ZNTB_DICDI
ID ZNTB_DICDI Reviewed; 372 AA.
AC Q54LY6;
DT 03-NOV-2009, integrated into UniProtKB/Swiss-Prot.
DT 24-MAY-2005, sequence version 1.
DT 25-MAY-2022, entry version 87.
DE RecName: Full=Protein zntB;
GN Name=zntB; ORFNames=DDB_G0286345;
OS Dictyostelium discoideum (Slime mold).
OC Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC Dictyosteliaceae; Dictyostelium.
OX NCBI_TaxID=44689;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AX4;
RX PubMed=15875012; DOI=10.1038/nature03481;
RA Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT "The genome of the social amoeba Dictyostelium discoideum.";
RL Nature 435:43-57(2005).
RN [2]
RP DEVELOPMENTAL STAGE, AND FUNCTION.
RC STRAIN=AX2;
RX PubMed=18415938; DOI=10.1387/ijdb.072389ns;
RA Sunaga N., Monna M., Shimada N., Tsukamoto M., Kawata T.;
RT "Expression of zinc transporter family genes in Dictyostelium.";
RL Int. J. Dev. Biol. 52:377-381(2008).
CC -!- FUNCTION: May transport divalent cations (By similarity). May
CC participate, with dstA, in the regulation of the differentiation of
CC stalk cells during development. {ECO:0000250,
CC ECO:0000269|PubMed:18415938}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- DEVELOPMENTAL STAGE: Expressed in the prestalk cells type pstAB, this
CC expression being absent in the dstA null mutant.
CC {ECO:0000269|PubMed:18415938}.
CC -!- SIMILARITY: Belongs to the ZIP transporter (TC 2.A.5) family. ZupT
CC subfamily. {ECO:0000305}.
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DR EMBL; AAFI02000085; EAL64348.1; -; Genomic_DNA.
DR RefSeq; XP_637845.1; XM_632753.1.
DR AlphaFoldDB; Q54LY6; -.
DR SMR; Q54LY6; -.
DR STRING; 44689.DDB0266635; -.
DR PaxDb; Q54LY6; -.
DR EnsemblProtists; EAL64348; EAL64348; DDB_G0286345.
DR GeneID; 8625559; -.
DR KEGG; ddi:DDB_G0286345; -.
DR dictyBase; DDB_G0286345; zplF.
DR eggNOG; KOG2474; Eukaryota.
DR HOGENOM; CLU_015114_3_1_1; -.
DR InParanoid; Q54LY6; -.
DR OMA; GMNGHSK; -.
DR PhylomeDB; Q54LY6; -.
DR PRO; PR:Q54LY6; -.
DR Proteomes; UP000002195; Chromosome 4.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0016020; C:membrane; IBA:GO_Central.
DR GO; GO:0005385; F:zinc ion transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0071577; P:zinc ion transmembrane transport; IBA:GO_Central.
DR InterPro; IPR003689; ZIP.
DR Pfam; PF02535; Zip; 1.
PE 2: Evidence at transcript level;
KW Coiled coil; Ion transport; Membrane; Reference proteome; Transmembrane;
KW Transmembrane helix; Transport.
FT CHAIN 1..372
FT /note="Protein zntB"
FT /id="PRO_0000386637"
FT TRANSMEM 15..35
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 42..62
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 70..90
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 170..192
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 207..229
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 237..257
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 271..291
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 301..321
FT /note="Helical"
FT /evidence="ECO:0000255"
FT REGION 99..166
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 328..372
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 133..167
FT /evidence="ECO:0000255"
FT COMPBIAS 99..124
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 358..372
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 372 AA; 40690 MW; 0A25A5EC7076A2BF CRC64;
MTSLETYNDN VKTALIMCFL SGLSTAIGGL YVIFIKQQSH KLLGHLLSFS SGVMIYISFM
DLLPESIAEI GFYNANIWFF VGIIFFAVIL RFVPHDHDES GDSNHAHSHN GASIEKHSSE
KKEVVDDDDD DNNGKDKKQK QQKQKQQKQQ QQQKQNIAKS KNKKKSKDDY LNSVGIATAI
GVSLHNFPEG VAVYLACLKG IDVGLPLMLA IAAHNIPEGM AVAAPIFSAT GSKWKAFKYC
LYSGLCEPVG AIIFGLIFKE YMTPYLIQSM LAAVAGIMVF MVIKELLPAA FKYVSVDESA
FSNIIGMIFF FFSIHFLHSM LPHDHGGAGD GGHGHSHGGH GHSHGHGHSH GGHSHDSQHV
ESPQSSSFNA FA
