ZNTB_ECOLC
ID ZNTB_ECOLC Reviewed; 327 AA.
AC B1ISR9;
DT 20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT 29-APR-2008, sequence version 1.
DT 03-AUG-2022, entry version 73.
DE RecName: Full=Zinc transport protein ZntB {ECO:0000255|HAMAP-Rule:MF_01565};
GN Name=zntB {ECO:0000255|HAMAP-Rule:MF_01565}; OrderedLocusNames=EcolC_2283;
OS Escherichia coli (strain ATCC 8739 / DSM 1576 / NBRC 3972 / NCIMB 8545 /
OS WDCM 00012 / Crooks).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC Enterobacteriaceae; Escherichia.
OX NCBI_TaxID=481805;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 8739 / DSM 1576 / NBRC 3972 / NCIMB 8545 / WDCM 00012 / Crooks;
RA Copeland A., Lucas S., Lapidus A., Glavina del Rio T., Dalin E., Tice H.,
RA Bruce D., Goodwin L., Pitluck S., Kiss H., Brettin T., Detter J.C., Han C.,
RA Kuske C.R., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N.,
RA Mikhailova N., Ingram L., Richardson P.;
RT "Complete sequence of Escherichia coli C str. ATCC 8739.";
RL Submitted (FEB-2008) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Zinc transporter. Acts as a Zn(2+):proton symporter, which
CC likely mediates zinc ion uptake. {ECO:0000255|HAMAP-Rule:MF_01565}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=H(+)(out) + Zn(2+)(out) = H(+)(in) + Zn(2+)(in);
CC Xref=Rhea:RHEA:71195, ChEBI:CHEBI:15378, ChEBI:CHEBI:29105;
CC Evidence={ECO:0000255|HAMAP-Rule:MF_01565};
CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:71196;
CC Evidence={ECO:0000255|HAMAP-Rule:MF_01565};
CC -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000255|HAMAP-
CC Rule:MF_01565}; Multi-pass membrane protein {ECO:0000255|HAMAP-
CC Rule:MF_01565}.
CC -!- SIMILARITY: Belongs to the CorA metal ion transporter (MIT) (TC 1.A.35)
CC family. {ECO:0000255|HAMAP-Rule:MF_01565}.
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DR EMBL; CP000946; ACA77919.1; -; Genomic_DNA.
DR RefSeq; WP_000387388.1; NZ_CP022959.1.
DR AlphaFoldDB; B1ISR9; -.
DR SMR; B1ISR9; -.
DR GeneID; 66674830; -.
DR KEGG; ecl:EcolC_2283; -.
DR HOGENOM; CLU_007127_2_0_6; -.
DR OMA; MVSVRIF; -.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005385; F:zinc ion transmembrane transporter activity; IEA:InterPro.
DR HAMAP; MF_01565; ZntB; 1.
DR InterPro; IPR045861; CorA_cytoplasmic_dom.
DR InterPro; IPR045863; CorA_TM1_TM2.
DR InterPro; IPR002523; MgTranspt_CorA/ZnTranspt_ZntB.
DR InterPro; IPR023714; Zn_transp_ZntB.
DR Pfam; PF01544; CorA; 1.
DR SUPFAM; SSF143865; SSF143865; 1.
DR SUPFAM; SSF144083; SSF144083; 1.
PE 3: Inferred from homology;
KW Cell inner membrane; Cell membrane; Ion transport; Membrane; Transmembrane;
KW Transmembrane helix; Transport; Zinc.
FT CHAIN 1..327
FT /note="Zinc transport protein ZntB"
FT /id="PRO_1000087821"
FT TOPO_DOM 1..273
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01565"
FT TRANSMEM 274..294
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01565"
FT TOPO_DOM 295..300
FT /note="Periplasmic"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01565"
FT TRANSMEM 301..321
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01565"
FT TOPO_DOM 322..327
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01565"
SQ SEQUENCE 327 AA; 36612 MW; B3A83F420565775D CRC64;
MEAIKGSDVN VPDAVFAWML DGRGGVKPLE NTDVIDEAHP CWLHLNYVHH DSAQWLATTP
LLPNNVRDAL AGESTRPRVS RLGEGTLITL RCINGSTDER PDQLVAMRVY MDGRLIVSTR
QRKVLALDDV VSDLEEGTGP TDCGGWLVDV CDALTDHSSE FIEQLHDKII DLEDNLLDQQ
IPPRGFLALL RKQLIVMRRY MAPQRDVYAR LASERLPWMS DDQRRRMQDI ADRLGRGLDE
IDACIARTGV MADEIAQVMQ ENLARRTYTM SLMAMVFLPS TFLTGLFGVN LGGIPGGGWQ
FGFSIFCILL VVLIGGVALW LHRSKWL