ZNTB_YERE8
ID ZNTB_YERE8 Reviewed; 327 AA.
AC A1JNE0;
DT 05-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT 06-FEB-2007, sequence version 1.
DT 03-AUG-2022, entry version 80.
DE RecName: Full=Zinc transport protein ZntB {ECO:0000255|HAMAP-Rule:MF_01565};
GN Name=zntB {ECO:0000255|HAMAP-Rule:MF_01565}; OrderedLocusNames=YE2107;
OS Yersinia enterocolitica serotype O:8 / biotype 1B (strain NCTC 13174 /
OS 8081).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC Yersiniaceae; Yersinia.
OX NCBI_TaxID=393305;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NCTC 13174 / 8081;
RX PubMed=17173484; DOI=10.1371/journal.pgen.0020206;
RA Thomson N.R., Howard S., Wren B.W., Holden M.T.G., Crossman L.,
RA Challis G.L., Churcher C., Mungall K., Brooks K., Chillingworth T.,
RA Feltwell T., Abdellah Z., Hauser H., Jagels K., Maddison M., Moule S.,
RA Sanders M., Whitehead S., Quail M.A., Dougan G., Parkhill J.,
RA Prentice M.B.;
RT "The complete genome sequence and comparative genome analysis of the high
RT pathogenicity Yersinia enterocolitica strain 8081.";
RL PLoS Genet. 2:2039-2051(2006).
CC -!- FUNCTION: Zinc transporter. Acts as a Zn(2+):proton symporter, which
CC likely mediates zinc ion uptake. {ECO:0000255|HAMAP-Rule:MF_01565}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=H(+)(out) + Zn(2+)(out) = H(+)(in) + Zn(2+)(in);
CC Xref=Rhea:RHEA:71195, ChEBI:CHEBI:15378, ChEBI:CHEBI:29105;
CC Evidence={ECO:0000255|HAMAP-Rule:MF_01565};
CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:71196;
CC Evidence={ECO:0000255|HAMAP-Rule:MF_01565};
CC -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000255|HAMAP-
CC Rule:MF_01565}; Multi-pass membrane protein {ECO:0000255|HAMAP-
CC Rule:MF_01565}.
CC -!- SIMILARITY: Belongs to the CorA metal ion transporter (MIT) (TC 1.A.35)
CC family. {ECO:0000255|HAMAP-Rule:MF_01565}.
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DR EMBL; AM286415; CAL12179.1; -; Genomic_DNA.
DR RefSeq; WP_005169583.1; NC_008800.1.
DR RefSeq; YP_001006349.1; NC_008800.1.
DR AlphaFoldDB; A1JNE0; -.
DR SMR; A1JNE0; -.
DR STRING; 393305.YE2107; -.
DR EnsemblBacteria; CAL12179; CAL12179; YE2107.
DR GeneID; 67418250; -.
DR KEGG; yen:YE2107; -.
DR PATRIC; fig|393305.7.peg.2270; -.
DR eggNOG; COG0598; Bacteria.
DR HOGENOM; CLU_007127_2_0_6; -.
DR OMA; MVSVRIF; -.
DR Proteomes; UP000000642; Chromosome.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005385; F:zinc ion transmembrane transporter activity; IEA:InterPro.
DR HAMAP; MF_01565; ZntB; 1.
DR InterPro; IPR045861; CorA_cytoplasmic_dom.
DR InterPro; IPR045863; CorA_TM1_TM2.
DR InterPro; IPR002523; MgTranspt_CorA/ZnTranspt_ZntB.
DR InterPro; IPR023714; Zn_transp_ZntB.
DR Pfam; PF01544; CorA; 1.
DR SUPFAM; SSF143865; SSF143865; 1.
DR SUPFAM; SSF144083; SSF144083; 1.
PE 3: Inferred from homology;
KW Cell inner membrane; Cell membrane; Ion transport; Membrane; Transmembrane;
KW Transmembrane helix; Transport; Zinc.
FT CHAIN 1..327
FT /note="Zinc transport protein ZntB"
FT /id="PRO_1000069077"
FT TOPO_DOM 1..271
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01565"
FT TRANSMEM 272..292
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01565"
FT TOPO_DOM 293..300
FT /note="Periplasmic"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01565"
FT TRANSMEM 301..321
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01565"
FT TOPO_DOM 322..327
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01565"
SQ SEQUENCE 327 AA; 36541 MW; BF62152D91A9FE3E CRC64;
MDVVAGKALQ VSDAVYSYQL DGKGGVTSIS PDAVATAEQP CWLHLDYTHP DSAAWLQNTP
LLPEVVRDGL AGESVRPKVT RLGDGTMITL RGINFNNDAR PDQLVTIRVY MTDKLIVSTR
HRKVYSIDDV LNDLQSGTGP TNSGNWLVEI VDGLTDHTSE FIEDLHDKII DLEDDLLEQK
IPARGQMALL RKQLIVLRRY MAPQRDVFSR LASERLPWMN DDDRRRMQEI SERLGRGLED
LDSSIARTAV LSDEISSLMA DAMNRRTYTM SLLAMVFLPT TFLTGLFGVN LGGIPGNTDS
FGFATFCMML VVLVLGVAWW LKHSKWL