHHER LLLVSILGFV VNLVGIFVFK HGGHGHSHGS GHGHSHSLFN
GALDQTHGHG DHCHSHELKH GAAHSHDHAH GHGHFHSHDG PSLKETTGPS RQILQGVFLH
ILADTLGSIG VIASAIMMQN FGLMIADPIC SILIAMLIVI SVIPLLRESV GILMQRTPPL
LENTLPQCYQ RVQQLQGVYS LQEQHFWTLC SDVYVGTLKL VVAPDADARW ILSQTHNIFT
QAGVRQLYVQ IDFAAM
