ID   ZNT9_PONAB              Reviewed;         569 AA.
AC   Q5R4H0; Q5RD54;
DT   24-JUL-2007, integrated into UniProtKB/Swiss-Prot.
DT   21-DEC-2004, sequence version 1.
DT   25-MAY-2022, entry version 75.
DE   RecName: Full=Zinc transporter 9;
DE            Short=ZnT-9;
DE   AltName: Full=Solute carrier family 30 member 9;
GN   Name=SLC30A9;
OS   Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Pongo.
OX   NCBI_TaxID=9601;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Brain cortex;
RG   The German cDNA consortium;
RL   Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Acts as a zinc transporter involved in intracellular zinc
CC       homeostasis. Functions as a secondary coactivator for nuclear receptors
CC       by cooperating with p160 coactivators subtypes. Plays a role in
CC       transcriptional activation of Wnt-responsive genes.
CC       {ECO:0000250|UniProtKB:Q5IRJ6, ECO:0000250|UniProtKB:Q6PML9}.
CC   -!- SUBUNIT: Interacts with GRIP1, ESR1, AR and CTNNB1.
CC       {ECO:0000250|UniProtKB:Q5IRJ6}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000255}. Nucleus {ECO:0000250|UniProtKB:Q6PML9}.
CC       Cytoplasm {ECO:0000250|UniProtKB:Q6PML9}. Cytoplasmic vesicle
CC       {ECO:0000250|UniProtKB:Q6PML9}. Endoplasmic reticulum
CC       {ECO:0000250|UniProtKB:Q6PML9}. Note=Mainly in the cytoplasm. Partial
CC       co-localization with endoplasmic reticulum.
CC       {ECO:0000250|UniProtKB:Q6PML9}.
CC   -!- SIMILARITY: Belongs to the cation diffusion facilitator (CDF)
CC       transporter (TC 2.A.4) family. SLC30A subfamily. {ECO:0000305}.
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DR   EMBL; CR858064; CAH90303.1; -; mRNA.
DR   EMBL; CR861278; CAH93346.1; -; mRNA.
DR   RefSeq; NP_001125141.1; NM_001131669.1.
DR   AlphaFoldDB; Q5R4H0; -.
DR   SMR; Q5R4H0; -.
DR   STRING; 9601.ENSPPYP00000016418; -.
DR   GeneID; 100172026; -.
DR   KEGG; pon:100172026; -.
DR   CTD; 10463; -.
DR   eggNOG; KOG2802; Eukaryota.
DR   InParanoid; Q5R4H0; -.
DR   OrthoDB; 667718at2759; -.
DR   Proteomes; UP000001595; Unplaced.
DR   GO; GO:0031410; C:cytoplasmic vesicle; ISS:UniProtKB.
DR   GO; GO:0005783; C:endoplasmic reticulum; ISS:UniProtKB.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0008324; F:cation transmembrane transporter activity; IEA:InterPro.
DR   GO; GO:0006882; P:cellular zinc ion homeostasis; ISS:UniProtKB.
DR   GO; GO:0006829; P:zinc ion transport; ISS:UniProtKB.
DR   Gene3D; 1.20.1510.10; -; 1.
DR   Gene3D; 3.90.530.10; -; 1.
DR   InterPro; IPR002524; Cation_efflux.
DR   InterPro; IPR027469; Cation_efflux_TMD_sf.
DR   InterPro; IPR009061; DNA-bd_dom_put_sf.
DR   InterPro; IPR040177; SLC30A9.
DR   InterPro; IPR037129; XPA_sf.
DR   PANTHER; PTHR13414; PTHR13414; 1.
DR   Pfam; PF01545; Cation_efflux; 1.
DR   SUPFAM; SSF161111; SSF161111; 1.
DR   SUPFAM; SSF46955; SSF46955; 1.
DR   TIGRFAMs; TIGR01297; CDF; 1.
PE   2: Evidence at transcript level;
KW   Cytoplasm; Cytoplasmic vesicle; Endoplasmic reticulum; Ion transport;
KW   Membrane; Nucleus; Reference proteome; Transcription;
KW   Transcription regulation; Transmembrane; Transmembrane helix; Transport;
KW   Zinc; Zinc transport.
FT   CHAIN           1..569
FT                   /note="Zinc transporter 9"
FT                   /id="PRO_0000295807"
FT   TRANSMEM        240..260
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        315..335
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        343..363
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        393..413
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        425..445
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   MOTIF           463..467
FT                   /note="LXXLL motif"
FT   CONFLICT        24
FT                   /note="P -> L (in Ref. 1; CAH90303)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        199
FT                   /note="E -> G (in Ref. 1; CAH90303)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        343
FT                   /note="L -> H (in Ref. 1; CAH90303)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   569 AA;  63488 MW;  E68416677A420466 CRC64;
     MLPGLAAAAA AHRCSWSSLC RLRPRCRAAA CNPSDCQEWQ NLVTFGSFSN MVPCSHPYIG
     TLSQVKLYST DVQKEGQGSQ TLRVEKVPSF ETAEGIGAEL KAPLKQEPLQ VRVKAVLKKR
     EYGSKYTQNN FITGVRAINE FCLKSSDLEQ LRKIRRRSPH EDTESFTVYL RSDVEAKSLE
     VWGSPEALAR EKKLRKEAEI EYRERLFRNQ KILREYRDFL GNTKPRSRTA SVFFKGPGKV
     VMVAICINGL NCFFKFLAWI YTGSASMFSE AIHSLSDTCN QGLLALGISK SVQTPDPSHP
     YGFSNMRYIS SLISGVGIFM MGAGLSWYHG VMGLLHPQPI ESLLWAYCIL AGSLVSEGAT
     LLVAVNELRR NARAKGMSFY KYVMESRDPS TNVILLEDTA AVLGVIIAAT CMGLTSITGN
     PLYDSLGSLG VGTLLGMVSA FLIYTNTEAL LGRSIQPEQV QRLTELLEND PSVRAIHDVK
     ATDLGLGKVR FKAEVDFDGR VVTRSYLEKQ DFDQMLQEIQ EVKTPEELET FMLKHGENII
     DTLGAEVDRL EKELKKRNPE VRHVDLEIL