ZNT7_RAT
ID ZNT7_RAT Reviewed; 378 AA.
AC Q5BJM8;
DT 15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT 15-JAN-2008, sequence version 2.
DT 03-AUG-2022, entry version 107.
DE RecName: Full=Zinc transporter 7;
DE Short=ZnT-7;
DE AltName: Full=Solute carrier family 30 member 7;
GN Name=Slc30a7; Synonyms=Znt7;
OS Rattus norvegicus (Rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Rattus.
OX NCBI_TaxID=10116;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-190.
RA Takeda J., Wang H., Horikawa Y.;
RT "Expression profile of mRNAs from rat insulinoma cell line (RIN).";
RL Submitted (FEB-2006) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 165-378.
RC TISSUE=Ovary, and Spleen;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: Seems to facilitate zinc transport from the cytoplasm into
CC the Golgi apparatus. Partly regulates cellular zinc homeostasis.
CC Required with ZNT5 for the activation of zinc-requiring enzymes,
CC alkaline phosphatases (ALPs). Transports zinc into the lumens of the
CC Golgi apparatus and the vesicular compartments where ALPs locate, thus,
CC converting apoALPs to holoALPs. Required with ZNT5 and ZNT6 for the
CC activation of TNAP (By similarity). {ECO:0000250}.
CC -!- SUBUNIT: Homooligomer. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Golgi apparatus, trans-Golgi network membrane
CC {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the cation diffusion facilitator (CDF)
CC transporter (TC 2.A.4) family. SLC30A subfamily. {ECO:0000305}.
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DR EMBL; BP503381; -; NOT_ANNOTATED_CDS; mRNA.
DR EMBL; BC091417; AAH91417.1; -; mRNA.
DR EMBL; BC107441; AAI07442.1; -; mRNA.
DR RefSeq; NP_001178644.1; NM_001191715.1.
DR AlphaFoldDB; Q5BJM8; -.
DR SMR; Q5BJM8; -.
DR IntAct; Q5BJM8; 1.
DR STRING; 10116.ENSRNOP00000019172; -.
DR jPOST; Q5BJM8; -.
DR PaxDb; Q5BJM8; -.
DR PRIDE; Q5BJM8; -.
DR Ensembl; ENSRNOT00000019172; ENSRNOP00000019172; ENSRNOG00000013912.
DR GeneID; 310801; -.
DR KEGG; rno:310801; -.
DR UCSC; RGD:1307873; rat.
DR CTD; 148867; -.
DR RGD; 1307873; Slc30a7.
DR eggNOG; KOG1484; Eukaryota.
DR GeneTree; ENSGT00940000159571; -.
DR HOGENOM; CLU_013430_0_3_1; -.
DR InParanoid; Q5BJM8; -.
DR OMA; WKRLIFS; -.
DR OrthoDB; 1507860at2759; -.
DR PhylomeDB; Q5BJM8; -.
DR TreeFam; TF315217; -.
DR PRO; PR:Q5BJM8; -.
DR Proteomes; UP000002494; Chromosome 2.
DR Bgee; ENSRNOG00000013912; Expressed in jejunum and 18 other tissues.
DR Genevisible; Q5BJM8; RN.
DR GO; GO:0005737; C:cytoplasm; ISO:RGD.
DR GO; GO:0031410; C:cytoplasmic vesicle; ISO:RGD.
DR GO; GO:0005794; C:Golgi apparatus; ISO:RGD.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0048471; C:perinuclear region of cytoplasm; ISO:RGD.
DR GO; GO:0031982; C:vesicle; ISO:RGD.
DR GO; GO:0046873; F:metal ion transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0005385; F:zinc ion transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0006882; P:cellular zinc ion homeostasis; IBA:GO_Central.
DR GO; GO:0030001; P:metal ion transport; IBA:GO_Central.
DR GO; GO:0032119; P:sequestering of zinc ion; ISO:RGD.
DR GO; GO:1904257; P:zinc ion import into Golgi apparatus; IBA:GO_Central.
DR GO; GO:0006829; P:zinc ion transport; ISO:RGD.
DR Gene3D; 1.20.1510.10; -; 1.
DR InterPro; IPR002524; Cation_efflux.
DR InterPro; IPR027469; Cation_efflux_TMD_sf.
DR InterPro; IPR045316; Msc2-like.
DR PANTHER; PTHR45755; PTHR45755; 2.
DR Pfam; PF01545; Cation_efflux; 1.
DR SUPFAM; SSF161111; SSF161111; 1.
DR TIGRFAMs; TIGR01297; CDF; 1.
PE 2: Evidence at transcript level;
KW Golgi apparatus; Ion transport; Membrane; Reference proteome;
KW Transmembrane; Transmembrane helix; Transport; Zinc; Zinc transport.
FT CHAIN 1..378
FT /note="Zinc transporter 7"
FT /id="PRO_0000314301"
FT TOPO_DOM 1..37
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 38..58
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 59..67
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 68..88
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 89..102
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 103..123
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 124..140
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 141..161
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 162..238
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 239..259
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 260..264
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 265..285
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 286..378
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT REGION 161..220
FT /note="His-rich loop"
FT REGION 186..228
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 186..223
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 378 AA; 41774 MW; A82E9F3D02E2AF1A CRC64;
MLPLSIKDDE YKPPKFNLFG KISGWFRSIL SDKTSRNLFF FLCLNLSFAF VELLYGIWSN
CLGLISDSFH MFFDSTAILA GLAASVISKW RDNDAFSYGY VRAEVLAGFV NGLFLIFTAF
FIFSEGVERA LAPPDVHHER LLLVSILGFV VNLVGIFVFN HGGHGHSHGS GHGHSHSLFN
GALDHSHGHE DHCHSHGAKH GGAHSHDHDH AHGHGHLHSH DGPSFKETAG PSRQILQGVF
LHILADTLGS IGVIASAIMM QNFGLMIADP ICSILIAILI VVSVIPLLRE SIGILMQRTP
PSLENVLPQC YQRVQQLQGV YNLQEQHFWT LCSDVYVGTL KLVVAPDADA RWILSQTHNI
FTQAGVRQLY VQIDFAAM
