ZNTC_DICDI
ID ZNTC_DICDI Reviewed; 401 AA.
AC Q54MB9;
DT 03-NOV-2009, integrated into UniProtKB/Swiss-Prot.
DT 24-MAY-2005, sequence version 1.
DT 25-MAY-2022, entry version 81.
DE RecName: Full=Protein zntC;
GN Name=zntC; ORFNames=DDB_G0286049;
OS Dictyostelium discoideum (Slime mold).
OC Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC Dictyosteliaceae; Dictyostelium.
OX NCBI_TaxID=44689;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AX4;
RX PubMed=15875012; DOI=10.1038/nature03481;
RA Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT "The genome of the social amoeba Dictyostelium discoideum.";
RL Nature 435:43-57(2005).
RN [2]
RP DEVELOPMENTAL STAGE, AND FUNCTION.
RC STRAIN=AX2;
RX PubMed=18415938; DOI=10.1387/ijdb.072389ns;
RA Sunaga N., Monna M., Shimada N., Tsukamoto M., Kawata T.;
RT "Expression of zinc transporter family genes in Dictyostelium.";
RL Int. J. Dev. Biol. 52:377-381(2008).
CC -!- FUNCTION: May transport divalent cations (By similarity). May
CC participate, with dstA, in the regulation of the differentiation of
CC stalk cells during development. {ECO:0000250,
CC ECO:0000269|PubMed:18415938}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- DEVELOPMENTAL STAGE: Expressed in the prestalk cells type pstAB or at
CC the stalk entrance during culmination and slug stage, this expression
CC being weak in the dstA null mutant. {ECO:0000269|PubMed:18415938}.
CC -!- SIMILARITY: Belongs to the ZIP transporter (TC 2.A.5) family.
CC {ECO:0000305}.
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DR EMBL; AAFI02000085; EAL64403.1; -; Genomic_DNA.
DR RefSeq; XP_637915.1; XM_632823.1.
DR AlphaFoldDB; Q54MB9; -.
DR SMR; Q54MB9; -.
DR STRING; 44689.DDB0266634; -.
DR TCDB; 2.A.5.1.9; the zinc (zn(2+))-iron (fe(2+)) permease (zip) family.
DR PaxDb; Q54MB9; -.
DR EnsemblProtists; EAL64403; EAL64403; DDB_G0286049.
DR GeneID; 8625426; -.
DR KEGG; ddi:DDB_G0286049; -.
DR dictyBase; DDB_G0286049; zplE.
DR eggNOG; KOG1558; Eukaryota.
DR HOGENOM; CLU_673519_0_0_1; -.
DR InParanoid; Q54MB9; -.
DR OMA; EDPPILM; -.
DR PhylomeDB; Q54MB9; -.
DR Reactome; R-DDI-442380; Zinc influx into cells by the SLC39 gene family.
DR PRO; PR:Q54MB9; -.
DR Proteomes; UP000002195; Chromosome 4.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0016020; C:membrane; IBA:GO_Central.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0005385; F:zinc ion transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0071577; P:zinc ion transmembrane transport; IBA:GO_Central.
DR InterPro; IPR003689; ZIP.
DR Pfam; PF02535; Zip; 1.
PE 2: Evidence at transcript level;
KW Ion transport; Membrane; Metal-binding; Reference proteome; Transmembrane;
KW Transmembrane helix; Transport.
FT CHAIN 1..401
FT /note="Protein zntC"
FT /id="PRO_0000386635"
FT TRANSMEM 33..53
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 61..81
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 114..134
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 256..276
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 285..305
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 316..336
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 351..371
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 381..401
FT /note="Helical"
FT /evidence="ECO:0000255"
FT REGION 141..247
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 164..183
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 211..226
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 227..247
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 401 AA; 43114 MW; AD0B9F6739CD64BE CRC64;
MDIVNDLVSS ISSISSEAAE EEAIRDELRN DKGGLIAGIF VLTLTASFVP WFLTKAKITN
LVSVVSILTC LSAGVIIGAG FNHILPDAAE EFQSYVEAVA PDNKYGDFPF AHTITIVTMF
ALICVDKILV SGGLDGEADH NHMDLSQHNH PSPHAAGEID LNIYTNGDDD DDDVNEDQEE
DSTKDDEKEH GHGHGHGHGH NSSNSSSNGH GHGLKKKKKS KKEHGHGHNH DHSSNGHSHK
DEKDSEKVNV SSKSKAWVFL VALSLHSIFD GLGLGSETQK DSFYGLLIAV LAHKFLDGLV
LGIAIKYAYF SFKFSCIALV FAAAMTPLGI GIGMAISSAY ESSTDAYLVK GIILSITCGS
FIYISLIELL PSGLCQKGWP KLKLAVAFLG YSVMAILALW V
