ZNT9_DANRE
ID ZNT9_DANRE Reviewed; 573 AA.
AC Q5PQZ3; Q7SZY6;
DT 24-JUL-2007, integrated into UniProtKB/Swiss-Prot.
DT 04-JAN-2005, sequence version 1.
DT 03-AUG-2022, entry version 118.
DE RecName: Full=Zinc transporter 9;
DE Short=ZnT-9;
DE AltName: Full=Solute carrier family 30 member 9;
GN Name=slc30a9;
OS Danio rerio (Zebrafish) (Brachydanio rerio).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC Danionidae; Danioninae; Danio.
OX NCBI_TaxID=7955;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Tuebingen;
RX PubMed=23594743; DOI=10.1038/nature12111;
RA Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M.,
RA Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I.,
RA Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J.,
RA White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y.,
RA Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B.,
RA Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S.,
RA Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M.,
RA Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J.,
RA Clee C., Oliver K., Clark R., Riddle C., Elliot D., Threadgold G.,
RA Harden G., Ware D., Begum S., Mortimore B., Kerry G., Heath P.,
RA Phillimore B., Tracey A., Corby N., Dunn M., Johnson C., Wood J., Clark S.,
RA Pelan S., Griffiths G., Smith M., Glithero R., Howden P., Barker N.,
RA Lloyd C., Stevens C., Harley J., Holt K., Panagiotidis G., Lovell J.,
RA Beasley H., Henderson C., Gordon D., Auger K., Wright D., Collins J.,
RA Raisen C., Dyer L., Leung K., Robertson L., Ambridge K., Leongamornlert D.,
RA McGuire S., Gilderthorp R., Griffiths C., Manthravadi D., Nichol S.,
RA Barker G., Whitehead S., Kay M., Brown J., Murnane C., Gray E.,
RA Humphries M., Sycamore N., Barker D., Saunders D., Wallis J., Babbage A.,
RA Hammond S., Mashreghi-Mohammadi M., Barr L., Martin S., Wray P.,
RA Ellington A., Matthews N., Ellwood M., Woodmansey R., Clark G., Cooper J.,
RA Tromans A., Grafham D., Skuce C., Pandian R., Andrews R., Harrison E.,
RA Kimberley A., Garnett J., Fosker N., Hall R., Garner P., Kelly D., Bird C.,
RA Palmer S., Gehring I., Berger A., Dooley C.M., Ersan-Urun Z., Eser C.,
RA Geiger H., Geisler M., Karotki L., Kirn A., Konantz J., Konantz M.,
RA Oberlander M., Rudolph-Geiger S., Teucke M., Lanz C., Raddatz G.,
RA Osoegawa K., Zhu B., Rapp A., Widaa S., Langford C., Yang F.,
RA Schuster S.C., Carter N.P., Harrow J., Ning Z., Herrero J., Searle S.M.,
RA Enright A., Geisler R., Plasterk R.H., Lee C., Westerfield M.,
RA de Jong P.J., Zon L.I., Postlethwait J.H., Nusslein-Volhard C.,
RA Hubbard T.J., Roest Crollius H., Rogers J., Stemple D.L.;
RT "The zebrafish reference genome sequence and its relationship to the human
RT genome.";
RL Nature 496:498-503(2013).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RG NIH - Zebrafish Gene Collection (ZGC) project;
RL Submitted (DEC-2004) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: May act as a zinc transporter involved in intracellular zinc
CC homeostasis. May play a role as nuclear receptor coactivator.
CC {ECO:0000250|UniProtKB:Q5IRJ6, ECO:0000250|UniProtKB:Q6PML9}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000255}. Nucleus {ECO:0000250|UniProtKB:Q6PML9}.
CC Cytoplasm {ECO:0000250|UniProtKB:Q6PML9}. Cytoplasmic vesicle
CC {ECO:0000250|UniProtKB:Q6PML9}. Endoplasmic reticulum
CC {ECO:0000250|UniProtKB:Q6PML9}. Note=Mainly in the cytoplasm. Partial
CC co-localization with endoplasmic reticulum.
CC {ECO:0000250|UniProtKB:Q6PML9}.
CC -!- SIMILARITY: Belongs to the cation diffusion facilitator (CDF)
CC transporter (TC 2.A.4) family. SLC30A subfamily. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=CAE30408.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR EMBL; AL808108; CAE30408.1; ALT_SEQ; Genomic_DNA.
DR EMBL; BC086961; AAH86961.1; -; mRNA.
DR RefSeq; NP_001008575.1; NM_001008575.1.
DR RefSeq; XP_005173391.1; XM_005173334.3.
DR AlphaFoldDB; Q5PQZ3; -.
DR SMR; Q5PQZ3; -.
DR STRING; 7955.ENSDARP00000074317; -.
DR PaxDb; Q5PQZ3; -.
DR Ensembl; ENSDART00000079866; ENSDARP00000074317; ENSDARG00000057272.
DR Ensembl; ENSDART00000180361; ENSDARP00000148224; ENSDARG00000057272.
DR GeneID; 497184; -.
DR KEGG; dre:497184; -.
DR CTD; 10463; -.
DR ZFIN; ZDB-GENE-040724-254; slc30a9.
DR eggNOG; KOG2802; Eukaryota.
DR GeneTree; ENSGT00390000008346; -.
DR HOGENOM; CLU_021126_3_0_1; -.
DR InParanoid; Q5PQZ3; -.
DR OMA; IMVRAIH; -.
DR OrthoDB; 667718at2759; -.
DR PhylomeDB; Q5PQZ3; -.
DR TreeFam; TF314526; -.
DR PRO; PR:Q5PQZ3; -.
DR Proteomes; UP000000437; Genome assembly.
DR Proteomes; UP000814640; Chromosome 14.
DR Bgee; ENSDARG00000057272; Expressed in camera-type eye and 27 other tissues.
DR ExpressionAtlas; Q5PQZ3; baseline.
DR GO; GO:0031410; C:cytoplasmic vesicle; ISS:UniProtKB.
DR GO; GO:0005783; C:endoplasmic reticulum; ISS:UniProtKB.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0030374; F:nuclear receptor coactivator activity; IBA:GO_Central.
DR GO; GO:0005385; F:zinc ion transmembrane transporter activity; ISS:ZFIN.
DR GO; GO:0006882; P:cellular zinc ion homeostasis; ISS:UniProtKB.
DR GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR GO; GO:0006829; P:zinc ion transport; ISS:UniProtKB.
DR Gene3D; 1.20.1510.10; -; 1.
DR Gene3D; 3.90.530.10; -; 1.
DR InterPro; IPR002524; Cation_efflux.
DR InterPro; IPR027469; Cation_efflux_TMD_sf.
DR InterPro; IPR009061; DNA-bd_dom_put_sf.
DR InterPro; IPR040177; SLC30A9.
DR InterPro; IPR037129; XPA_sf.
DR PANTHER; PTHR13414; PTHR13414; 1.
DR Pfam; PF01545; Cation_efflux; 1.
DR SUPFAM; SSF161111; SSF161111; 1.
DR SUPFAM; SSF46955; SSF46955; 1.
DR TIGRFAMs; TIGR01297; CDF; 1.
PE 2: Evidence at transcript level;
KW Cytoplasm; Cytoplasmic vesicle; Endoplasmic reticulum; Ion transport;
KW Membrane; Nucleus; Reference proteome; Transcription;
KW Transcription regulation; Transmembrane; Transmembrane helix; Transport;
KW Zinc; Zinc transport.
FT CHAIN 1..573
FT /note="Zinc transporter 9"
FT /id="PRO_0000295808"
FT TRANSMEM 244..264
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 319..339
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 347..367
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 397..417
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 429..449
FT /note="Helical"
FT /evidence="ECO:0000255"
FT REGION 66..108
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 573 AA; 64178 MW; 5FFAC56B39D76068 CRC64;
MFPCLAHRPW QVLCRVYLQQ RAPLSQRSSK ISKPCFGWQS RGGVHKLWFS FPDFRVTSLT
WTQVQNCSTS GSGKDGSPTR PEEPKTTEKA QAAQPAAKGA GSKPQGLTKA ESIQVKVRAV
LKKREYGLKY TQNNFITAVR AMNEFCLKPS DLEHLRKIRR RSPHDDTEAF TVFLRSDVEA
KALEVWGSQE ALARERDQRK EVEREYQENI FRNQKLLKEY KDFWGNTKPR SRKRATFLQG
PGKVVMVAIC INGLNFFFKL LAWVYTGSAS MFSEAIHSLA DTCNQALLAL GISQSVRNPD
AIHPYGFSNM RYIASLISGV GIFMMGAGLS WYHGIMGLLH PQPIESLLWA YCILAGSLVS
EGATLLVAIN EIKKSARTQG LSFYEYVMQS RDPSTNVVLL EDAAAVLGVV LAAGCMGLTS
LTGNPYYDSL GSLGVGTLLG TVSAFLIYTN TEALLGRSIQ AEHMQKLTEF LENDPAVRAI
HDVKATDMGL SKVRFKAEVD FDGRVVTRSY LEKQDIEQIL NEIQQVKTPE ELENFMLKHG
ENIIDTLGAE VDRLEKELKQ RNPEVRHVDL EIL
