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ZNTB_SHIF8
ID   ZNTB_SHIF8              Reviewed;         327 AA.
AC   Q0T3Y9;
DT   05-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT   05-SEP-2006, sequence version 1.
DT   03-AUG-2022, entry version 76.
DE   RecName: Full=Zinc transport protein ZntB {ECO:0000255|HAMAP-Rule:MF_01565};
GN   Name=zntB {ECO:0000255|HAMAP-Rule:MF_01565}; OrderedLocusNames=SFV_1816;
OS   Shigella flexneri serotype 5b (strain 8401).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Shigella.
OX   NCBI_TaxID=373384;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=8401;
RX   PubMed=16822325; DOI=10.1186/1471-2164-7-173;
RA   Nie H., Yang F., Zhang X., Yang J., Chen L., Wang J., Xiong Z., Peng J.,
RA   Sun L., Dong J., Xue Y., Xu X., Chen S., Yao Z., Shen Y., Jin Q.;
RT   "Complete genome sequence of Shigella flexneri 5b and comparison with
RT   Shigella flexneri 2a.";
RL   BMC Genomics 7:173-173(2006).
CC   -!- FUNCTION: Zinc transporter. Acts as a Zn(2+):proton symporter, which
CC       likely mediates zinc ion uptake. {ECO:0000255|HAMAP-Rule:MF_01565}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=H(+)(out) + Zn(2+)(out) = H(+)(in) + Zn(2+)(in);
CC         Xref=Rhea:RHEA:71195, ChEBI:CHEBI:15378, ChEBI:CHEBI:29105;
CC         Evidence={ECO:0000255|HAMAP-Rule:MF_01565};
CC       PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:71196;
CC         Evidence={ECO:0000255|HAMAP-Rule:MF_01565};
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000255|HAMAP-
CC       Rule:MF_01565}; Multi-pass membrane protein {ECO:0000255|HAMAP-
CC       Rule:MF_01565}.
CC   -!- SIMILARITY: Belongs to the CorA metal ion transporter (MIT) (TC 1.A.35)
CC       family. {ECO:0000255|HAMAP-Rule:MF_01565}.
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DR   EMBL; CP000266; ABF03976.1; -; Genomic_DNA.
DR   RefSeq; WP_000387378.1; NC_008258.1.
DR   AlphaFoldDB; Q0T3Y9; -.
DR   SMR; Q0T3Y9; -.
DR   EnsemblBacteria; ABF03976; ABF03976; SFV_1816.
DR   KEGG; sfv:SFV_1816; -.
DR   HOGENOM; CLU_007127_2_0_6; -.
DR   OMA; MVSVRIF; -.
DR   BioCyc; SFLE373384:SFV_RS10135-MON; -.
DR   Proteomes; UP000000659; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005385; F:zinc ion transmembrane transporter activity; IEA:InterPro.
DR   HAMAP; MF_01565; ZntB; 1.
DR   InterPro; IPR045861; CorA_cytoplasmic_dom.
DR   InterPro; IPR045863; CorA_TM1_TM2.
DR   InterPro; IPR002523; MgTranspt_CorA/ZnTranspt_ZntB.
DR   InterPro; IPR023714; Zn_transp_ZntB.
DR   Pfam; PF01544; CorA; 1.
DR   SUPFAM; SSF143865; SSF143865; 1.
DR   SUPFAM; SSF144083; SSF144083; 1.
PE   3: Inferred from homology;
KW   Cell inner membrane; Cell membrane; Ion transport; Membrane; Transmembrane;
KW   Transmembrane helix; Transport; Zinc.
FT   CHAIN           1..327
FT                   /note="Zinc transport protein ZntB"
FT                   /id="PRO_1000069076"
FT   TOPO_DOM        1..273
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01565"
FT   TRANSMEM        274..294
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01565"
FT   TOPO_DOM        295..300
FT                   /note="Periplasmic"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01565"
FT   TRANSMEM        301..321
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01565"
FT   TOPO_DOM        322..327
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01565"
SQ   SEQUENCE   327 AA;  36672 MW;  E3ACDF42057C9186 CRC64;
     MEAIKGSDVN VPDAVFAWML DGRGGVKPLE NTDVIDEAHP CWLHLNYVHH DSAQWLATTP
     LLPNNVRDAL AGESTRPRVS RFGEGTLITL RCINGSTDER PDQLVAMRVY MDGRLIVSTR
     QRKVLALDDV VSDLEEGTGP TDCGGWLVDV CDALTDHSSE FIEQLHDKII DLEDNLLDQQ
     IPPRGFLALL RKQLIVMRRY MAPQRDVYAR LASERLPWMS DDQRRRMQDI ADRLGRGLDE
     IDACIARTGV MADEIAQVMQ ENLARRTYTM SLMAMVFLPS TFLTGLFGVN LGGIPGGGWQ
     FGFSIFCILL VVLIGGVALW LYRSKWL
 
 
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