ZNT7_XENTR
ID ZNT7_XENTR Reviewed; 390 AA.
AC Q6P3N9;
DT 15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT 05-JUL-2004, sequence version 1.
DT 03-AUG-2022, entry version 106.
DE RecName: Full=Zinc transporter 7;
DE Short=ZnT-7;
DE AltName: Full=Solute carrier family 30 member 7;
GN Name=slc30a7; Synonyms=znt7; ORFNames=TEgg072f03.1;
OS Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX NCBI_TaxID=8364;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Egg;
RG Sanger Xenopus tropicalis EST/cDNA project;
RL Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Embryo;
RG NIH - Xenopus Gene Collection (XGC) project;
RL Submitted (DEC-2003) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Seems to facilitate zinc transport from the cytoplasm into
CC the Golgi apparatus. Partly regulates cellular zinc homeostasis (By
CC similarity). {ECO:0000250}.
CC -!- SUBUNIT: Homooligomer. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Golgi apparatus, trans-Golgi network membrane
CC {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the cation diffusion facilitator (CDF)
CC transporter (TC 2.A.4) family. SLC30A subfamily. {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; CR760496; CAJ81402.1; -; mRNA.
DR EMBL; BC063918; AAH63918.1; -; mRNA.
DR RefSeq; NP_989256.1; NM_203925.1.
DR AlphaFoldDB; Q6P3N9; -.
DR SMR; Q6P3N9; -.
DR STRING; 8364.ENSXETP00000009180; -.
DR PaxDb; Q6P3N9; -.
DR DNASU; 394867; -.
DR GeneID; 394867; -.
DR KEGG; xtr:394867; -.
DR CTD; 148867; -.
DR Xenbase; XB-GENE-977014; slc30a7.
DR eggNOG; KOG1484; Eukaryota.
DR HOGENOM; CLU_013430_0_3_1; -.
DR InParanoid; Q6P3N9; -.
DR OMA; KHEAGHE; -.
DR OrthoDB; 1507860at2759; -.
DR PhylomeDB; Q6P3N9; -.
DR TreeFam; TF315217; -.
DR Proteomes; UP000008143; Chromosome 4.
DR Proteomes; UP000790000; Unplaced.
DR Bgee; ENSXETG00000025164; Expressed in 4-cell stage embryo and 13 other tissues.
DR ExpressionAtlas; Q6P3N9; baseline.
DR GO; GO:0031410; C:cytoplasmic vesicle; IBA:GO_Central.
DR GO; GO:0005794; C:Golgi apparatus; IBA:GO_Central.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0046873; F:metal ion transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0005385; F:zinc ion transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0006882; P:cellular zinc ion homeostasis; IBA:GO_Central.
DR GO; GO:0030001; P:metal ion transport; IBA:GO_Central.
DR GO; GO:1904257; P:zinc ion import into Golgi apparatus; IBA:GO_Central.
DR Gene3D; 1.20.1510.10; -; 1.
DR InterPro; IPR002524; Cation_efflux.
DR InterPro; IPR027469; Cation_efflux_TMD_sf.
DR InterPro; IPR045316; Msc2-like.
DR PANTHER; PTHR45755; PTHR45755; 2.
DR Pfam; PF01545; Cation_efflux; 1.
DR SUPFAM; SSF161111; SSF161111; 1.
DR TIGRFAMs; TIGR01297; CDF; 1.
PE 2: Evidence at transcript level;
KW Golgi apparatus; Ion transport; Membrane; Reference proteome;
KW Transmembrane; Transmembrane helix; Transport; Zinc; Zinc transport.
FT CHAIN 1..390
FT /note="Zinc transporter 7"
FT /id="PRO_0000314306"
FT TOPO_DOM 1..37
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 38..58
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 59..67
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 68..88
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 89..102
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 103..123
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 124..140
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 141..161
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 162..250
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 251..271
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 272..276
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 277..297
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 298..390
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT REGION 161..226
FT /note="His-rich loop"
FT REGION 167..243
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 175..190
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 205..242
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 390 AA; 43064 MW; DDBA4E1FD15C2315 CRC64;
MLPLSIKDDE YKPPKFNLVR KVSGWIRSIF SDTTSRNLFC FLCLNLSFAF VELFYGIWSN
SLGLISDSFH MFFDCTALLA GLAASVISRW KTNEAFSYGY VRAEVLAGFV NGLFLIFTAF
FIFSEGIERA LDTPEVHHER LLPVSILGFL VNLIGIFVFQ HGGGHGHSHE SGHGHSHSLF
NGSLSHGHSH SHGGSHGHSH GGGHGHSHSH GEGHGHSHDQ SHKHGHGYGS SCHDEPPEEH
TGSSKQILEG VFLHIVADAL GSVGVIISTI LMQRYGLMIA DPICSMLIAL LIFVSVIPLL
KQSIGILMQR TPPSLDHVLP QCYQRVQQLQ GVYHLQEPHF WTLCTDVYIG TLKLVIGPEA
DARWILSQTH NIFTQAGVRQ LYVQIDMAAM
