ZNT7_HUMAN
ID ZNT7_HUMAN Reviewed; 376 AA.
AC Q8NEW0; B2R949; D3DT61; Q8TCH2;
DT 15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2002, sequence version 1.
DT 03-AUG-2022, entry version 172.
DE RecName: Full=Zinc transporter 7;
DE Short=ZnT-7;
DE AltName: Full=Solute carrier family 30 member 7;
DE AltName: Full=Znt-like transporter 2;
GN Name=SLC30A7; Synonyms=ZNT7, ZNTL2;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], AND SUBCELLULAR LOCATION.
RX PubMed=12446736; DOI=10.1074/jbc.m207644200;
RA Kirschke C.P., Huang L.;
RT "ZnT7, a novel mammalian zinc transporter, accumulates zinc in the Golgi
RT apparatus.";
RL J. Biol. Chem. 278:4096-4102(2003).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, AND INDUCTION.
RX PubMed=15276077; DOI=10.1016/j.bcp.2004.05.024;
RA Devergnas S., Chimienti F., Naud N., Pennequin A., Coquerel Y.,
RA Chantegrel J., Favier A., Seve M.;
RT "Differential regulation of zinc efflux transporters ZnT-1, ZnT-5 and ZnT-7
RT gene expression by zinc levels: a real-time RT-PCR study.";
RL Biochem. Pharmacol. 68:699-709(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Brain;
RA Zhu W., Mager S.;
RT "Cloning of new mammalian zinc transporter-like genes.";
RL Submitted (FEB-2000) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Trachea;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Fetal kidney;
RX PubMed=17974005; DOI=10.1186/1471-2164-8-399;
RA Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U.,
RA Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D.,
RA Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A.,
RA Wiemann S., Schupp I.;
RT "The full-ORF clone resource of the German cDNA consortium.";
RL BMC Genomics 8:399-399(2007).
RN [6]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16710414; DOI=10.1038/nature04727;
RA Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A.,
RA Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C.,
RA Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.,
RA Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C.,
RA Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W.,
RA Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J.,
RA Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J.,
RA Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y.,
RA Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J.,
RA Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H.,
RA Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L.,
RA Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J.,
RA Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S.,
RA Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K.,
RA Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R.,
RA Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M.,
RA Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S.,
RA Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J.,
RA Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W.,
RA McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N.,
RA Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V.,
RA Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J.,
RA Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E.,
RA Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S.,
RA Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M.,
RA White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H.,
RA Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E.,
RA Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G.,
RA Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.;
RT "The DNA sequence and biological annotation of human chromosome 1.";
RL Nature 441:315-321(2006).
RN [7]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN [8]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Placenta;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [9]
RP FUNCTION.
RX PubMed=15994300; DOI=10.1074/jbc.m506902200;
RA Suzuki T., Ishihara K., Migaki H., Ishihara K., Nagao M.,
RA Yamaguchi-Iwai Y., Kambe T.;
RT "Two different zinc transport complexes of cation diffusion facilitator
RT proteins localized in the secretory pathway operate to activate alkaline
RT phosphatases in vertebrate cells.";
RL J. Biol. Chem. 280:30956-30962(2005).
CC -!- FUNCTION: Seems to facilitate zinc transport from the cytoplasm into
CC the Golgi apparatus. Partly regulates cellular zinc homeostasis.
CC Required with ZNT5 for the activation of zinc-requiring enzymes,
CC alkaline phosphatases (ALPs). Transports zinc into the lumens of the
CC Golgi apparatus and the vesicular compartments where ALPs locate, thus,
CC converting apoALPs to holoALPs. Required with ZNT5 and ZNT6 for the
CC activation of TNAP (By similarity). {ECO:0000250,
CC ECO:0000269|PubMed:15276077, ECO:0000269|PubMed:15994300}.
CC -!- SUBUNIT: Homooligomer.
CC -!- SUBCELLULAR LOCATION: Golgi apparatus, trans-Golgi network membrane
CC {ECO:0000269|PubMed:12446736}; Multi-pass membrane protein
CC {ECO:0000269|PubMed:12446736}.
CC -!- INDUCTION: Increased intracellular zinc level, resulting from
CC extracellular zinc supplementation, do not induce any up- or down-
CC regulation of gene expression. Up-regulated by zinc depletion.
CC {ECO:0000269|PubMed:15276077}.
CC -!- SIMILARITY: Belongs to the cation diffusion facilitator (CDF)
CC transporter (TC 2.A.4) family. SLC30A subfamily. {ECO:0000305}.
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DR EMBL; AF529197; AAO17324.1; -; mRNA.
DR EMBL; AY094606; AAM21969.1; -; mRNA.
DR EMBL; AF233345; AAL83716.1; -; mRNA.
DR EMBL; AK313638; BAG36396.1; -; mRNA.
DR EMBL; BX537375; CAD97617.1; -; mRNA.
DR EMBL; AC104506; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AL732465; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH471097; EAW72942.1; -; Genomic_DNA.
DR EMBL; CH471097; EAW72943.1; -; Genomic_DNA.
DR EMBL; BC064692; AAH64692.1; -; mRNA.
DR CCDS; CCDS776.1; -.
DR RefSeq; NP_001138356.1; NM_001144884.1.
DR RefSeq; NP_598003.2; NM_133496.4.
DR RefSeq; XP_016855889.1; XM_017000400.1.
DR AlphaFoldDB; Q8NEW0; -.
DR SMR; Q8NEW0; -.
DR BioGRID; 127176; 108.
DR IntAct; Q8NEW0; 26.
DR MINT; Q8NEW0; -.
DR STRING; 9606.ENSP00000359130; -.
DR DrugBank; DB14533; Zinc chloride.
DR DrugBank; DB14548; Zinc sulfate, unspecified form.
DR TCDB; 2.A.4.4.5; the cation diffusion facilitator (cdf) family.
DR iPTMnet; Q8NEW0; -.
DR PhosphoSitePlus; Q8NEW0; -.
DR SwissPalm; Q8NEW0; -.
DR BioMuta; SLC30A7; -.
DR DMDM; 74751261; -.
DR EPD; Q8NEW0; -.
DR jPOST; Q8NEW0; -.
DR MassIVE; Q8NEW0; -.
DR MaxQB; Q8NEW0; -.
DR PaxDb; Q8NEW0; -.
DR PeptideAtlas; Q8NEW0; -.
DR PRIDE; Q8NEW0; -.
DR ProteomicsDB; 73224; -.
DR Antibodypedia; 20006; 81 antibodies from 18 providers.
DR DNASU; 148867; -.
DR Ensembl; ENST00000357650.9; ENSP00000350278.4; ENSG00000162695.12.
DR Ensembl; ENST00000370112.8; ENSP00000359130.4; ENSG00000162695.12.
DR GeneID; 148867; -.
DR KEGG; hsa:148867; -.
DR MANE-Select; ENST00000357650.9; ENSP00000350278.4; NM_133496.5; NP_598003.2.
DR UCSC; uc001dtn.3; human.
DR CTD; 148867; -.
DR DisGeNET; 148867; -.
DR GeneCards; SLC30A7; -.
DR HGNC; HGNC:19306; SLC30A7.
DR HPA; ENSG00000162695; Low tissue specificity.
DR MalaCards; SLC30A7; -.
DR MIM; 611149; gene.
DR neXtProt; NX_Q8NEW0; -.
DR OpenTargets; ENSG00000162695; -.
DR PharmGKB; PA134891595; -.
DR VEuPathDB; HostDB:ENSG00000162695; -.
DR eggNOG; KOG1484; Eukaryota.
DR GeneTree; ENSGT00940000159571; -.
DR HOGENOM; CLU_013430_0_3_1; -.
DR InParanoid; Q8NEW0; -.
DR OMA; WKRLIFS; -.
DR OrthoDB; 1507860at2759; -.
DR PhylomeDB; Q8NEW0; -.
DR TreeFam; TF315217; -.
DR PathwayCommons; Q8NEW0; -.
DR Reactome; R-HSA-264876; Insulin processing.
DR Reactome; R-HSA-435368; Zinc efflux and compartmentalization by the SLC30 family.
DR SignaLink; Q8NEW0; -.
DR BioGRID-ORCS; 148867; 14 hits in 1088 CRISPR screens.
DR ChiTaRS; SLC30A7; human.
DR GeneWiki; SLC30A7; -.
DR GenomeRNAi; 148867; -.
DR Pharos; Q8NEW0; Tbio.
DR PRO; PR:Q8NEW0; -.
DR Proteomes; UP000005640; Chromosome 1.
DR RNAct; Q8NEW0; protein.
DR Bgee; ENSG00000162695; Expressed in oviduct epithelium and 192 other tissues.
DR ExpressionAtlas; Q8NEW0; baseline and differential.
DR Genevisible; Q8NEW0; HS.
DR GO; GO:0005737; C:cytoplasm; IDA:BHF-UCL.
DR GO; GO:0031410; C:cytoplasmic vesicle; IBA:GO_Central.
DR GO; GO:0005794; C:Golgi apparatus; IDA:LIFEdb.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0048471; C:perinuclear region of cytoplasm; IEA:Ensembl.
DR GO; GO:0031982; C:vesicle; IDA:BHF-UCL.
DR GO; GO:0046873; F:metal ion transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0005385; F:zinc ion transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0006882; P:cellular zinc ion homeostasis; IBA:GO_Central.
DR GO; GO:0030001; P:metal ion transport; IBA:GO_Central.
DR GO; GO:0032119; P:sequestering of zinc ion; IEA:Ensembl.
DR GO; GO:1904257; P:zinc ion import into Golgi apparatus; IBA:GO_Central.
DR Gene3D; 1.20.1510.10; -; 1.
DR InterPro; IPR002524; Cation_efflux.
DR InterPro; IPR027469; Cation_efflux_TMD_sf.
DR InterPro; IPR045316; Msc2-like.
DR PANTHER; PTHR45755; PTHR45755; 1.
DR Pfam; PF01545; Cation_efflux; 1.
DR SUPFAM; SSF161111; SSF161111; 1.
DR TIGRFAMs; TIGR01297; CDF; 1.
PE 2: Evidence at transcript level;
KW Golgi apparatus; Ion transport; Membrane; Reference proteome;
KW Transmembrane; Transmembrane helix; Transport; Zinc; Zinc transport.
FT CHAIN 1..376
FT /note="Zinc transporter 7"
FT /id="PRO_0000314299"
FT TOPO_DOM 1..37
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 38..58
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 59..67
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 68..88
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 89..102
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 103..123
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 124..140
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 141..161
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 162..236
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 237..257
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 258..262
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 263..283
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 284..376
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT REGION 161..218
FT /note="His-rich loop"
FT REGION 194..226
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CONFLICT 91
FT /note="R -> G (in Ref. 3; AAL83716)"
FT /evidence="ECO:0000305"
FT CONFLICT 318
FT /note="V -> A (in Ref. 3; AAL83716)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 376 AA; 41626 MW; 8E4230C4B9EC5848 CRC64;
MLPLSIKDDE YKPPKFNLFG KISGWFRSIL SDKTSRNLFF FLCLNLSFAF VELLYGIWSN
CLGLISDSFH MFFDSTAILA GLAASVISKW RDNDAFSYGY VRAEVLAGFV NGLFLIFTAF
FIFSEGVERA LAPPDVHHER LLLVSILGFV VNLIGIFVFK HGGHGHSHGS GHGHSHSLFN
GALDQAHGHV DHCHSHEVKH GAAHSHDHAH GHGHFHSHDG PSLKETTGPS RQILQGVFLH
ILADTLGSIG VIASAIMMQN FGLMIADPIC SILIAILIVV SVIPLLRESV GILMQRTPPL
LENSLPQCYQ RVQQLQGVYS LQEQHFWTLC SDVYVGTLKL IVAPDADARW ILSQTHNIFT
QAGVRQLYVQ IDFAAM
