ID   ZNT9_XENLA              Reviewed;         559 AA.
AC   Q6DCE3;
DT   24-JUL-2007, integrated into UniProtKB/Swiss-Prot.
DT   16-AUG-2004, sequence version 1.
DT   03-AUG-2022, entry version 82.
DE   RecName: Full=Zinc transporter 9;
DE            Short=ZnT-9;
DE   AltName: Full=Solute carrier family 30 member 9;
GN   Name=slc30a9;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Oocyte;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (JUL-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: May act as a zinc transporter involved in intracellular zinc
CC       homeostasis. May play a role as nuclear receptor coactivator.
CC       {ECO:0000250|UniProtKB:Q5IRJ6, ECO:0000250|UniProtKB:Q6PML9}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000255}. Nucleus {ECO:0000250|UniProtKB:Q6PML9}.
CC       Cytoplasm {ECO:0000250|UniProtKB:Q6PML9}. Cytoplasmic vesicle
CC       {ECO:0000250|UniProtKB:Q6PML9}. Endoplasmic reticulum
CC       {ECO:0000250|UniProtKB:Q6PML9}. Note=Mainly in the cytoplasm. Partial
CC       co-localization with endoplasmic reticulum.
CC       {ECO:0000250|UniProtKB:Q6PML9}.
CC   -!- SIMILARITY: Belongs to the cation diffusion facilitator (CDF)
CC       transporter (TC 2.A.4) family. SLC30A subfamily. {ECO:0000305}.
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DR   EMBL; BC078104; AAH78104.1; -; mRNA.
DR   RefSeq; NP_001087162.1; NM_001093693.1.
DR   AlphaFoldDB; Q6DCE3; -.
DR   SMR; Q6DCE3; -.
DR   DNASU; 447051; -.
DR   GeneID; 447051; -.
DR   KEGG; xla:447051; -.
DR   CTD; 447051; -.
DR   Xenbase; XB-GENE-976701; slc30a9.S.
DR   OMA; IMVRAIH; -.
DR   OrthoDB; 667718at2759; -.
DR   Proteomes; UP000186698; Chromosome 1S.
DR   Bgee; 447051; Expressed in egg cell and 19 other tissues.
DR   GO; GO:0031410; C:cytoplasmic vesicle; ISS:UniProtKB.
DR   GO; GO:0005783; C:endoplasmic reticulum; ISS:UniProtKB.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0008324; F:cation transmembrane transporter activity; IEA:InterPro.
DR   GO; GO:0006882; P:cellular zinc ion homeostasis; ISS:UniProtKB.
DR   GO; GO:0006829; P:zinc ion transport; ISS:UniProtKB.
DR   Gene3D; 1.20.1510.10; -; 1.
DR   Gene3D; 3.90.530.10; -; 1.
DR   InterPro; IPR002524; Cation_efflux.
DR   InterPro; IPR027469; Cation_efflux_TMD_sf.
DR   InterPro; IPR009061; DNA-bd_dom_put_sf.
DR   InterPro; IPR040177; SLC30A9.
DR   InterPro; IPR037129; XPA_sf.
DR   PANTHER; PTHR13414; PTHR13414; 1.
DR   Pfam; PF01545; Cation_efflux; 1.
DR   SUPFAM; SSF161111; SSF161111; 1.
DR   SUPFAM; SSF46955; SSF46955; 1.
DR   TIGRFAMs; TIGR01297; CDF; 1.
PE   2: Evidence at transcript level;
KW   Cytoplasm; Cytoplasmic vesicle; Endoplasmic reticulum; Ion transport;
KW   Membrane; Nucleus; Reference proteome; Transcription;
KW   Transcription regulation; Transmembrane; Transmembrane helix; Transport;
KW   Zinc; Zinc transport.
FT   CHAIN           1..559
FT                   /note="Zinc transporter 9"
FT                   /id="PRO_0000295809"
FT   TRANSMEM        230..250
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        305..325
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        333..353
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        389..409
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        415..435
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   REGION          58..96
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOTIF           453..457
FT                   /note="LXXLL motif"
FT   COMPBIAS        58..77
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   559 AA;  62202 MW;  8BFB5470E1313095 CRC64;
     MAGIYARSWP SLFRLYMRCA GTRCSGHGWQ NALESKGLLY FLPSSYLPIQ AHIRLYSSSD
     QKEDGGSKGT SAASSPEKSM AGLDPSKPEQ KSTFPPDPIQ VKVKAVLKKR EYGTKYMKNN
     FITGVRALNE FCLKPSDLES LRKIRRRSPH DDTEAFTVYL RSDVEAKAYE VWGSPEAIFR
     ERKMRKEEEI AYRENLFRNQ KLLKEYKDFL GNTKPRLSTT NMFMKGPGKV VIVAICINGL
     NFFFKLLAWV YTGSASMFSE ALHSLADTLN QALLALGISQ SARTPDPGHP YGFTNMRYIA
     SLISGVGIFM MGAGLSWYHG IIGLLHPQPI ESLLWAYCIL AGSLVSEGAT LLVAINEIRK
     SSRAKGLSFY QYVMQSRDPS TNVVLMEDAA AVLGLVMAAS CMGLTSLTGN PLYDSLGSLG
     VGTLLGAVSA FLIYTNTEAL IGRSIQPDQV QRLTELLESD PAVRAIHDVK ATDMGMSKVR
     FKAEVDFDGR VVTRSYLEKQ DIDLVLNEIR QVKTAEDLEA FMLKHGENII DTLGAEVDRL
     EKELKQRNPE VRHVDLEIL