ZNTA_DICDI
ID ZNTA_DICDI Reviewed; 507 AA.
AC Q55FL1;
DT 03-NOV-2009, integrated into UniProtKB/Swiss-Prot.
DT 18-MAR-2008, sequence version 2.
DT 25-MAY-2022, entry version 72.
DE RecName: Full=Protein zntA;
DE Flags: Precursor;
GN Name=zntA; ORFNames=DDB_0237957;
OS Dictyostelium discoideum (Slime mold).
OC Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC Dictyosteliaceae; Dictyostelium.
OX NCBI_TaxID=44689;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AX4;
RX PubMed=15875012; DOI=10.1038/nature03481;
RA Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT "The genome of the social amoeba Dictyostelium discoideum.";
RL Nature 435:43-57(2005).
RN [2]
RP DEVELOPMENTAL STAGE, AND FUNCTION.
RC STRAIN=AX2;
RX PubMed=18415938; DOI=10.1387/ijdb.072389ns;
RA Sunaga N., Monna M., Shimada N., Tsukamoto M., Kawata T.;
RT "Expression of zinc transporter family genes in Dictyostelium.";
RL Int. J. Dev. Biol. 52:377-381(2008).
CC -!- FUNCTION: May transport divalent cations (By similarity). May
CC participate, with dstA, in the regulation of the differentiation of
CC stalk cells during development. {ECO:0000250,
CC ECO:0000269|PubMed:18415938}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- DEVELOPMENTAL STAGE: Expressed in the prestalk cell type pstAB, or at
CC the stalk entrance during culmination and slug stage, this expression
CC being weak in the dstA null mutant. {ECO:0000269|PubMed:18415938}.
CC -!- SIMILARITY: Belongs to the ZIP transporter (TC 2.A.5) family.
CC {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AAFI02000003; EAL73666.2; -; Genomic_DNA.
DR RefSeq; XP_647522.2; XM_642430.2.
DR AlphaFoldDB; Q55FL1; -.
DR STRING; 44689.DDB0237957; -.
DR PaxDb; Q55FL1; -.
DR EnsemblProtists; EAL73666; EAL73666; DDB_G0268426.
DR GeneID; 8616329; -.
DR KEGG; ddi:DDB_G0268426; -.
DR dictyBase; DDB_G0268426; zplG.
DR eggNOG; ENOG502R9IA; Eukaryota.
DR HOGENOM; CLU_537971_0_0_1; -.
DR InParanoid; Q55FL1; -.
DR OMA; LISCMTP; -.
DR PRO; PR:Q55FL1; -.
DR Proteomes; UP000002195; Chromosome 1.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0016020; C:membrane; IBA:GO_Central.
DR GO; GO:0005385; F:zinc ion transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0071577; P:zinc ion transmembrane transport; IBA:GO_Central.
DR InterPro; IPR003689; ZIP.
DR Pfam; PF02535; Zip; 1.
PE 2: Evidence at transcript level;
KW Glycoprotein; Ion transport; Membrane; Reference proteome; Signal;
KW Transmembrane; Transmembrane helix; Transport.
FT SIGNAL 1..18
FT /evidence="ECO:0000255"
FT CHAIN 19..507
FT /note="Protein zntA"
FT /id="PRO_0000386634"
FT TRANSMEM 35..55
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 185..205
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 355..375
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 388..408
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 422..442
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 451..471
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 486..506
FT /note="Helical"
FT /evidence="ECO:0000255"
FT REGION 124..179
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 209..264
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 305..350
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 124..139
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 153..179
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 219..254
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 330..350
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CARBOHYD 31
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 240
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 298
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 328
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 342
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 351
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
SQ SEQUENCE 507 AA; 55173 MW; 374231BE81646107 CRC64;
MSIFAYSILA GLAPLLSSSI PFFTLRNRNI NASVFHILLC ISAGLLFAVA SLELIPESMN
LALRSFEEST KTQTSLKSTT TKTTTTTTTI GNIKLQKSFI SNSEDSLNEF HSLDNEINKP
PIEGLNLNNL NQATNLDNNE EDNDNLDNDG ENEIENDHDH DHQEDEGGDN DHDHESEEKK
EFLKIPMYGI GFGFAILIIV ESIFSSIDGG GGGGGHHSHS HGSLSSSSSN DVISDYISNN
NSNNINNNDD DNNNNNNNND DDDDSVELLE RNVVNKDNSN NINNINNNND DEDIIVINKS
IENTPNIASP VMNKDNNNND KDKNRNSNKS DIKNSGSINN GNNSGNNNNN NKSKLTITTF
IALSIHSFVD GVVISSAFSS SPHVGARVAL AIVIHKIPDG LVLSSLILSQ KKFNSGIFSN
PFFYFLLISC MTPLGSFISS FLFGGLSLSS GAFVLGFGAG TFIYITSTAI LPEILSNQIV
KKSTSLFSIF LGYLLFIFLD SQFHGAH
